Q8VBS7 · V1R42_MOUSE

  • Protein
    Vomeronasal type-1 receptor 42
  • Gene
    Vmn1r42
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Putative pheromone receptor implicated in the regulation of social and reproductive behavior.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionpheromone receptor activity
Biological Processresponse to pheromone
Biological Processsensory perception of chemical stimulus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vomeronasal type-1 receptor 42
  • Alternative names
    • Vomeronasal type-1 receptor A1
    • Vomeronasal type-1 receptor A10
    • Vomeronasal type-1 receptor A3
    • Vomeronasal type-1 receptor A6

Gene names

    • Name
      Vmn1r42
    • Synonyms
      V1ra1
      , V1ra10, V1ra3
      , V1ra6

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • 129/SvJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8VBS7
  • Secondary accessions
    • Q9EQ49

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-32Extracellular
Transmembrane33-53Helical; Name=1
Topological domain54-65Cytoplasmic
Transmembrane66-86Helical; Name=2
Topological domain87-109Extracellular
Transmembrane110-130Helical; Name=3
Topological domain131-150Cytoplasmic
Transmembrane151-171Helical; Name=4
Topological domain172-209Extracellular
Transmembrane210-230Helical; Name=5
Topological domain231-254Cytoplasmic
Transmembrane255-275Helical; Name=6
Topological domain276-285Extracellular
Transmembrane286-306Helical; Name=7
Topological domain307-329Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 39 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002399611-329Vomeronasal type-1 receptor 42
Disulfide bond101↔188
Glycosylation175N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    37,352
  • Last updated
    2002-03-01 v1
  • Checksum
    FF172A215088CC79
MGDILFSSPQSMFSHTMNKNSILHTHSIIGKTFFSEIGIGISGNSFLLLVHILKFIRGHRPRLTDLPIGLLSLIHLLMLLVAAFIATDIFISRRGWDDIICKFLVYLYRVLRGFSLCTTSMLSILQAIILSPRSSCLAKFKHISPHHISGAILFLSVLYMLIGSQLLVSIIATPNLTMNDFIYVTQSCSILPLSYLMQSIYSTLLAIREFFLISLMVLSNWYMVALLSMHRKQTQHLHGTNLSPKKSPEQSATQTILMLISFFLLMTIYDTIVSCSRTMFLNDPTSYSIELFIMHIYATVSPFVFMSTEKHIVNFLRSLGKRVINFNLH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB062891
EMBL· GenBank· DDBJ
BAB79209.1
EMBL· GenBank· DDBJ
Genomic DNA
AB062892
EMBL· GenBank· DDBJ
BAB79210.1
EMBL· GenBank· DDBJ
Genomic DNA
AY044662
EMBL· GenBank· DDBJ
AAK98772.1
EMBL· GenBank· DDBJ
Genomic DNA
AF291485
EMBL· GenBank· DDBJ
AAG42079.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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