Q8T5G8 · CHS_MELAT
- ProteinChitin synthase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1851 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Required for the synthesis of chitin.
Catalytic activity
- [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H+ + UDP
[(1→4)-N-acetyl-β-D-glucosaminyl](n) RHEA-COMP:9593 + CHEBI:57705 = [(1→4)-N-acetyl-β-D-glucosaminyl](n+1) RHEA-COMP:9595 + CHEBI:15378 + CHEBI:58223
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell septum | |
Cellular Component | plasma membrane | |
Molecular Function | chitin synthase activity | |
Biological Process | cell wall chitin biosynthetic process | |
Biological Process | embryo development ending in birth or egg hatching |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameChitin synthase
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne
Accessions
- Primary accessionQ8T5G8
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-108 | Cytoplasmic | ||||
Sequence: MQYHQHQHQFPGPGPSHTSVYSSDGFSCSMESIPLPEHLQQRNPPMEEHYLQQTILPTRVPESTVAKAREIVLSHITSQEHLPWDTFRLLPPKADRHQKDTLYNGFLQ | ||||||
Transmembrane | 109-129 | Helical | ||||
Sequence: VLKMITFVALFVTTLGSSILA | ||||||
Topological domain | 130-168 | Extracellular | ||||
Sequence: KLSLLVMAAGLGQAGHNISICPDKIPESPKNSVLISPKN | ||||||
Transmembrane | 169-189 | Helical | ||||
Sequence: AAKWAWALLLAICIPELLCFA | ||||||
Topological domain | 190-208 | Cytoplasmic | ||||
Sequence: RSLHRSLFRKVRGPSFLQF | ||||||
Transmembrane | 209-229 | Helical | ||||
Sequence: LLVFTVESVHAFGLGALVFAI | ||||||
Topological domain | 230-234 | Extracellular | ||||
Sequence: MPRGM | ||||||
Transmembrane | 235-255 | Helical | ||||
Sequence: VITMLQLGNSLCLIPSLLLPL | ||||||
Topological domain | 256-261 | Cytoplasmic | ||||
Sequence: SRSRSR | ||||||
Transmembrane | 262-282 | Helical | ||||
Sequence: WLPLLLLLDGSAILAQSSAAI | ||||||
Topological domain | 283-291 | Extracellular | ||||
Sequence: WRGSIPLER | ||||||
Transmembrane | 292-312 | Helical | ||||
Sequence: FGFVFLCTSLISIAWWQNFVH | ||||||
Topological domain | 313-337 | Cytoplasmic | ||||
Sequence: PHSFLPATRFFAHYAAKLRECRSKT | ||||||
Transmembrane | 338-358 | Helical | ||||
Sequence: FVVLSPWKCLIFTFCMFQFVP | ||||||
Topological domain | 359-544 | Extracellular | ||||
Sequence: PQIPFRELLQKDPFGEKLVTINAYNLNQSQLNAFQERMENLERKAFHQQHPHIVHPLKLNRKIVENIANGEAALFRNGTRRPPKKEEVKKNKMDSKKKTKKLKKKKGGNNNATSTNSSEKTPTKGGVLPTKRERRTMAATGSNERVEADYSSNSDADEQEEEEENVAAYNIYDDRVELNQFTTAND | ||||||
Transmembrane | 545-565 | Helical | ||||
Sequence: ALWLVFVQAGSVLLCQLCAKF | ||||||
Topological domain | 566-573 | Cytoplasmic | ||||
Sequence: ACKVVMQR | ||||||
Transmembrane | 574-594 | Helical | ||||
Sequence: VGLALPVVLSIPFGILFLAYS | ||||||
