Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A RBFOX1 or RBFOX3 Gene Variants.
The SNPs rs4787050 and rs8045980 showed a significant association with susceptibility to lung cancer. Moreover cooking oil fume exposure was found to increase the risk of lung cancer.
RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms.
RBFOX1 - strong candidate gene associated with clinical features of Depression (e.g. earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings.
Report a 1.8 A X-ray structure of the free Fox-1 containing six distinct monomers. We use this and the nuclear magnetic resonance (NMR) structure of the Fox-1 protein/RNA complex for molecular dynamics (MD) analyses of the structured hydration. The individual monomers of the X-ray structure show diverse hydration patterns however MD excellently reproduces the most occupied hydration sites.
Our findings suggested rs17648524 (intronic RBFOX1 gene) and rs7084402 (7.5kb 5' of the BICC1 gene) showed gender-specific associations with high myopia in the Han Chinese.
FGF12 RBFOX1 and MIR302F could be important in human heterotaxy because they were noted in multiple cases. Further investigation into genes involved in the NODAL BMP and WNT body patterning pathways and into the dosage effects of FGF12 RBFOX1 and MIR302F is warranted.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs namely the Fox-1 and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex which is subsequently confirmed by NMR and ITC measurements
Data show that while RBFOX1 and RBFOX2 do not mediate neuron-specific processing of UBE3A-ATS these proteins play important roles in developing neurons and are not completely functionally redundant.
study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.