Q8VBW5 · BBX_MOUSE

  • Protein
    HMG box transcription factor BBX
  • Gene
    Bbx
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Transcription factor that is necessary for cell cycle progression from G1 to S phase.

Features

Showing features for dna binding.

1907100200300400500600700800900
TypeIDPosition(s)Description
DNA binding80-148HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processbone development
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    HMG box transcription factor BBX
  • Alternative names
    • Bobby sox homolog
    • HMG box-containing protein 2

Gene names

    • Name
      Bbx
    • Synonyms
      Hbp2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • C3H/He
    • NMRI
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VBW5
  • Secondary accessions
    • B8JK46
    • B8JK47
    • B8JK48
    • B8JK49
    • Q3TZK1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant30in strain: C3H/He
Natural variant281in strain: C3H/He

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 50 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue, cross-link.

TypeIDPosition(s)Description
ChainPRO_00002328861-907HMG box transcription factor BBX
Modified residue242Phosphoserine
Cross-link384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue476Phosphoserine
Modified residue483Phosphoserine
Cross-link571Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link693Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue701Phosphoserine
Modified residue789Phosphoserine
Modified residue811Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-24Disordered
Region37-80Disordered
Compositional bias40-55Acidic residues
Region152-185Disordered
Region220-242Disordered
Region435-483Disordered
Compositional bias459-479Basic and acidic residues
Region495-612Disordered
Compositional bias592-612Basic and acidic residues
Region628-672Disordered
Compositional bias646-668Polar residues
Region708-736Disordered
Region769-854Disordered
Compositional bias773-787Polar residues
Region877-907Disordered

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q8VBW5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    BbxA
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    907
  • Mass (Da)
    100,783
  • Last updated
    2006-04-18 v2
  • Checksum
    53E113D4B3DE4DAC
MKGSNRNKDHSTEGEGDGKRPKRKCLQWHPLLAKKLLDFSEEEEEDEEEEDIDKVQLLEADGLEQDVAETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYRWCPTTNKPVKSPTPTVNPRKKLWAFPPDSSRDLPTPKKAKTEVPQLNFGMADPTQMGGLSMLLLAGEHALGTPEASSGTCRPDISESPELRQKSPLFQFAEISSRTSHPDAPSKQCQASALFQFAEISSSTSQLGGTEPVKRCGNSALFQLAEMCLASEGVKMEDTKLIKSKESDGGRIEEIEKGKEERGTEVEKTTETSFQKEAEFGKSAKGNVRESKDLRDIEQLQMDNVMAIKVEDPKEIRKEPEDDQKYSHFPDFSYSASSKIIISGVPSRKDHMCHPHGIMIIEDPTTLNKPEKIKKKKKKNKLDRHGNDKSTPKKTCKKRQSSESDIESVMYTIEAVAKGDWGVDKLGETPRKKVRPSSSGKGGILDAKPPKKKVKSKEKKVSKEKCSDITKESRPPDFLSISASKSVPGEVPEGIKAEPLTPTEDALPPSLPGQAKPEDSDCHRKTETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWSEESWTFNQSGTSGSKKFKKKLREDSFLGSAKLDEEFEKKFNSLPQYSPITFDRKCVSTPRKKKKTGNMSSESTKTSKGSGDKWSHKQFFLDAIHPTEAIFSEDKSTTEPAFKVKNALSIPNTPEPTTMQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKVPGTYCGDNCSHSTVEEPRSSTPDMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ

Q8VBW5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8VBW5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8VBW5-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 733-750: SGDKWSHKQFFLDAIHPT → PFQSQKKNLFHKIVSKYK
    • 751-907: Missing

Sequence caution

The sequence AAL68987.1 differs from that shown. Reason: Miscellaneous discrepancy Contaminating sequence. Potential poly-A sequence.
The sequence AAL68988.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias40-55Acidic residues
Alternative sequenceVSP_01800755-135in isoform 2
Alternative sequenceVSP_018008223-249in isoform 2
Sequence conflict269in Ref. 1; AAL58872/AAL58873 and 2; BAB30768
Sequence conflict450in Ref. 2; BAC34285
Sequence conflict455in Ref. 1; AAL58872/AAL58873
Compositional bias459-479Basic and acidic residues
Compositional bias592-612Basic and acidic residues
Compositional bias646-668Polar residues
Alternative sequenceVSP_018009730in isoform 2
Alternative sequenceVSP_018010732-751in isoform 3
Alternative sequenceVSP_018011733-750in isoform 4
Alternative sequenceVSP_018012751-907in isoform 4
Compositional bias773-787Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF454943
EMBL· GenBank· DDBJ
AAL58872.1
EMBL· GenBank· DDBJ
mRNA
AF454944
EMBL· GenBank· DDBJ
AAL58873.1
EMBL· GenBank· DDBJ
mRNA
AK017487
EMBL· GenBank· DDBJ
BAB30768.1
EMBL· GenBank· DDBJ
mRNA
AK029532
EMBL· GenBank· DDBJ
BAC26500.2
EMBL· GenBank· DDBJ
mRNA
AK029747
EMBL· GenBank· DDBJ
BAC26596.1
EMBL· GenBank· DDBJ
mRNA
AK049516
EMBL· GenBank· DDBJ
BAC33788.1
EMBL· GenBank· DDBJ
mRNA
AK050488
EMBL· GenBank· DDBJ
BAC34285.1
EMBL· GenBank· DDBJ
mRNA
AK157813
EMBL· GenBank· DDBJ
BAE34207.1
EMBL· GenBank· DDBJ
mRNA
AC109627
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT571273
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC057869
EMBL· GenBank· DDBJ
AAH57869.1
EMBL· GenBank· DDBJ
mRNA
BC066821
EMBL· GenBank· DDBJ
AAH66821.1
EMBL· GenBank· DDBJ
mRNA
AF276950
EMBL· GenBank· DDBJ
AAL68986.1
EMBL· GenBank· DDBJ
mRNA
AF276951
EMBL· GenBank· DDBJ
AAL68987.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AF276952
EMBL· GenBank· DDBJ
AAL68988.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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