Q8VEM8 · S25A3_MOUSE
- ProteinSolute carrier family 25 member 3
- GeneSlc25a3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids357 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity).
Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity).
Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729).
May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).
Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity).
Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729).
May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity).
Catalytic activity
- phosphate(in) + H+(in) = phosphate(out) + H+(out)This reaction proceeds in the backward direction.phosphate (in)CHEBI:43474
+ H+ (in)CHEBI:15378= phosphate (out)CHEBI:43474+ H+ (out)CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Cellular Component | myelin sheath | |
Molecular Function | phosphate transmembrane transporter activity | |
Molecular Function | phosphate:proton symporter activity | |
Molecular Function | protein-containing complex binding | |
Biological Process | mitochondrial phosphate ion transmembrane transport |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 25 member 3
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8VEM8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 46-58 | Mitochondrial intermembrane | |||
Transmembrane | 59-81 | Helical; Name=1 | |||
Topological domain | 82-116 | Mitochondrial matrix | |||
Transmembrane | 117-136 | Helical; Name=2 | |||
Topological domain | 137-156 | Mitochondrial intermembrane | |||
Transmembrane | 157-178 | Helical; Name=3 | |||
Topological domain | 179-213 | Mitochondrial matrix | |||
Transmembrane | 214-233 | Helical; Name=4 | |||
Topological domain | 234-256 | Mitochondrial intermembrane | |||
Transmembrane | 257-279 | Helical; Name=5 | |||
Topological domain | 280-309 | Mitochondrial matrix | |||
Transmembrane | 310-328 | Helical; Name=6 | |||
Topological domain | 329-357 | Mitochondrial intermembrane | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Transit peptide | 1-45 | UniProt | Mitochondrion | |||
Chain | PRO_0000019257 | 46-357 | UniProt | Solute carrier family 25 member 3 | ||
Modified residue | 94 | UniProt | N6-acetyllysine | |||
Modified residue | 107 | UniProt | N6-methyllysine | |||
Modified residue (large scale data) | 136 | PTMeXchange | Phosphotyrosine | |||
Modified residue (large scale data) | 152 | PTMeXchange | Phosphothreonine | |||
Modified residue | 191 | UniProt | Phosphotyrosine | |||
Modified residue (large scale data) | 194 | PTMeXchange | Phosphothreonine | |||
Modified residue | 204 | UniProt | N6-acetyllysine | |||
Modified residue (large scale data) | 295 | PTMeXchange | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 58-142 | Solcar 1 | |||
Repeat | 155-239 | Solcar 2 | |||
Repeat | 256-334 | Solcar 3 | |||
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length357
- Mass (Da)39,632
- Last updated2002-03-01 v1
- MD5 ChecksumFAC8D7A15C4E86C3CF70DEA46C107109
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK077274 EMBL· GenBank· DDBJ | BAC36723.1 EMBL· GenBank· DDBJ | mRNA | ||
AK077723 EMBL· GenBank· DDBJ | BAC36982.1 EMBL· GenBank· DDBJ | mRNA | ||
AK088013 EMBL· GenBank· DDBJ | BAC40095.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150641 EMBL· GenBank· DDBJ | BAE29729.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150729 EMBL· GenBank· DDBJ | BAE29806.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150870 EMBL· GenBank· DDBJ | BAE29921.1 EMBL· GenBank· DDBJ | mRNA | ||
AK151518 EMBL· GenBank· DDBJ | BAE30467.1 EMBL· GenBank· DDBJ | mRNA | ||
AK152006 EMBL· GenBank· DDBJ | BAE30870.1 EMBL· GenBank· DDBJ | mRNA | ||
AK152292 EMBL· GenBank· DDBJ | BAE31101.1 EMBL· GenBank· DDBJ | mRNA | ||
AK152341 EMBL· GenBank· DDBJ | BAE31137.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167197 EMBL· GenBank· DDBJ | BAE39327.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168580 EMBL· GenBank· DDBJ | BAE40449.1 EMBL· GenBank· DDBJ | mRNA | ||
BC018161 EMBL· GenBank· DDBJ | AAH18161.1 EMBL· GenBank· DDBJ | mRNA |