Q8TEB9 · RHBL4_HUMAN
- ProteinRhomboid-related protein 4
- GeneRHBDD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids315 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
Activity regulation
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 144 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 195 | |||||
Sequence: H |
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameRhomboid-related protein 4
- EC number
- Short namesRRP4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8TEB9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-21 | Cytoplasmic | ||||
Sequence: MQRRSRGINTGLILLLSQIFH | ||||||
Transmembrane | 22-42 | Helical | ||||
Sequence: VGINNIPPVTLATLALNIWFF | ||||||
Topological domain | 43-106 | Extracellular | ||||
Sequence: LNPQKPLYSSCLSVEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAY | ||||||
Transmembrane | 107-127 | Helical | ||||
Sequence: VITAFSVLTGVVYLLLQFAVA | ||||||
Topological domain | 128-138 | Cytoplasmic | ||||
Sequence: EFMDEPDFKRS | ||||||
Transmembrane | 139-157 | Helical | ||||
Sequence: CAVGFSGVLFALKVLNNHY | ||||||
Topological domain | 158-180 | Extracellular | ||||
Sequence: CPGGFVNILGFPVPNRFACWVEL | ||||||
Transmembrane | 181-201 | Helical | ||||
Sequence: VAIHLFSPGTSFAGHLAGILV | ||||||
Topological domain | 202-315 | Cytoplasmic | ||||
Sequence: GLMYTQGPLKKIMEACAGGFSSSVGYPGRQYYFNSSGSSGYQDYYPHGRPDHYEEAPRNYDTYTAGLSEEEQLERALQASLWDRGNTRNSPPPYGFHLSPEEMRRQRLHRFDSQ |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034454 | 110 | in dbSNP:rs35731955 | |||
Sequence: A → T | ||||||
Mutagenesis | 142 | Enzyme inactivation. Reduces the cleavage of BIK. | ||||
Sequence: G → A | ||||||
Mutagenesis | 144 | Enzyme inactivation. Reduces the cleavage of BIK and TSAP6. Increases TSAP6-mediated exosome secretion. | ||||
Sequence: S → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 431 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000254189 | 1-315 | UniProt | Rhomboid-related protein 4 | |||
Sequence: MQRRSRGINTGLILLLSQIFHVGINNIPPVTLATLALNIWFFLNPQKPLYSSCLSVEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLQFAVAEFMDEPDFKRSCAVGFSGVLFALKVLNNHYCPGGFVNILGFPVPNRFACWVELVAIHLFSPGTSFAGHLAGILVGLMYTQGPLKKIMEACAGGFSSSVGYPGRQYYFNSSGSSGYQDYYPHGRPDHYEEAPRNYDTYTAGLSEEEQLERALQASLWDRGNTRNSPPPYGFHLSPEEMRRQRLHRFDSQ | |||||||
Modified residue (large scale data) | 291 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 300 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 314 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Induction
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with BIK and STEAP3
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8TEB9 | CGRRF1 Q99675 | 3 | EBI-9916444, EBI-2130213 | |
BINARY | Q8TEB9 | CMTM5 Q96DZ9-2 | 3 | EBI-9916444, EBI-11522780 | |
BINARY | Q8TEB9 | CREB3L1 Q96BA8 | 3 | EBI-9916444, EBI-6942903 | |
BINARY | Q8TEB9 | GYPC P04921 | 3 | EBI-9916444, EBI-7797098 | |
BINARY | Q8TEB9 | LPCAT2 Q7L5N7 | 3 | EBI-9916444, EBI-4280011 | |
BINARY | Q8TEB9 | NSDHL Q15738 | 3 | EBI-9916444, EBI-4280135 | |
BINARY | Q8TEB9 | PLEKHB2 Q96CS7 | 3 | EBI-9916444, EBI-373552 | |
BINARY | Q8TEB9 | PPGB Q59EV6 | 3 | EBI-9916444, EBI-14210385 | |
BINARY | Q8TEB9 | RNF5 Q99942 | 4 | EBI-9916444, EBI-348482 | |
BINARY | Q8TEB9 | SEC22B O75396 | 3 | EBI-9916444, EBI-1058865 | |
BINARY | Q8TEB9 | SLC66A2 Q8N2U9 | 3 | EBI-9916444, EBI-3907610 | |
BINARY | Q8TEB9 | TMEM42 Q69YG0 | 3 | EBI-9916444, EBI-12038591 | |
BINARY | Q8TEB9 | TMEM86B Q8N661 | 3 | EBI-9916444, EBI-2548832 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 269-284 | Ubiquitin-binding domain (UBD) | ||||
Sequence: SEEEQLERALQASLWD | ||||||
Region | 283-315 | Disordered | ||||
Sequence: WDRGNTRNSPPPYGFHLSPEEMRRQRLHRFDSQ | ||||||
Region | 301-315 | VCP/p97-interacting motif (VIM) | ||||
Sequence: PEEMRRQRLHRFDSQ | ||||||
Compositional bias | 301-315 | Basic and acidic residues | ||||
Sequence: PEEMRRQRLHRFDSQ |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8TEB9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length315
- Mass (Da)35,823
- Last updated2002-06-01 v1
- ChecksumAF81BA8D907BDC63
Q8TEB9-2
- Name2
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_021203 | 1-209 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_021204 | 210-218 | in isoform 2 | |||
Sequence: LKKIMEACA → MPVFLFKPK | ||||||
Sequence conflict | 263 | in Ref. 4; AAI01263 | ||||
Sequence: T → M | ||||||
Compositional bias | 301-315 | Basic and acidic residues | ||||
Sequence: PEEMRRQRLHRFDSQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY640233 EMBL· GenBank· DDBJ | AAU14246.1 EMBL· GenBank· DDBJ | mRNA | ||
AK074258 EMBL· GenBank· DDBJ | BAB85031.1 EMBL· GenBank· DDBJ | mRNA | ||
AC010735 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC073149 EMBL· GenBank· DDBJ | AAY24060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC027900 EMBL· GenBank· DDBJ | AAH27900.1 EMBL· GenBank· DDBJ | mRNA | ||
BC062636 EMBL· GenBank· DDBJ | AAH62636.1 EMBL· GenBank· DDBJ | mRNA | ||
BC089404 EMBL· GenBank· DDBJ | AAH89404.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101262 EMBL· GenBank· DDBJ | AAI01263.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101263 EMBL· GenBank· DDBJ | AAI01264.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101264 EMBL· GenBank· DDBJ | AAI01265.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101265 EMBL· GenBank· DDBJ | AAI01266.1 EMBL· GenBank· DDBJ | mRNA | ||
BC111056 EMBL· GenBank· DDBJ | AAI11057.1 EMBL· GenBank· DDBJ | mRNA | ||
AL512717 EMBL· GenBank· DDBJ | CAC21658.2 EMBL· GenBank· DDBJ | mRNA |