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Q8TXW5 · SYT_METKA

Function

function

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

162450100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site289Zn2+ (UniProtKB | ChEBI)
Binding site340Zn2+ (UniProtKB | ChEBI)
Binding site467Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionthreonine-tRNA ligase activity
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological Processthreonyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Threonine--tRNA ligase
  • EC number
  • Alternative names
    • Threonyl-tRNA synthetase
      (ThrRS
      )

Gene names

    • Name
      thrS
    • Ordered locus names
      MK0544

Organism names

Accessions

  • Primary accession
    Q8TXW5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001011021-624Threonine--tRNA ligase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-143Editing domain
Region197-499Catalytic
Region598-624Disordered

Domain

The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    624
  • Mass (Da)
    71,462
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    0C6B12E074E0C32E6844182CC2CD60AB
MRLLFIHADEMSFEARQKTKIAEEEPPIKEAEVEDCLVVFAAVQEADEENPKAIAEAAVEEIEDVAGELKADRIVLYPYAHLADDLASPDVAVEVLKRMEGLLKERGYEVVRAPFGWYKAFRLACKGHPLSELSRTVTPEAAEEAEEEKIESEFLVYMDGELIPVEEVDLSELPEDFRHLVMHELGEERETGDEEPAHVKLMREKEICDHEPAADVGHVRWYPKGHVVRRCLAEYVENLMADLGAAVVETPVMYDLSEDAIREHADKFGERQYRIRAGNRALMLRYAACFGAFRLLADTTLSRRHLPLKIYELSQSFRLEQSGEVVGLKRLRAFTMPDLHTVCADMDEAVEEFLEQAKLCLEVGLDLGLEYEVVFRTTEKFLKERKEVLEELAEAMEKAYGDAKPVLVEVLPERKHYWECKVDFAFIDSLGRPIENPTVQIDVESGRRFGITYADESGDERHPVILHCSPTGSLERVICAILEGQYKRFEQEGKLPTLPTWLSPVQARVIPVSEKVLEEAEKVFEELKSEGFRVDLDDRDEPVGRKIRDAGEEWVPYVIVIGEEEVKKGTLSVTIREESTLKEQRREEMTLEELVERLERETEGKPRVPLTIPDRLSRRPRFGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009439
EMBL· GenBank· DDBJ
AAM01759.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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