Q8TJA9 · HPPA1_METAC

Function

function

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Requires K+ for maximal activity.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site180Important for ion transport
Binding site188substrate
Binding site191Mg2+ 1 (UniProtKB | ChEBI)
Binding site195Mg2+ 1 (UniProtKB | ChEBI)
Binding site218Mg2+ 2 (UniProtKB | ChEBI)
Binding site221Mg2+ 2 (UniProtKB | ChEBI)
Site225Important for ion transport
Site232Important for ion transport
Binding site433Mg2+ 2 (UniProtKB | ChEBI)
Site463Important for potassium dependence
Binding site617Ca2+ (UniProtKB | ChEBI)
Binding site643Ca2+ (UniProtKB | ChEBI)
Binding site647Ca2+ (UniProtKB | ChEBI)
Binding site650substrate
Site651Important for ion transport
Site662Important for ion transport

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functiondiphosphate hydrolysis-driven proton transmembrane transporter activity
Molecular Functioninorganic diphosphate phosphatase activity
Molecular Functionmagnesium ion binding
Molecular Functionpotassium ion binding
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative K(+)-stimulated pyrophosphate-energized sodium pump
  • EC number
  • Alternative names
    • Membrane-bound sodium-translocating pyrophosphatase
    • Pyrophosphate-energized inorganic pyrophosphatase
      (Na(+)-PPase
      )

Gene names

    • Name
      hppA1
    • Ordered locus names
      MA_3879

Organism names

Accessions

  • Primary accession
    Q8TJA9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical
Transmembrane58-78Helical
Transmembrane83-103Helical
Transmembrane129-149Helical
Transmembrane158-178Helical
Transmembrane241-261Helical
Transmembrane265-285Helical
Transmembrane303-323Helical
Transmembrane327-347Helical
Transmembrane390-410Helical
Transmembrane411-431Helical
Transmembrane469-489Helical
Transmembrane501-521Helical
Transmembrane572-592Helical
Transmembrane593-613Helical
Transmembrane656-676Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002170061-676Putative K+-stimulated pyrophosphate-energized sodium pump

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    676
  • Mass (Da)
    69,277
  • Last updated
    2003-07-25 v2
  • Checksum
    5C7144B63F1F8E26
MDMLIYLAPICALIGLIFAGISYKNVQNEGAGNDLIKKITASIHGGAMVYLNRQYRAIAVFVVFLAIIIALILPNGALTAACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAFRVSFASGTVMGMSVVGLGLFGLSLSFIILESVYTDLDLLTIVNIVAGFSLGASSIALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGSILATMLLAASTAATTFPNIPVENVILVPLIISAIGILASIVGTFFVRTNKTESSAIHMAFNMGLIAAIILTVIASYFVTSMLLGEYGLNVFFATVAGLVAGFLIGQITEHYTSYDRKPTLRVANSCQTGSATNIITGFAKGMESTLWPVVIISIAIYIAFQLSGLYGIAIAAVGMLATLGISLSVDAYGPVADNAGGIAEMSHQKEEVRQITDTLDAVGNTTAAIGKGFAIGSAALTALALFASYGIAVGLSAIDVMNPNVFIGLTIGAMLPYLFSSMTILAVGNAAGEVVVEVRRQFREIAGLMEGKADPDYGKCIAISTHSALKEMIPPGLLAVIAPLLVGLVLGPGALGGLLAGSVASGFMIAITMSNAGGAWDNAKKYIELGNFGGKGSDAHKAGVTGDTVGDPFKDTAGPAINILIKLMSIVAVVFAPLFM

Sequence caution

The sequence AAM07230.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE010299
EMBL· GenBank· DDBJ
AAM07230.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

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