Q8TBF2 · PXL2B_HUMAN

  • Protein
    Prostamide/prostaglandin F synthase
  • Gene
    PRXL2B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the reduction of prostaglandin-ethanolamide H2 (prostamide H2) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H2 to prostaglandin F(2alpha) (By similarity).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular exosome
Cellular Componentmyelin sheath
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Functionprostaglandin F synthase activity
Biological Processprostaglandin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostamide/prostaglandin F synthase
  • EC number
  • Short names
    Prostamide/PG F synthase; Prostamide/PGF synthase
  • Alternative names
    • Peroxiredoxin-like 2B
    • Protein FAM213B

Gene names

    • Name
      PRXL2B
    • Synonyms
      C1orf93, FAM213B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8TBF2
  • Secondary accessions
    • A8K793
    • B3KPY3
    • B4DQR9
    • B4E0S5
    • B7ZAC8

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 264 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002846371-198UniProtProstamide/prostaglandin F synthase
Modified residue108UniProtPhosphotyrosine
Modified residue (large scale data)110PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8TBF2COPS3 Q9UNS25EBI-7280826, EBI-350590
BINARY Q8TBF2TCP11L1 Q9NUJ36EBI-7280826, EBI-2555179

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence & Isoforms

Align isoforms (6)
  • Sequence status
    Complete

This entry describes 6 isoforms produced by Alternative splicing.

Q8TBF2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    198
  • Mass (Da)
    21,223
  • Last updated
    2002-06-01 v1
  • Checksum
    5E846BAFF44BA7FF
MSTVDLARVGACILKHAVTGEAVELRSLWREHACVVAGLRRFGCVVCRWIAQDLSSLAGLLDQHGVRLVGVGPEALGLQEFLDGDYFAGELYLDESKQLYKELGFKRYNSLSILPAALGKPVRDVAAKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV

Q8TBF2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 154-198: GGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV → EVPRRLRPQGAHPAGPGHLCGGLCQRPASV

Q8TBF2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 106-106: K → KRLWTQASPEFGQATWCLR

Q8TBF2-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8TBF2-6

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 130-164: KAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQ → VPTPDRPRLLASRGTCLGTCCRAEGCWWSAK

Q8TBF2-7

  • Name
    6
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 106-106: K → KRLWTQASPEFGQATWCLR
    • 154-198: GGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV → EVPRRLRPQGAHPAGPGHLCGGLCQRPASV

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KPF5J3KPF5_HUMANPRXL2B231
J3KPF6J3KPF6_HUMANPRXL2B213
J3KRV9J3KRV9_HUMANPRXL2B178
A0A2P0CTB1A0A2P0CTB1_HUMANPRXL2B228
A0A2P0CTH9A0A2P0CTH9_HUMANPRXL2B161
A0A2P0CU24A0A2P0CU24_HUMANPRXL2B191
A0A0G2JSF1A0A0G2JSF1_HUMANPRXL2B154
A0A0G2JRR6A0A0G2JRR6_HUMANPRXL2B196
A0A0A0MRV4A0A0A0MRV4_HUMANPRXL2B192
A0A0A0MT35A0A0A0MT35_HUMANPRXL2B246
J3QKK8J3QKK8_HUMANPRXL2B151

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_040901106in isoform 3 and isoform 6
Alternative sequenceVSP_040903129-164in isoform 4
Alternative sequenceVSP_040904130-164in isoform 5
Alternative sequenceVSP_024581154-198in isoform 2 and isoform 6

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK057027
EMBL· GenBank· DDBJ
BAG51845.1
EMBL· GenBank· DDBJ
mRNA
AK075273
EMBL· GenBank· DDBJ
BAC11511.1
EMBL· GenBank· DDBJ
mRNA
AK291908
EMBL· GenBank· DDBJ
BAF84597.1
EMBL· GenBank· DDBJ
mRNA
AK298926
EMBL· GenBank· DDBJ
BAG61031.1
EMBL· GenBank· DDBJ
mRNA
AK303504
EMBL· GenBank· DDBJ
BAG64537.1
EMBL· GenBank· DDBJ
mRNA
AK316243
EMBL· GenBank· DDBJ
BAH14614.1
EMBL· GenBank· DDBJ
mRNA
AF425266
EMBL· GenBank· DDBJ
AAP97295.1
EMBL· GenBank· DDBJ
mRNA
AL139246
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471183
EMBL· GenBank· DDBJ
EAW56086.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471183
EMBL· GenBank· DDBJ
EAW56087.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471183
EMBL· GenBank· DDBJ
EAW56088.1
EMBL· GenBank· DDBJ
Genomic DNA
BC022547
EMBL· GenBank· DDBJ
AAH22547.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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