Q8VCA5 · TMPS4_MOUSE

  • Protein
    Transmembrane protease serine 4
  • Gene
    Tmprss4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (By similarity).
Seems to be capable of activating ENaC (PubMed:12149280).

Features

Showing features for site, active site.

143550100150200250300350400
Type
IDPosition(s)Description
Site202-203Cleavage
Active site243Charge relay system
Active site288Charge relay system
Active site385Charge relay system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Cellular Componentsecretory granule
Molecular Functionserine-type endopeptidase activity
Molecular Functionserine-type peptidase activity
Biological Processnegative regulation of growth rate
Biological Processpositive regulation of viral entry into host cell
Biological Processprotein processing
Biological Processproteolysis
Biological Processregulation of gene expression
Biological Processresponse to wounding

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Tmprss4
    • Synonyms
      Cap2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VCA5

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein

Transmembrane protease serine 4 catalytic chain

Secreted
Note: Activated by cleavage and secreted.

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-30Cytoplasmic
Transmembrane31-51Helical; Signal-anchor for type II membrane protein
Topological domain52-435Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
ChainPRO_0000451628?-435Transmembrane protease serine 4 catalytic chain
ChainPRO_00000886931-435Transmembrane protease serine 4
Disulfide bond62↔81
Disulfide bond75↔90
Disulfide bond125↔181
Glycosylation128N-linked (GlcNAc...) asparagine
Disulfide bond138↔191
Glycosylation176N-linked (GlcNAc...) asparagine
Disulfide bond194↔308
Disulfide bond228↔244
Disulfide bond354↔370
Disulfide bond381↔408

Post-translational modification

Proteolytically processed; probably by an autocatalytic mechanism.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain59-101LDL-receptor class A
Domain102-202SRCR
Domain203-432Peptidase S1

Sequence similarities

Belongs to the peptidase S1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    435
  • Mass (Da)
    47,496
  • Last updated
    2002-03-01 v1
  • Checksum
    DC52E45A43E01369
MESDSGQPLNNRDIVPFRKPRRPQETFKKVGIPIIAVLLSLIALVIVALLIKVILDKYYFICGSPLTFIQRGQLCDGHLDCASGEDEEHCVKDFPEKPGVAVRLSKDRSTLQVLDAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q4A7E9Q4A7_MOUSETmprss440
E9Q4T9E9Q4T9_MOUSETmprss4335

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY043240
EMBL· GenBank· DDBJ
AAK85307.1
EMBL· GenBank· DDBJ
mRNA
BC021368
EMBL· GenBank· DDBJ
AAH21368.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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