Q8U3N1 · Q8U3N1_PYRFU

Function

function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site100ATP (UniProtKB | ChEBI)
Binding site139ATP (UniProtKB | ChEBI)
Binding site170-173ATP (UniProtKB | ChEBI)
Binding site178ATP (UniProtKB | ChEBI)
Binding site256-257ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-(carboxyamino)imidazole ribonucleotide synthase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylaminoimidazole carboxylase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N5-carboxyaminoimidazole ribonucleotide synthase
  • EC number
  • Short names
    N5-CAIR synthase
  • Alternative names
    • 5-(carboxyamino)imidazole ribonucleotide synthetase

Gene names

    • Name
      purK
    • Ordered locus names
      PF0426

Organism names

Accessions

  • Primary accession
    Q8U3N1

Proteomes

PTM/Processing

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain104-286ATP-grasp

Sequence similarities

Belongs to the PurK/PurT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    372
  • Mass (Da)
    41,099
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    9C1B6D239F5B9CDA52CDC28FF088401A
MIVGILGGGQLAKMMAQEAKKMGFKVAILDPQEEPPAKGVSDYHILGSFKDEKAIRKLAEISDVLTYDIEHINVQALKELEKEGVQIYPSPRVLEIIQDKLVQMQVMKEAGIPVPRFIKADKDELVDKALEFGFPLVQKTRREGYDGKGVAVIRDKSELAKLIPADSMLQEFVNIEKEIAVMVARDQEGNTVAYPVVEMTFNEANILDMLIAPARIEEEIAEEAKRIAIKAVKALDGVGIFGVEMFLTKDGEVYLNEIAPRPHNSGHYTIEACLTSQFEQHIRAITGLPLGSSELLIPAVMFNLLGEGNGKPKVIGMKEALKFPGVYVHIYGKSVVKPLRKMGHVTVVNRNLEKALEIAHKVKKVIKVVGDA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009950
EMBL· GenBank· DDBJ
AAL80550.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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