Q8VCH2 · CLM5_MOUSE

  • Protein
    CMRF35-like molecule 5
  • Gene
    Cd300ld
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as an activating receptor in myeloid cells and mast cells.
(Microbial infection) Acts as a functional murine norovirus (MNV) receptor. Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27540007, PubMed:27681626).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionvirus receptor activity
Biological Processimmune system process
Biological Processregulation of interleukin-6 production
Biological Processregulation of tumor necrosis factor production

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    CMRF35-like molecule 5
  • Short names
    CLM-5
  • Alternative names
    • CD300 antigen like family member D
    • Leukocyte mono-Ig-like receptor 4
    • Myeloid-associated immunoglobulin-like receptor 4 (MAIR-4; MAIR-IV)

Gene names

    • Name
      Cd300ld
    • Synonyms
      Clm5
      , Lmir4

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • CBA/J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VCH2
  • Secondary accessions
    • Q8BRU3

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain19-177Extracellular
Transmembrane178-198Helical
Topological domain199-221Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis165-170Decreases surface expression in transfected pro-B cells and impairs interaction with FCER1G.
Mutagenesis177-186Increases surface expression in transfected pro-B cells and impairs interaction with FCER1G.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000032012819-221CMRF35-like molecule 5
Disulfide bond40↔108

Post-translational modification

O-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in dendritic cells, macrophages and granulocytes. Present on the surface of granulocytes and monocytes/macrophages (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with FCER1G.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain19-124Ig-like V-type
Region38-48May play an important role in murine norovirus (MNV) binding
Region165-170Important for maintaining surface expression and for interaction with FCER1G
Region177-186Important for maintaining surface expression and for interaction with FCER1G

Sequence similarities

Belongs to the CD300 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    221
  • Mass (Da)
    24,954
  • Last updated
    2002-03-01 v1
  • Checksum
    C9E6203BE64922C1
MWQFSALLLFFLPGCCTAQDSVTGPEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPQRSCDILVETDKSEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSDAGIYWCGITKGGPDPMFKVNVNIDQAPKSSMMTTTATVLKSIQPSAENTGKEQVTQSKEVTQSRPHTRSLLSSIYFLLMVFVELPLLLSMLSAVLWVTRPQRCFGRGENDLVKTHSPVA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict20-21in Ref. 2; AB292062
Sequence conflict41-48in Ref. 2; AB292062
Sequence conflict55in Ref. 2; AB292062
Sequence conflict60in Ref. 2; AB292062
Sequence conflict63-66in Ref. 2; AB292062
Sequence conflict88in Ref. 2; AB292062
Sequence conflict94in Ref. 2; AB292062
Sequence conflict113-118in Ref. 2; AB292062
Sequence conflict124-127in Ref. 2; AB292062
Sequence conflict188in Ref. 3; BAC30893

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY457051
EMBL· GenBank· DDBJ
AAR27942.1
EMBL· GenBank· DDBJ
mRNA
AB292062
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK041292
EMBL· GenBank· DDBJ
BAC30893.1
EMBL· GenBank· DDBJ
mRNA
BC019814
EMBL· GenBank· DDBJ
AAH19814.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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