Q8VBV9 · O51E2_MOUSE
- ProteinOlfactory receptor 51E2
- GeneOr51e2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids320 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Olfactory receptor. The activity of this receptor is probably mediated by G-proteins wich induce elevation of intracellular Ca2+, cAMP and activation of phosphorylation of the protein kinases PKA and MAPK3/MAPK1. Activation of OR51E2 may affect melanocyte proliferation, differentiation, and melanogenesis and may increase proliferation and migration of primary retinal pigment epithelial (RPE) cells (By similarity).
Activated by the short chain fatty acids (SCFA), acetate and propionate (PubMed:23401498).
In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498).
May also be activated by steroid hormones and regulate cell proliferation (By similarity).
Activated by L-lactate in glomus cells (PubMed:26560302, PubMed:30258151).
Activated by the short chain fatty acids (SCFA), acetate and propionate (PubMed:23401498).
In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498).
May also be activated by steroid hormones and regulate cell proliferation (By similarity).
Activated by L-lactate in glomus cells (PubMed:26560302, PubMed:30258151).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | nuclear steroid receptor activity | |
Molecular Function | olfactory receptor activity | |
Molecular Function | signaling receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | cell migration | |
Biological Process | cellular response to fatty acid | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | melanocyte differentiation | |
Biological Process | melanocyte proliferation | |
Biological Process | positive regulation of blood pressure | |
Biological Process | positive regulation of renin secretion into blood stream | |
Biological Process | sensory perception of smell | |
Biological Process | steroid hormone receptor signaling pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOlfactory receptor 51E2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8VBV9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Early endosome membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-27 | Extracellular | ||||
Sequence: MSSCNFTHATFLLIGIPGLEEAHFWFG | ||||||
Transmembrane | 28-48 | Helical; Name=1 | ||||
Sequence: FPLLSMYAVALFGNCIVVFIV | ||||||
Topological domain | 49-53 | Cytoplasmic | ||||
Sequence: RTERS | ||||||
Transmembrane | 54-74 | Helical; Name=2 | ||||
Sequence: LHAPMYLFLCMLAAIDLALST | ||||||
Topological domain | 75-98 | Extracellular | ||||
Sequence: STMPKILALFWFDSREITFDACLA | ||||||
Transmembrane | 99-119 | Helical; Name=3 | ||||
Sequence: QMFFIHTLSAIESTILLAMAF | ||||||
Topological domain | 120-141 | Cytoplasmic | ||||
Sequence: DRYVAICHPLRHAAVLNNTVTV | ||||||
Transmembrane | 142-162 | Helical; Name=4 | ||||
Sequence: QIGMVALVRGSLFFFPLPLLI | ||||||
Topological domain | 163-200 | Extracellular | ||||
Sequence: KRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLT | ||||||
Transmembrane | 201-221 | Helical; Name=5 | ||||
Sequence: AILLVMGVDVMFISLSYFLII | ||||||
Topological domain | 222-239 | Cytoplasmic | ||||
Sequence: RTVLQLPSKSERAKAFGT | ||||||
Transmembrane | 240-260 | Helical; Name=6 | ||||
Sequence: CVSHISVVLAFYVPLIGLSVV | ||||||
Topological domain | 261-269 | Extracellular | ||||
Sequence: HRFGNSLDP | ||||||
Transmembrane | 270-290 | Helical; Name=7 | ||||
Sequence: IVHVLMGDVYLLLPPVINPII | ||||||
Topological domain | 291-320 | Cytoplasmic | ||||
Sequence: YGAKTKQIRTRVLAMFKISCDKDIEAGGNT |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Knockout mice display reduced baseline blood pressure.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000430209 | 1-320 | Olfactory receptor 51E2 | |||
Sequence: MSSCNFTHATFLLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFFIHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHISVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMGDVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 96↔178 | |||||
Sequence: CLAQMFFIHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
In brain, expressed in medulla oblongata by cells close to the fourth ventricle, in the area postrema, the nucleus tractus solitarius (PubMed:11707321).
Expressed in olfactory epithelium and vomeronasal organ (PubMed:11069588).
Expressed in kidney by large renal vessels, renal afferent arterioles, and extrarenal vascular beds. In small resistance vessels the expression is restricted to cells of the juxtaglomerular afferent arteriole, which mediate renin secretion. Also detected in small blood vessels in a variety of tissues including heart, diaphragm, skeletal muscle, and skin. In the heart, esophagus, and stomach it is detected in axons of autonomic neurons and neurons of the enteric plexus (PubMed:23401498).
Also detected in colon and liver (PubMed:23401498).
Expressed in the glomus cells of the carotid body (PubMed:26560302).
Expressed in olfactory epithelium and vomeronasal organ (PubMed:11069588).
Expressed in kidney by large renal vessels, renal afferent arterioles, and extrarenal vascular beds. In small resistance vessels the expression is restricted to cells of the juxtaglomerular afferent arteriole, which mediate renin secretion. Also detected in small blood vessels in a variety of tissues including heart, diaphragm, skeletal muscle, and skin. In the heart, esophagus, and stomach it is detected in axons of autonomic neurons and neurons of the enteric plexus (PubMed:23401498).
Also detected in colon and liver (PubMed:23401498).
Expressed in the glomus cells of the carotid body (PubMed:26560302).
Developmental stage
Primarily detected between 11 dpc and 12 dpc. Expressed at 12 dpc in the dorsal region of the developing nasal cavity and in the mesenchyme located between the olfactory epithelium and the presumptive olfactory bulb. In the medulla oblongata, first detected at 17 dpc. In the area postrema and the nucleus tractus solitarius expression peaks at P20 and then decreases slightly.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length320
- Mass (Da)35,578
- Last updated2002-03-01 v1
- Checksum7161ACA8F4328959
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF378854 EMBL· GenBank· DDBJ | AAL35109.1 EMBL· GenBank· DDBJ | mRNA | ||
AY073011 EMBL· GenBank· DDBJ | AAL60674.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY317674 EMBL· GenBank· DDBJ | AAP71053.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK028467 EMBL· GenBank· DDBJ | BAC25966.1 EMBL· GenBank· DDBJ | mRNA | ||
AK036356 EMBL· GenBank· DDBJ | BAC29396.1 EMBL· GenBank· DDBJ | mRNA | ||
AC162175 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466531 EMBL· GenBank· DDBJ | EDL16625.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH466531 EMBL· GenBank· DDBJ | EDL16627.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC120603 EMBL· GenBank· DDBJ | AAI20604.1 EMBL· GenBank· DDBJ | mRNA | ||
BC120629 EMBL· GenBank· DDBJ | AAI20630.1 EMBL· GenBank· DDBJ | mRNA |