Q8VBS7 · V1R42_MOUSE
- ProteinVomeronasal type-1 receptor 42
- GeneVmn1r42
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids329 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | pheromone receptor activity | |
Biological Process | response to pheromone | |
Biological Process | sensory perception of chemical stimulus |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameVomeronasal type-1 receptor 42
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8VBS7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-32 | Extracellular | ||||
Sequence: MGDILFSSPQSMFSHTMNKNSILHTHSIIGKT | ||||||
Transmembrane | 33-53 | Helical; Name=1 | ||||
Sequence: FFSEIGIGISGNSFLLLVHIL | ||||||
Topological domain | 54-65 | Cytoplasmic | ||||
Sequence: KFIRGHRPRLTD | ||||||
Transmembrane | 66-86 | Helical; Name=2 | ||||
Sequence: LPIGLLSLIHLLMLLVAAFIA | ||||||
Topological domain | 87-109 | Extracellular | ||||
Sequence: TDIFISRRGWDDIICKFLVYLYR | ||||||
Transmembrane | 110-130 | Helical; Name=3 | ||||
Sequence: VLRGFSLCTTSMLSILQAIIL | ||||||
Topological domain | 131-150 | Cytoplasmic | ||||
Sequence: SPRSSCLAKFKHISPHHISG | ||||||
Transmembrane | 151-171 | Helical; Name=4 | ||||
Sequence: AILFLSVLYMLIGSQLLVSII | ||||||
Topological domain | 172-209 | Extracellular | ||||
Sequence: ATPNLTMNDFIYVTQSCSILPLSYLMQSIYSTLLAIRE | ||||||
Transmembrane | 210-230 | Helical; Name=5 | ||||
Sequence: FFLISLMVLSNWYMVALLSMH | ||||||
Topological domain | 231-254 | Cytoplasmic | ||||
Sequence: RKQTQHLHGTNLSPKKSPEQSATQ | ||||||
Transmembrane | 255-275 | Helical; Name=6 | ||||
Sequence: TILMLISFFLLMTIYDTIVSC | ||||||
Topological domain | 276-285 | Extracellular | ||||
Sequence: SRTMFLNDPT | ||||||
Transmembrane | 286-306 | Helical; Name=7 | ||||
Sequence: SYSIELFIMHIYATVSPFVFM | ||||||
Topological domain | 307-329 | Cytoplasmic | ||||
Sequence: STEKHIVNFLRSLGKRVINFNLH |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 39 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000239961 | 1-329 | Vomeronasal type-1 receptor 42 | |||
Sequence: MGDILFSSPQSMFSHTMNKNSILHTHSIIGKTFFSEIGIGISGNSFLLLVHILKFIRGHRPRLTDLPIGLLSLIHLLMLLVAAFIATDIFISRRGWDDIICKFLVYLYRVLRGFSLCTTSMLSILQAIILSPRSSCLAKFKHISPHHISGAILFLSVLYMLIGSQLLVSIIATPNLTMNDFIYVTQSCSILPLSYLMQSIYSTLLAIREFFLISLMVLSNWYMVALLSMHRKQTQHLHGTNLSPKKSPEQSATQTILMLISFFLLMTIYDTIVSCSRTMFLNDPTSYSIELFIMHIYATVSPFVFMSTEKHIVNFLRSLGKRVINFNLH | ||||||
Disulfide bond | 101↔188 | |||||
Sequence: CKFLVYLYRVLRGFSLCTTSMLSILQAIILSPRSSCLAKFKHISPHHISGAILFLSVLYMLIGSQLLVSIIATPNLTMNDFIYVTQSC | ||||||
Glycosylation | 175 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length329
- Mass (Da)37,352
- Last updated2002-03-01 v1
- ChecksumFF172A215088CC79
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB062891 EMBL· GenBank· DDBJ | BAB79209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB062892 EMBL· GenBank· DDBJ | BAB79210.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY044662 EMBL· GenBank· DDBJ | AAK98772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF291485 EMBL· GenBank· DDBJ | AAG42079.1 EMBL· GenBank· DDBJ | Genomic DNA |