Q8TJA9 · HPPA1_METAC
- ProteinPutative K(+)-stimulated pyrophosphate-energized sodium pump
- GenehppA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids676 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.
Catalytic activity
- Na+(in) + diphosphate + H2O = Na+(out) + 2 phosphate + H+Na+ (in)CHEBI:29101
+ CHEBI:33019 + CHEBI:15377 = Na+ (out)CHEBI:29101+ 2 CHEBI:43474 + CHEBI:15378
Cofactor
Activity regulation
Requires K+ for maximal activity.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 180 | Important for ion transport | ||||
Sequence: R | ||||||
Binding site | 188 | substrate | ||||
Sequence: K | ||||||
Binding site | 191 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 195 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 218 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 221 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 225 | Important for ion transport | ||||
Sequence: D | ||||||
Site | 232 | Important for ion transport | ||||
Sequence: D | ||||||
Binding site | 433 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 463 | Important for potassium dependence | ||||
Sequence: A | ||||||
Binding site | 617 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 643 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 647 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 650 | substrate | ||||
Sequence: K | ||||||
Site | 651 | Important for ion transport | ||||
Sequence: D | ||||||
Site | 662 | Important for ion transport | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | potassium ion binding | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative K(+)-stimulated pyrophosphate-energized sodium pump
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina
Accessions
- Primary accessionQ8TJA9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 3-23 | Helical | ||||
Sequence: MLIYLAPICALIGLIFAGISY | ||||||
Transmembrane | 58-78 | Helical | ||||
Sequence: IAVFVVFLAIIIALILPNGAL | ||||||
Transmembrane | 83-103 | Helical | ||||
Sequence: FVFGAVLSATAGYAGMLTATI | ||||||
Transmembrane | 129-149 | Helical | ||||
Sequence: VMGMSVVGLGLFGLSLSFIIL | ||||||
Transmembrane | 158-178 | Helical | ||||
Sequence: LLTIVNIVAGFSLGASSIALF | ||||||
Transmembrane | 241-261 | Helical | ||||
Sequence: ILATMLLAASTAATTFPNIPV | ||||||
Transmembrane | 265-285 | Helical | ||||
Sequence: ILVPLIISAIGILASIVGTFF | ||||||
Transmembrane | 303-323 | Helical | ||||
Sequence: GLIAAIILTVIASYFVTSMLL | ||||||
Transmembrane | 327-347 | Helical | ||||
Sequence: GLNVFFATVAGLVAGFLIGQI | ||||||
Transmembrane | 390-410 | Helical | ||||
Sequence: VIISIAIYIAFQLSGLYGIAI | ||||||
Transmembrane | 411-431 | Helical | ||||
Sequence: AAVGMLATLGISLSVDAYGPV | ||||||
Transmembrane | 469-489 | Helical | ||||
Sequence: FAIGSAALTALALFASYGIAV | ||||||
Transmembrane | 501-521 | Helical | ||||
Sequence: VFIGLTIGAMLPYLFSSMTIL | ||||||
Transmembrane | 572-592 | Helical | ||||
Sequence: GLLAVIAPLLVGLVLGPGALG | ||||||
Transmembrane | 593-613 | Helical | ||||
Sequence: GLLAGSVASGFMIAITMSNAG | ||||||
Transmembrane | 656-676 | Helical | ||||
Sequence: AINILIKLMSIVAVVFAPLFM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000217006 | 1-676 | Putative K+-stimulated pyrophosphate-energized sodium pump | |||
Sequence: MDMLIYLAPICALIGLIFAGISYKNVQNEGAGNDLIKKITASIHGGAMVYLNRQYRAIAVFVVFLAIIIALILPNGALTAACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAFRVSFASGTVMGMSVVGLGLFGLSLSFIILESVYTDLDLLTIVNIVAGFSLGASSIALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGSILATMLLAASTAATTFPNIPVENVILVPLIISAIGILASIVGTFFVRTNKTESSAIHMAFNMGLIAAIILTVIASYFVTSMLLGEYGLNVFFATVAGLVAGFLIGQITEHYTSYDRKPTLRVANSCQTGSATNIITGFAKGMESTLWPVVIISIAIYIAFQLSGLYGIAIAAVGMLATLGISLSVDAYGPVADNAGGIAEMSHQKEEVRQITDTLDAVGNTTAAIGKGFAIGSAALTALALFASYGIAVGLSAIDVMNPNVFIGLTIGAMLPYLFSSMTILAVGNAAGEVVVEVRRQFREIAGLMEGKADPDYGKCIAISTHSALKEMIPPGLLAVIAPLLVGLVLGPGALGGLLAGSVASGFMIAITMSNAGGAWDNAKKYIELGNFGGKGSDAHKAGVTGDTVGDPFKDTAGPAINILIKLMSIVAVVFAPLFM |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length676
- Mass (Da)69,277
- Last updated2003-07-25 v2
- Checksum5C7144B63F1F8E26
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE010299 EMBL· GenBank· DDBJ | AAM07230.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |