Q8TFD3 · DOTC_DOTSE

Function

function

Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963).
One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production (PubMed:22069539).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentvacuolar membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Efflux pump dotC
  • Alternative names
    • Dothistromin biosynthesis protein C

Gene names

    • Name
      dotC

Organism names

Accessions

  • Primary accession
    Q8TFD3

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Vacuole membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-71Helical
Transmembrane94-114Helical
Transmembrane132-152Helical
Transmembrane158-178Helical
Transmembrane186-206Helical
Transmembrane214-234Helical
Transmembrane247-267Helical
Transmembrane280-300Helical
Transmembrane323-343Helical
Transmembrane353-373Helical
Transmembrane385-405Helical
Transmembrane414-434Helical
Transmembrane449-471Helical
Transmembrane524-544Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Decreases the expression of ver1, pksA and vbsA, and subsequent production of dothistromin, but does not affect the resistance to the toxin (PubMed:22069539).

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004434541-585Efflux pump dotC
Glycosylation10N-linked (GlcNAc...) asparagine
Glycosylation91N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression is positively regulated by the dothistromin-specific transcription factor aflR (PubMed:23207690).

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-38Basic and acidic residues
Region1-45Disordered
Region564-585Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    585
  • Mass (Da)
    62,392
  • Last updated
    2009-12-15 v2
  • Checksum
    CA55A4BBB7661099
MSEDHTKADNLSEKDPHSPERSDSSSHEDAHAREEEESSDDDGALDGKPASLIAIVMIALSLIGLQLAVFLSALDTTIVTVALPAISAHFNSTAAYTWVGSAYLLANAASTPIWGKLADIFGRKPMLLLANALFMIGSLVCALSINVGMLITARAIQGAAGGGLLTLVDTIIGDLFSLRTRGTYLGMIGGVWAIACALGPIVGGAFTSSVTWRWCFYINLPIDGLAFGIIFFFLKLKTPKTPILEGFAAIDWAGSFFIIGGTLMFLFGLQYGGITFPWDSATVICLLVFGVVCIVLFGLVEWKFARFPIIPLRLFQYRNNCGALLVAFFHSFVFTSAFYYLPLYFQAVKGATPILAGVYILPAVLSTGVSAAATGAFIGNTGNYLIPMYFGMSMMILGYGLLINFDAGSGWAKLIIYQLIAGIGNGPNFQAPLVALQTKIKQSDIATGTATFNFVRNIATAISVVAGQVLYQNQLKKMTSTLQQLGPAASLIAAGDAGANTQAINALPTPQRDLARSAIADALSPMWIMYTAFAAAGLFCILLVSKTELTTTHEVTEVGLEAQKKAEAERKAERQAKDLEKAQKS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-38Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF448056
EMBL· GenBank· DDBJ
AAL87047.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp