Q8UUZ1 · MB212_DANRE
- ProteinProtein mab-21-like 2
- Genemab21l2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids359 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | camera-type eye development | |
Biological Process | closure of optic fissure | |
Biological Process | cornea development in camera-type eye | |
Biological Process | embryonic cranial skeleton morphogenesis | |
Biological Process | embryonic eye morphogenesis | |
Biological Process | enteric nervous system development | |
Biological Process | eye development | |
Biological Process | lens development in camera-type eye | |
Biological Process | lens morphogenesis in camera-type eye | |
Biological Process | optic cup morphogenesis involved in camera-type eye development | |
Biological Process | retina development in camera-type eye |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameProtein mab-21-like 2
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ8UUZ1
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Severe lens and retinal defects leading to lethality.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 51-52 | Mild lens phenotype and severe coloboma. A small number of fish survive to adulthood. | ||||
Sequence: Missing |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000312789 | 1-359 | Protein mab-21-like 2 | |||
Sequence: MIATQAKLVYQLNKYYNERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEGMEVIAPNEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFAEAENRLLMSGCRKKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALETAAKQTWRLAREILTNAKSLDKL |
Proteomic databases
Expression
Developmental stage
Expressed from 11 hours post-fertilization (hpf). Expression in the midbrain and optic primordia begins at the onset of segmentation and increases to 14 hpf, remaining strong during lateral migration of the optic primordia. Expressed in the neural tube and the oblongated retinal epithelium from 18 hpf. Expression within the differentiating eyes subsequently decreases from 22 hpf to 35 hpf, with only weak expression at the edge of the lens observed from 35 hpf to 48 hpf. Expressed in the branchial pouches from 22 hpf, and in the pharyngeal arches, ganglia and hindbrain and spinal cord neurons from 24 hpf. Expressed in the lens perimeter and the differentiated amacrine and ganglion cell layers at 72 hpf.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length359
- Mass (Da)41,014
- Last updated2002-03-01 v1
- ChecksumB1E7B8CE3709337C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY038031 EMBL· GenBank· DDBJ | AAK71495.1 EMBL· GenBank· DDBJ | mRNA | ||
AY048748 EMBL· GenBank· DDBJ | AAL09174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC065628 EMBL· GenBank· DDBJ | AAH65628.1 EMBL· GenBank· DDBJ | mRNA |