Q8VEM8 · S25A3_MOUSE

  • Protein
    Solute carrier family 25 member 3
  • Gene
    Slc25a3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity).
Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity).
Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729).
May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Cellular Componentmyelin sheath
Molecular Functionphosphate transmembrane transporter activity
Molecular Functionphosphate:proton symporter activity
Molecular Functionprotein-containing complex binding
Biological Processmitochondrial phosphate ion transmembrane transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 25 member 3
  • Alternative names
    • Phosphate carrier protein, mitochondrial
    • Phosphate transport protein (PTP)

Gene names

    • Name
      Slc25a3

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VEM8
  • Secondary accessions
    • Q542V7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain46-58Mitochondrial intermembrane
Transmembrane59-81Helical; Name=1
Topological domain82-116Mitochondrial matrix
Transmembrane117-136Helical; Name=2
Topological domain137-156Mitochondrial intermembrane
Transmembrane157-178Helical; Name=3
Topological domain179-213Mitochondrial matrix
Transmembrane214-233Helical; Name=4
Topological domain234-256Mitochondrial intermembrane
Transmembrane257-279Helical; Name=5
Topological domain280-309Mitochondrial matrix
Transmembrane310-328Helical; Name=6
Topological domain329-357Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue, modified residue (large scale data).

Type
IDPosition(s)Source
Description
Transit peptide1-45UniProtMitochondrion
ChainPRO_000001925746-357UniProtSolute carrier family 25 member 3
Modified residue94UniProtN6-acetyllysine
Modified residue107UniProtN6-methyllysine
Modified residue (large scale data)136PTMeXchangePhosphotyrosine
Modified residue (large scale data)152PTMeXchangePhosphothreonine
Modified residue191UniProtPhosphotyrosine
Modified residue (large scale data)194PTMeXchangePhosphothreonine
Modified residue204UniProtN6-acetyllysine
Modified residue (large scale data)295PTMeXchangePhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with PPIF; the interaction is impaired by CsA.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat58-142Solcar 1
Repeat155-239Solcar 2
Repeat256-334Solcar 3

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    357
  • Mass (Da)
    39,632
  • Last updated
    2002-03-01 v1
  • MD5 Checksum
    FAC8D7A15C4E86C3CF70DEA46C107109
MFSSVAHLARANPFNAPHLQLVHDGLSGPRSPPAPPRRSRHLAAAAVEEYSCEFGSMKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSITLKEDGVRGLAKGWAPTLIGYSMQGLCKFGFYEVFKALYSNILGEENTYLWRTSLYLASSASAEFFADIALAPMEAAKVRIQTQPGYANTLREAVPKMYKEEGLNAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECTKAEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSTASQVLQRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTE

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PX16E9PX16_MOUSESlc25a3101
G5E902G5E902_MOUSESlc25a3358

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK077274
EMBL· GenBank· DDBJ
BAC36723.1
EMBL· GenBank· DDBJ
mRNA
AK077723
EMBL· GenBank· DDBJ
BAC36982.1
EMBL· GenBank· DDBJ
mRNA
AK088013
EMBL· GenBank· DDBJ
BAC40095.1
EMBL· GenBank· DDBJ
mRNA
AK150641
EMBL· GenBank· DDBJ
BAE29729.1
EMBL· GenBank· DDBJ
mRNA
AK150729
EMBL· GenBank· DDBJ
BAE29806.1
EMBL· GenBank· DDBJ
mRNA
AK150870
EMBL· GenBank· DDBJ
BAE29921.1
EMBL· GenBank· DDBJ
mRNA
AK151518
EMBL· GenBank· DDBJ
BAE30467.1
EMBL· GenBank· DDBJ
mRNA
AK152006
EMBL· GenBank· DDBJ
BAE30870.1
EMBL· GenBank· DDBJ
mRNA
AK152292
EMBL· GenBank· DDBJ
BAE31101.1
EMBL· GenBank· DDBJ
mRNA
AK152341
EMBL· GenBank· DDBJ
BAE31137.1
EMBL· GenBank· DDBJ
mRNA
AK167197
EMBL· GenBank· DDBJ
BAE39327.1
EMBL· GenBank· DDBJ
mRNA
AK168580
EMBL· GenBank· DDBJ
BAE40449.1
EMBL· GenBank· DDBJ
mRNA
BC018161
EMBL· GenBank· DDBJ
AAH18161.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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