Q8TXX9 · PYRC_METKA

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

142650100150200250300350400
Type
IDPosition(s)Description
Binding site61Zn2+ 1 (UniProtKB | ChEBI)
Binding site63Zn2+ 1 (UniProtKB | ChEBI)
Binding site63-65substrate
Binding site95substrate
Binding site146Zn2+ 1 (UniProtKB | ChEBI)
Binding site146Zn2+ 2 (UniProtKB | ChEBI)
Binding site180Zn2+ 2 (UniProtKB | ChEBI)
Binding site229Zn2+ 2 (UniProtKB | ChEBI)
Active site297
Binding site297Zn2+ 1 (UniProtKB | ChEBI)
Binding site301substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • Ordered locus names
      MK0530

Organism names

Accessions

  • Primary accession
    Q8TXX9

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001472711-426Dihydroorotase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    426
  • Mass (Da)
    47,525
  • Last updated
    2002-06-01 v1
  • Checksum
    9B1AF1432C41557B
MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDLHVHCRDPHPDYPFGFKTETRRFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIEVIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPWSTLPEIFRELSPDGPLTIFHPELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAKGADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAPHILEDEFEDVPSGVTGGEIILPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAVGKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPVKLIDGTKVYDLKESRREGKPVILEGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009439
EMBL· GenBank· DDBJ
AAM01745.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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