Q8TFN0 · NDK_EMENI
- ProteinNucleoside diphosphate kinase
- GeneswoH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids153 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11 | ATP (UniProtKB | ChEBI) | |||
Binding site | 59 | ATP (UniProtKB | ChEBI) | |||
Binding site | 87 | ATP (UniProtKB | ChEBI) | |||
Binding site | 93 | ATP (UniProtKB | ChEBI) | |||
Binding site | 104 | ATP (UniProtKB | ChEBI) | |||
Binding site | 114 | ATP (UniProtKB | ChEBI) | |||
Active site | 117 | Pros-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | anisotropic cell growth | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | nucleoside triphosphate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDP kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionQ8TFN0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000137150 | 1-153 | Nucleoside diphosphate kinase | ||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length153
- Mass (Da)16,908
- Last updated2002-06-01 v1
- Checksum213D97818653EA15
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY057453 EMBL· GenBank· DDBJ | AAL23684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACD01000144 EMBL· GenBank· DDBJ | EAA58872.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
BN001302 EMBL· GenBank· DDBJ | CBF74127.1 EMBL· GenBank· DDBJ | Genomic DNA |