Q8U8Z9 · HUTU_AGRFC
- ProteinUrocanate hydratase
- GenehutU
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids557 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity
- 4-imidazolone-5-propanoate = trans-urocanate + H2O
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 52-53 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 130 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 176-178 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 196 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 201 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 242-243 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 263-267 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 273-274 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 322 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 410 | ||||
Binding site | 492 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | urocanate hydratase activity | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrocanate hydratase
- EC number
- Short namesUrocanase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Agrobacterium > Agrobacterium tumefaciens complex
Accessions
- Primary accessionQ8U8Z9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000207330 | 1-557 | Urocanate hydratase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length557
- Mass (Da)61,032
- Last updated2002-08-13 v2
- ChecksumAB948C639ED9D2E5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE007870 EMBL· GenBank· DDBJ | AAK89489.2 EMBL· GenBank· DDBJ | Genomic DNA |