Q8VCP8 · KAD6_MOUSE
- ProteinAdenylate kinase isoenzyme 6
- GeneAk6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids172 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation.
Catalytic activity
- AMP + ATP = 2 ADP
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 16 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 17 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 109 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Cajal body | |
Cellular Component | cytoplasm | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase isoenzyme 6
- EC number
- Short namesAK6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8VCP8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000153897 | 1-172 | Adenylate kinase isoenzyme 6 | |||
Sequence: MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGQLYDGYDEEYGCPILDEDRVVDELEHQMQEGGVIVDYHGCDFFPERWFHIVFVLRTDNGVLYKRLETRGYNEKKLQDNIQCEIFQVLYEEAIASYKEEIVHQLPSNEPEQLEDNINQISKWIEQWVKDHNP |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11. Interacts with COIL (via C-terminus).
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 33-56 | NMPbind | ||||
Sequence: NVGDLAREGQLYDGYDEEYGCPIL | ||||||
Region | 108-118 | LID | ||||
Sequence: TRGYNEKKLQD |
Sequence similarities
Belongs to the adenylate kinase family. AK6 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length172
- Mass (Da)19,947
- Last updated2002-03-01 v1
- Checksum55F56E3420103514
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WRI5 | A0A087WRI5_MOUSE | Ak6 | 41 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC019453 EMBL· GenBank· DDBJ | AAH19453.1 EMBL· GenBank· DDBJ | mRNA |