Q8TAX7 · MUC7_HUMAN
- ProteinMucin-7
- GeneMUC7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids377 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | Golgi lumen | |
Cellular Component | plasma membrane | |
Biological Process | antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | killing of cells of another organism |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMucin-7
- Short namesMUC-7
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8TAX7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Asthma (ASTHMA)
- Note
- DescriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
- See alsoMIM:600807
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_050451 | 80 | in dbSNP:rs6826961 | |||
Sequence: N → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 601 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MKTLPLFVCICALSACFSFSEG | ||||||
Chain | PRO_0000239228 | 23-377 | Mucin-7 | |||
Sequence: RERDHELRHRRHHHQSPKSHFELPHYPGLLAHQKPFIRKSYKCLHKRCRPKLPPSPNNPPKFPNPHQPPKHPDKNSSVVNPTLVATTQIPSVTFPSASTKITTLPNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQNKISRFLLYMKNLLNRIIDDMVEQ | ||||||
Glycosylation | 97 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 128 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 135 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 176 | O-linked (GalNAc) threonine; by GALNT13 | ||||
Sequence: T | ||||||
Glycosylation | 182 | O-linked (GalNAc) serine; by GALNT13 | ||||
Sequence: S | ||||||
Glycosylation | 183 | O-linked (GalNAc) serine; by GALNT13 | ||||
Sequence: S | ||||||
Glycosylation | 188 | O-linked (GalNAc) threonine; by GALNT13 | ||||
Sequence: T | ||||||
Glycosylation | 189 | O-linked (GalNAc) threonine; by GALNT13 | ||||
Sequence: T |
Post-translational modification
N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
Gene expression databases
Organism-specific databases
Interaction
Subunit
Monomer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8TAX7 | AMY1C P0DTE7 | 2 | EBI-738582, EBI-738586 | |
BINARY | Q8TAX7 | HTN1 P15515 | 2 | EBI-738582, EBI-738638 | |
BINARY | Q8TAX7 | PRH2 P02810 | 2 | EBI-738582, EBI-738601 | |
BINARY | Q8TAX7 | STATH P02808 | 2 | EBI-738582, EBI-738687 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 70-100 | Disordered | ||||
Sequence: CRPKLPPSPNNPPKFPNPHQPPKHPDKNSSV | ||||||
Compositional bias | 74-92 | Pro residues | ||||
Sequence: LPPSPNNPPKFPNPHQPPK | ||||||
Region | 150-355 | Disordered | ||||
Sequence: SVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQNK | ||||||
Compositional bias | 163-199 | Pro residues | ||||
Sequence: QDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATT | ||||||
Repeat | 165-187 | 1 | ||||
Sequence: TTAAPPTPSATTPAPPSSSAPPE | ||||||
Repeat | 188-210 | 2 | ||||
Sequence: TTAAPPTPSATTQAPPSSSAPPE | ||||||
Compositional bias | 208-245 | Pro residues | ||||
Sequence: PPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATT | ||||||
Repeat | 211-233 | 3 | ||||
Sequence: TTAAPPTPPATTPAPPSSSAPPE | ||||||
Repeat | 234-256 | 4 | ||||
Sequence: TTAAPPTPSATTPAPLSSSAPPE | ||||||
Repeat | 257-279 | 5 | ||||
Sequence: TTAVPPTPSATTLDPSSASAPPE | ||||||
Compositional bias | 262-277 | Polar residues | ||||
Sequence: PTPSATTLDPSSASAP | ||||||
Compositional bias | 278-301 | Pro residues | ||||
Sequence: PETTAAPPTPSATTPAPPSSPAPQ | ||||||
Repeat | 280-302 | 6 | ||||
Sequence: TTAAPPTPSATTPAPPSSPAPQE | ||||||
Compositional bias | 302-355 | Polar residues | ||||
Sequence: ETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQNK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length377
- Mass (Da)39,159
- Last updated2010-05-18 v2
- Checksum1BF92D1855C13F4A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D6RHX1 | D6RHX1_HUMAN | MUC7 | 136 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 70 | in Ref. 4; AA sequence | ||||
Sequence: C → S | ||||||
Compositional bias | 74-92 | Pro residues | ||||
Sequence: LPPSPNNPPKFPNPHQPPK | ||||||
Sequence conflict | 92 | in Ref. 4; AA sequence | ||||
Sequence: K → P | ||||||
Sequence conflict | 162 | in Ref. 4; AA sequence and 5; AA sequence | ||||
Sequence: P → A | ||||||
Compositional bias | 163-199 | Pro residues | ||||
Sequence: QDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATT | ||||||
Compositional bias | 208-245 | Pro residues | ||||
Sequence: PPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATT | ||||||
Compositional bias | 262-277 | Polar residues | ||||
Sequence: PTPSATTLDPSSASAP | ||||||
Compositional bias | 278-301 | Pro residues | ||||
Sequence: PETTAAPPTPSATTPAPPSSPAPQ | ||||||
Compositional bias | 302-355 | Polar residues | ||||
Sequence: ETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQNK | ||||||
Sequence conflict | 334 | in Ref. 3; AAH25688 | ||||
Sequence: T → I |
Polymorphism
The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC106884 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC108518 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC025688 EMBL· GenBank· DDBJ | AAH25688.1 EMBL· GenBank· DDBJ | mRNA |