Q8U8Z9 · HUTU_AGRFC

Function

function

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site52-53NAD+ (UniProtKB | ChEBI)
Binding site130NAD+ (UniProtKB | ChEBI)
Binding site176-178NAD+ (UniProtKB | ChEBI)
Binding site196NAD+ (UniProtKB | ChEBI)
Binding site201NAD+ (UniProtKB | ChEBI)
Binding site242-243NAD+ (UniProtKB | ChEBI)
Binding site263-267NAD+ (UniProtKB | ChEBI)
Binding site273-274NAD+ (UniProtKB | ChEBI)
Binding site322NAD+ (UniProtKB | ChEBI)
Active site410
Binding site492NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionurocanate hydratase activity
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocanate hydratase
  • EC number
  • Short names
    Urocanase
  • Alternative names
    • Imidazolonepropionate hydrolase

Gene names

    • Name
      hutU
    • ORF names
      AGR_L_1830
    • Ordered locus names
      Atu3931

Organism names

Accessions

  • Primary accession
    Q8U8Z9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002073301-557Urocanate hydratase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the urocanase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    557
  • Mass (Da)
    61,032
  • Last updated
    2002-08-13 v2
  • Checksum
    AB948C639ED9D2E5
MNNPRHNIRDVRAPQGTELNAKSWMTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAARTWDDFDRIVATLKDLNEDETLIVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYDGNLKGKWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRVDFRLRTRYVDAKAHTLDEALALIDQWTKAGEAKSVGLIGNAAEIFPELFRRGVRPDIVTDQTSAHDPIHGYLPAGWTVAEWRAKQESDPKAVAAAARASMKVHVQAMVDFWNAGVPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARERIAFQGLPARICWVGLGDRHRLGLAFNEMVRNGELKAPVVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVICADGTDDAARRLERVLWNDPATGVMRHADAGYDIAVECAKEQGLRLPGILGN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE007870
EMBL· GenBank· DDBJ
AAK89489.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help