Q8T9E3 · Q8T9E3_DROME
- ProteinSD04476p
- GeneRhoGEF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2555 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8T9E3
Organism-specific databases
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-247 | Disordered | ||||
Sequence: MTHQSKNDLYTDEHEYDEVQEIPEESSIQPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAGAPQSPVIVVDSVPELPAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLASSLSSLASSLSGHRDRDKDRDKDRENQNAVPPQTPPLPPSYKQNQMNGDSTAAAGGGVSAPATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLA | ||||||
Compositional bias | 26-64 | Polar residues | ||||
Sequence: SSIQPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAG | ||||||
Compositional bias | 101-122 | Polar residues | ||||
Sequence: NKSKIPRSPSLASSLSSLASSL | ||||||
Compositional bias | 123-139 | Basic and acidic residues | ||||
Sequence: SGHRDRDKDRDKDRENQ | ||||||
Compositional bias | 173-247 | Polar residues | ||||
Sequence: PATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLA | ||||||
Domain | 256-332 | PDZ | ||||
Sequence: TLTVRKDSNGYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVKRSQ | ||||||
Region | 339-363 | Disordered | ||||
Sequence: SVSVVTPSTPILSGRDRTASITGPQ | ||||||
Coiled coil | 378-424 | |||||
Sequence: IQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKLREQLHQVGAE | ||||||
Region | 501-520 | Disordered | ||||
Sequence: SLGTRKNKTEKDLTTSSPFG | ||||||
Compositional bias | 529-558 | Polar residues | ||||
Sequence: QRMSHQAESMSQSMHQHTSTPTSQQFFHPH | ||||||
Region | 529-666 | Disordered | ||||
Sequence: QRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQQQLPRSTDNSPSNAKSKRSKIKTKALSDP | ||||||
Compositional bias | 626-653 | Polar residues | ||||
Sequence: RATSPQLNRSQQQQLPRSTDNSPSNAKS | ||||||
Compositional bias | 764-784 | Polar residues | ||||
Sequence: QQQQQHQMSGGQATGALGQTP | ||||||
Region | 764-857 | Disordered | ||||
Sequence: QQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPNENNRGAAA | ||||||
Compositional bias | 792-811 | Basic and acidic residues | ||||
Sequence: RRVGSSPDNMHPRHPDRITK | ||||||
Domain | 1146-1196 | Phorbol-ester/DAG-type | ||||
Sequence: GHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESC | ||||||
Compositional bias | 1229-1244 | Basic and acidic residues | ||||
Sequence: NEKRSRQDEELDVELT | ||||||
Region | 1229-1279 | Disordered | ||||
Sequence: NEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSG | ||||||
Compositional bias | 1262-1279 | Polar residues | ||||
Sequence: DANISIRSNGNTSCNTSG | ||||||
Region | 1346-1399 | Disordered | ||||
Sequence: RRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQL | ||||||
Compositional bias | 1369-1390 | Basic and acidic residues | ||||
Sequence: YKERLSNKRNRNSRRKTSDPSL | ||||||
Compositional bias | 1411-1429 | Polar residues | ||||
Sequence: SSNSSLSSAGGSESPSTSM | ||||||
Region | 1411-1431 | Disordered | ||||
Sequence: SSNSSLSSAGGSESPSTSMEH | ||||||
Coiled coil | 1521-1548 | |||||
Sequence: AAEVLAALTDAEKKRQEIINEIYQTERN | ||||||
Domain | 1534-1729 | DH | ||||
Sequence: KRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQA | ||||||
Compositional bias | 1874-1891 | Polar residues | ||||
Sequence: QSKNRSKNASSNHDTSIS | ||||||
Region | 1874-1894 | Disordered | ||||
Sequence: QSKNRSKNASSNHDTSISDPA | ||||||
Region | 1940-1993 | Disordered | ||||
Sequence: APATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRS | ||||||
