Q8VCP8 · KAD6_MOUSE

  • Protein
    Adenylate kinase isoenzyme 6
  • Gene
    Ak6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation.

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13ATP (UniProtKB | ChEBI)
Binding site15ATP (UniProtKB | ChEBI)
Binding site16ATP (UniProtKB | ChEBI)
Binding site17ATP (UniProtKB | ChEBI)
Binding site18ATP (UniProtKB | ChEBI)
Binding site109ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentCajal body
Cellular Componentcytoplasm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6
  • EC number
  • Short names
    AK6
  • Alternative names
    • Coilin-interacting nuclear ATPase protein
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • Name
      Ak6
    • Synonyms
      Cinap

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VCP8

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus, nucleoplasm
Nucleus, Cajal body
Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001538971-172Adenylate kinase isoenzyme 6

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11. Interacts with COIL (via C-terminus).

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region33-56NMPbind
Region108-118LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    172
  • Mass (Da)
    19,947
  • Last updated
    2002-03-01 v1
  • Checksum
    55F56E3420103514
MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGQLYDGYDEEYGCPILDEDRVVDELEHQMQEGGVIVDYHGCDFFPERWFHIVFVLRTDNGVLYKRLETRGYNEKKLQDNIQCEIFQVLYEEAIASYKEEIVHQLPSNEPEQLEDNINQISKWIEQWVKDHNP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087WRI5A0A087WRI5_MOUSEAk641

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC019453
EMBL· GenBank· DDBJ
AAH19453.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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