Q8UHX5 · NTPPA_AGRFC

Function

function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for site, active site.

Type
IDPosition(s)Description
Site16Important for substrate specificity
Active site80Proton acceptor
Site81Important for substrate specificity
Site164Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondTTP diphosphatase activity
Molecular FunctionUTP diphosphatase activity
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dTTP/UTP pyrophosphatase
  • EC number
  • Short names
    dTTPase/UTPase
  • Alternative names
    • Nucleoside triphosphate pyrophosphatase
    • Nucleotide pyrophosphatase
      (Nucleotide PPase
      )

Gene names

    • Name
      maf1
    • ORF names
      AGR_C_943
    • Ordered locus names
      Atu0533

Organism names

Accessions

  • Primary accession
    Q8UHX5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001229871-207dTTP/UTP pyrophosphatase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the Maf family. YhdE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    22,658
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    871063E2F88C346A4D94C233FD385633
MTNSKQKLVLASGSPRRLELLHQIGIEPARLMPMDIDETPVKLEHPRTLCRRLSQQKAEAAQAALKSEQAWKDAYVLGSDTVVAVGRRIVGKAEYTEEASAALHLLSGRSHWVYTGICLVTPDGKIRQKVAETKVRFKRLSTREIDAYIASGQWRGKAGAYGIQGIAGAFVQKLTGSYTNVVGLPLYETMSLLSGEGFEVTSGWLEG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE007869
EMBL· GenBank· DDBJ
AAK86347.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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