Region | 2011-2042 | Disordered | ||||
Sequence: VTLRHSQSTRESVRPGSTGEERNSTYGMVGGN | ||||||
Region | 2186-2221 | Disordered | ||||
Sequence: LRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQIPPSR | ||||||
Region | 2250-2425 | Disordered | ||||
Sequence: RLPAIPSKPHERPTTPLAPFNTEPKTSQSVIDASKRQSTDAVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKNEAAASVDELPSQSREIKTAENASKSVADKKEDNEETIEEGVASTVDSSTQTSPTESPKETDKLTGGSSSTCGPNR | ||||||
Compositional bias | 2268-2285 | Polar residues | ||||
Sequence: PFNTEPKTSQSVIDASKR | ||||||
Compositional bias | 2298-2344 | Basic and acidic residues | ||||
Sequence: QEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVAD | ||||||
Compositional bias | 2345-2370 | Polar residues | ||||
Sequence: PTTSKNEAAASVDELPSQSREIKTAE | ||||||
Compositional bias | 2371-2387 | Basic and acidic residues | ||||
Sequence: NASKSVADKKEDNEETI | ||||||
Compositional bias | 2390-2425 | Polar residues | ||||
Sequence: GVASTVDSSTQTSPTESPKETDKLTGGSSSTCGPNR | ||||||
Coiled coil | 2459-2486 | |||||
Sequence: INERDMERERLRKENQHLRELLSALHDR | ||||||
Region | 2514-2555 | Disordered | ||||
Sequence: IDAISNSSLTPTPTPIPTASPSASGQVETAEAMRITSTEDEE | ||||||
Compositional bias | 2516-2546 | Polar residues | ||||
Sequence: AISNSSLTPTPTPIPTASPSASGQVETAEAM |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,555
- Mass (Da)280,433
- Last updated2002-06-01 v1
- Checksum6D540E415F16AC2D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-64 | Polar residues | ||||
Sequence: SSIQPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAG | ||||||
Compositional bias | 101-122 | Polar residues | ||||
Sequence: NKSKIPRSPSLASSLSSLASSL | ||||||
Compositional bias | 123-139 | Basic and acidic residues | ||||
Sequence: SGHRDRDKDRDKDRENQ | ||||||
Compositional bias | 173-247 | Polar residues | ||||
Sequence: PATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLA | ||||||
Compositional bias | 529-558 | Polar residues | ||||
Sequence: QRMSHQAESMSQSMHQHTSTPTSQQFFHPH | ||||||
Compositional bias | 626-653 | Polar residues | ||||
Sequence: RATSPQLNRSQQQQLPRSTDNSPSNAKS | ||||||
Compositional bias | 764-784 | Polar residues | ||||
Sequence: QQQQQHQMSGGQATGALGQTP | ||||||
Compositional bias | 792-811 | Basic and acidic residues | ||||
Sequence: RRVGSSPDNMHPRHPDRITK | ||||||
Compositional bias | 1229-1244 | Basic and acidic residues | ||||
Sequence: NEKRSRQDEELDVELT | ||||||
Compositional bias | 1262-1279 | Polar residues | ||||
Sequence: DANISIRSNGNTSCNTSG | ||||||
Compositional bias | 1369-1390 | Basic and acidic residues | ||||
Sequence: YKERLSNKRNRNSRRKTSDPSL | ||||||
Compositional bias | 1411-1429 | Polar residues | ||||
Sequence: SSNSSLSSAGGSESPSTSM | ||||||
Compositional bias | 1874-1891 | Polar residues | ||||
Sequence: QSKNRSKNASSNHDTSIS | ||||||
Compositional bias | 2268-2285 | Polar residues | ||||
Sequence: PFNTEPKTSQSVIDASKR | ||||||
Compositional bias | 2298-2344 | Basic and acidic residues | ||||
Sequence: QEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVAD | ||||||
Compositional bias | 2345-2370 | Polar residues | ||||
Sequence: PTTSKNEAAASVDELPSQSREIKTAE | ||||||
Compositional bias | 2371-2387 | Basic and acidic residues | ||||
Sequence: NASKSVADKKEDNEETI | ||||||
Compositional bias | 2390-2425 | Polar residues | ||||
Sequence: GVASTVDSSTQTSPTESPKETDKLTGGSSSTCGPNR | ||||||
Compositional bias | 2516-2546 | Polar residues | ||||
Sequence: AISNSSLTPTPTPIPTASPSASGQVETAEAM |