Q8TBF2 · PXL2B_HUMAN
- ProteinProstamide/prostaglandin F synthase
- GenePRXL2B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids198 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the reduction of prostaglandin-ethanolamide H2 (prostamide H2) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H2 to prostaglandin F(2alpha) (By similarity).
Catalytic activity
- [thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha
RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:57405 = RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:57404
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular exosome | |
Cellular Component | myelin sheath | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Molecular Function | prostaglandin F synthase activity | |
Biological Process | prostaglandin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstamide/prostaglandin F synthase
- EC number
- Short namesProstamide/PG F synthase; Prostamide/PGF synthase
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8TBF2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 264 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000284637 | 1-198 | UniProt | Prostamide/prostaglandin F synthase | |||
Sequence: MSTVDLARVGACILKHAVTGEAVELRSLWREHACVVAGLRRFGCVVCRWIAQDLSSLAGLLDQHGVRLVGVGPEALGLQEFLDGDYFAGELYLDESKQLYKELGFKRYNSLSILPAALGKPVRDVAAKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV | |||||||
Modified residue | 108 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 110 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8TBF2 | COPS3 Q9UNS2 | 5 | EBI-7280826, EBI-350590 | |
BINARY | Q8TBF2 | TCP11L1 Q9NUJ3 | 6 | EBI-7280826, EBI-2555179 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 6 isoforms produced by Alternative splicing.
Q8TBF2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length198
- Mass (Da)21,223
- Last updated2002-06-01 v1
- Checksum5E846BAFF44BA7FF
Q8TBF2-2
- Name2
- Differences from canonical
- 154-198: GGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV → EVPRRLRPQGAHPAGPGHLCGGLCQRPASV
Q8TBF2-3
- Name3
- Differences from canonical
- 106-106: K → KRLWTQASPEFGQATWCLR
Q8TBF2-4
- Name4
- Differences from canonical
- 129-164: Missing
Q8TBF2-6
- Name5
- Differences from canonical
- 130-164: KAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQ → VPTPDRPRLLASRGTCLGTCCRAEGCWWSAK
Q8TBF2-7
- Name6
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
J3KPF5 | J3KPF5_HUMAN | PRXL2B | 231 | ||
J3KPF6 | J3KPF6_HUMAN | PRXL2B | 213 | ||
J3KRV9 | J3KRV9_HUMAN | PRXL2B | 178 | ||
A0A2P0CTB1 | A0A2P0CTB1_HUMAN | PRXL2B | 228 | ||
A0A2P0CTH9 | A0A2P0CTH9_HUMAN | PRXL2B | 161 | ||
A0A2P0CU24 | A0A2P0CU24_HUMAN | PRXL2B | 191 | ||
A0A0G2JSF1 | A0A0G2JSF1_HUMAN | PRXL2B | 154 | ||
A0A0G2JRR6 | A0A0G2JRR6_HUMAN | PRXL2B | 196 | ||
A0A0A0MRV4 | A0A0A0MRV4_HUMAN | PRXL2B | 192 | ||
A0A0A0MT35 | A0A0A0MT35_HUMAN | PRXL2B | 246 | ||
J3QKK8 | J3QKK8_HUMAN | PRXL2B | 151 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_040901 | 106 | in isoform 3 and isoform 6 | |||
Sequence: K → KRLWTQASPEFGQATWCLR | ||||||
Alternative sequence | VSP_040903 | 129-164 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_040904 | 130-164 | in isoform 5 | |||
Sequence: KAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQ → VPTPDRPRLLASRGTCLGTCCRAEGCWWSAK | ||||||
Alternative sequence | VSP_024581 | 154-198 | in isoform 2 and isoform 6 | |||
Sequence: GGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV → EVPRRLRPQGAHPAGPGHLCGGLCQRPASV |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK057027 EMBL· GenBank· DDBJ | BAG51845.1 EMBL· GenBank· DDBJ | mRNA | ||
AK075273 EMBL· GenBank· DDBJ | BAC11511.1 EMBL· GenBank· DDBJ | mRNA | ||
AK291908 EMBL· GenBank· DDBJ | BAF84597.1 EMBL· GenBank· DDBJ | mRNA | ||
AK298926 EMBL· GenBank· DDBJ | BAG61031.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303504 EMBL· GenBank· DDBJ | BAG64537.1 EMBL· GenBank· DDBJ | mRNA | ||
AK316243 EMBL· GenBank· DDBJ | BAH14614.1 EMBL· GenBank· DDBJ | mRNA | ||
AF425266 EMBL· GenBank· DDBJ | AAP97295.1 EMBL· GenBank· DDBJ | mRNA | ||
AL139246 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471183 EMBL· GenBank· DDBJ | EAW56086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471183 EMBL· GenBank· DDBJ | EAW56087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471183 EMBL· GenBank· DDBJ | EAW56088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC022547 EMBL· GenBank· DDBJ | AAH22547.1 EMBL· GenBank· DDBJ | mRNA |