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Q8TX28 · SYM_METKA

Function

function

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

166850100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site146Zn2+ (UniProtKB | ChEBI)
Binding site149Zn2+ (UniProtKB | ChEBI)
Binding site159Zn2+ (UniProtKB | ChEBI)
Binding site162Zn2+ (UniProtKB | ChEBI)
Binding site335ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentaminoacyl-tRNA synthetase multienzyme complex
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionmethionine-tRNA ligase activity
Molecular FunctiontRNA binding
Biological Processmethionyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine--tRNA ligase
  • EC number
  • Alternative names
    • Methionyl-tRNA synthetase
      (MetRS
      )

Gene names

    • Name
      metG
    • Ordered locus names
      MK0850

Organism names

Accessions

  • Primary accession
    Q8TX28

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001391881-668Methionine--tRNA ligase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif, domain.

Type
IDPosition(s)Description
Motif11-21'HIGH' region
Motif332-336'KMSKS' region
Domain567-668tRNA-binding

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    668
  • Mass (Da)
    77,387
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    7964850268F5645D087B512D8012FC61
MGKVLVTTALAYTNGPLHIGHVRSTYLPADVYTRFLKMRGIDAIHIGGTDNHGVPIALQAELEGKDPEEIVEKYHEMIKEDLERLNIHFDEFSCTCREFNPDHVDMTQWFFKRLYEAGYIEEREVEQLYCPECERPLPDRYVEGVCPYCGAEGARGDHCEACGRYLEPVQLEEPRCVICGSKPEVRRTMHLFFKLSEFEEDLKKWLESNDNLPKNVRNYAIQWVREGLKDWDIVRDLDWGVPVPLEGYEDKVFYVWFDAPIGYVTFTKQYCDRVGQDWKDYWFSEDTKIVHFIGKDIIVHHALFWPAMLMGVGATLPYTIVAGEYLTLEGEKMSTSRGWVVWVKDFTKLFPADLLRYYLIVVSPLTRDADFSWGDFRDRVNNELVANLGNFVYRTLSFIYRFLDGNVPEAETDQEIVDKIKETHQRVTEHLEKFRFREALTEVLRLSKFGNEYFQEHEPWKLKDEDPERCAEVLRGCARIVKALAVMLAPFLPDSAEKIWQSLGYEDSVHDVDWEEALEDVETKEIPEPEPIFPKVTEEDLEKAKALLPEESGESEGQDDEYVSLEEFNRLDLRVGKIKEAERVEGSDRLIKLRIDIGDRTVTAVAGLYPTYEPEELVGRKVVVLANIQPKEMFGVRSEAMILAVGDEPALLTIDESKREVEPGERIR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009439
EMBL· GenBank· DDBJ
AAM02063.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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