Q8UUZ1 · MB212_DANRE

Function

function

Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Biological Processcamera-type eye development
Biological Processclosure of optic fissure
Biological Processcornea development in camera-type eye
Biological Processembryonic cranial skeleton morphogenesis
Biological Processembryonic eye morphogenesis
Biological Processenteric nervous system development
Biological Processeye development
Biological Processlens development in camera-type eye
Biological Processlens morphogenesis in camera-type eye
Biological Processoptic cup morphogenesis involved in camera-type eye development
Biological Processretina development in camera-type eye

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein mab-21-like 2

Gene names

    • Name
      mab21l2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q8UUZ1

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: Predominantly localizes to the nucleus, with some cytoplasmic localization (PubMed:25719200).

Keywords

Phenotypes & Variants

Disruption phenotype

Severe lens and retinal defects leading to lethality.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis51-52Mild lens phenotype and severe coloboma. A small number of fish survive to adulthood.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003127891-359Protein mab-21-like 2

Proteomic databases

Expression

Developmental stage

Expressed from 11 hours post-fertilization (hpf). Expression in the midbrain and optic primordia begins at the onset of segmentation and increases to 14 hpf, remaining strong during lateral migration of the optic primordia. Expressed in the neural tube and the oblongated retinal epithelium from 18 hpf. Expression within the differentiating eyes subsequently decreases from 22 hpf to 35 hpf, with only weak expression at the edge of the lens observed from 35 hpf to 48 hpf. Expressed in the branchial pouches from 22 hpf, and in the pharyngeal arches, ganglia and hindbrain and spinal cord neurons from 24 hpf. Expressed in the lens perimeter and the differentiated amacrine and ganglion cell layers at 72 hpf.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the mab-21 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    359
  • Mass (Da)
    41,014
  • Last updated
    2002-03-01 v1
  • Checksum
    B1E7B8CE3709337C
MIATQAKLVYQLNKYYNERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEGMEVIAPNEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFAEAENRLLMSGCRKKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALETAAKQTWRLAREILTNAKSLDKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY038031
EMBL· GenBank· DDBJ
AAK71495.1
EMBL· GenBank· DDBJ
mRNA
AY048748
EMBL· GenBank· DDBJ
AAL09174.1
EMBL· GenBank· DDBJ
Genomic DNA
BC065628
EMBL· GenBank· DDBJ
AAH65628.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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