Q8TDN6 · BRX1_HUMAN

  • Protein
    Ribosome biogenesis protein BRX1 homolog
  • Gene
    BRIX1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Required for biogenesis of the 60S ribosomal subunit.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentnucleolus
Molecular FunctionRNA binding
Molecular FunctionrRNA binding
Biological Processribosomal large subunit assembly
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribosome biogenesis protein BRX1 homolog
  • Alternative names
    • Brix domain-containing protein 2

Gene names

    • Name
      BRIX1
    • Synonyms
      BRIX, BXDC2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8TDN6
  • Secondary accessions
    • A8K0P5
    • Q3ZTT4
    • Q8N453
    • Q96DH1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 386 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, cross-link, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00001202301-353UniProtRibosome biogenesis protein BRX1 homolog
Cross-link160UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)247PRIDEPhosphoserine
Modified residue (large scale data)259PRIDEPhosphotyrosine
Modified residue261UniProtPhosphoserine
Modified residue (large scale data)261PRIDEPhosphoserine
Modified residue276UniProtN6-acetyllysine
Modified residue (large scale data)309PRIDEPhosphothreonine
Cross-link314UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link322UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8TDN6EBNA1BP2 Q998486EBI-1052326, EBI-1048111
BINARY Q8TDN6HNRNPU Q008392EBI-1052326, EBI-351126
BINARY Q8TDN6RPL13 P263733EBI-1052326, EBI-356849

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-15Basic residues
Region1-46Disordered
Compositional bias16-46Basic and acidic residues
Domain60-249Brix

Sequence similarities

Belongs to the BRX1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    41,401
  • Last updated
    2003-05-09 v2
  • Checksum
    F05597673A13B7CC
MAATKRKRRGGFAVQAKKPKRNEIDAEPPAKRHATAEEVEEEERDRIPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDELPHYALLKELLIQIFSTPRYHPKSQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQRMDSGKTK

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-15Basic residues
Sequence conflict11-27in Ref. 1; AAL83818
Compositional bias16-46Basic and acidic residues
Sequence conflict34in Ref. 1; AAL83818
Sequence conflict286in Ref. 1; AAL83818

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF347667
EMBL· GenBank· DDBJ
AAL83818.1
EMBL· GenBank· DDBJ
mRNA
AY364244
EMBL· GenBank· DDBJ
AAQ76803.1
EMBL· GenBank· DDBJ
mRNA
AK289610
EMBL· GenBank· DDBJ
BAF82299.1
EMBL· GenBank· DDBJ
mRNA
CH471119
EMBL· GenBank· DDBJ
EAW55909.1
EMBL· GenBank· DDBJ
Genomic DNA
BC001546
EMBL· GenBank· DDBJ
AAH01546.2
EMBL· GenBank· DDBJ
mRNA
BC036741
EMBL· GenBank· DDBJ
AAH36741.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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