Topological domain | 595-631 | Extracellular | ||||
Sequence: CRQKATNPCHLSEWMSKELFWQCPTRPFHWQRFFREQ | ||||||
Transmembrane | 632-652 | Helical | ||||
Sequence: PNLLWLCWWLSQCWITIHLWL | ||||||
Topological domain | 653-1124 | Cytoplasmic | ||||
Sequence: PRQERLAKSEKLFVLGYIDAPFPEHSIALDRRRDDKIQIRSEDIDTEEEANEGGGEQEDGNSSTHTCESAASGLVVVEAPFPKHPNVGRPTAASICSNGSLSSGSHRSDDGGLIRELPSSADSVCKIYVCATMWHESALEMGCMLKSIFRLDKDQCARRNAQRYLKVVDPDYYVFEAHIYIDDAFELDENGNPHPNKFVHQLLEKMDEAASTKLQLRTPRICVTSYGGRISYVLPWRNRLSIHLKNKLLIRQRKRWSQVMYLYFLLGFRLMLRVHEQKRRELLAENTFILTLDGDVDFQPECVHLLVDLMRKNRRLGAACGRIHPRGSGLMVWYQKFEYAVGHWLQKATEHMIGCVLCSPGCFSLFRSSALIDDNVARKYATKSEKPFHYVQYDQGEDRWLCTLLLQRGYRVEYCAASDALTFAPEGFSEFFNQRRRWIPSTMANVIDLLRDYRNVVRVNDSVSIWYIAYQL | ||||||
Transmembrane | 1125-1145 | Helical | ||||
Sequence: VMLFSSVLGPGTIFLMIVGAI | ||||||
Topological domain | 1146-1154 | Extracellular | ||||
Sequence: SISFNIDTR | ||||||
Transmembrane | 1155-1175 | Helical | ||||
Sequence: LALLIVTTPVLCFCVCCLTCG | ||||||
Topological domain | 1176-1179 | Cytoplasmic | ||||
Sequence: TETQ | ||||||
Transmembrane | 1180-1200 | Helical | ||||
Sequence: LLLAQVIGALFAMLMTAVIVG | ||||||
Topological domain | 1201-1209 | Extracellular | ||||
Sequence: TSLQIQKDG | ||||||
Transmembrane | 1210-1230 | Helical | ||||
Sequence: LLSPHSIFLFTVLGSWSFSAL | ||||||
Topological domain | 1231-1235 | Cytoplasmic | ||||
Sequence: LHPLE | ||||||
Transmembrane | 1236-1256 | Helical | ||||
Sequence: FGCLLPCGLYFLAIPCMYMLL | ||||||
Topological domain | 1257-1461 | Extracellular | ||||
Sequence: PVYSLCNLNTVSWGTRENASVSSSSTGQFSGKREERGDILPHLQKTEDGELSVGCGNFCRVVCCVRNPSSPPCADETVEVRKLDENFRKIERKLQSLERRTNGQGNNAEEEGKEEEETGKSEQERKEGREEGKEEEGKMSKRKKEEMDLKGWMELEPFRRFEPIVLDTEEESFWREMIEKYLRPILPNSNEQARIQRGLNELRNT | ||||||
Transmembrane | 1462-1482 | Helical | ||||
Sequence: CCSAFFMVNIVFIIVVLVLQL | ||||||
Topological domain | 1483-1527 | Cytoplasmic | ||||
Sequence: QKDCLHIEWPLGPLVNQTRVQCGGGGGRDFEGEEWIMSRLQLEPM | ||||||
Transmembrane | 1528-1548 | Helical | ||||
Sequence: GFVFIVFFLIILFIQFLAMLF | ||||||
Topological domain | 1549-1851 | Extracellular | ||||
Sequence: HRFGTFTHIIASTELCCAQRPLDKLSEEELVAQNAVEIVRELQAIRGIDSSLSRSEQFQQQPLQRQTRQHFPRTLSLGKRQQNAQIPPRCEKGGNERGEESPTSLPAPPVINWSEVHRNHQRVQPMEGGQQFDPRKDTLDAAFRQRFFALSSSSIAADHHQNNGGHLVDTTGTGHIGAAALPLTLNRRTLRALEQRRNILYQRGDRKRIPALNQQFHSIFPSSSESEGEEGEGGGRGRGREQERDKCLEGKKEKFRQRVEEGPARCHRLEELFGKSRKGGPQKRGKVNGENMKFLGTTNKRAK |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown causes a delay in egg hatching.
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000443250 | 1-1851 | Chitin synthase | |||
Sequence: MQYHQHQHQFPGPGPSHTSVYSSDGFSCSMESIPLPEHLQQRNPPMEEHYLQQTILPTRVPESTVAKAREIVLSHITSQEHLPWDTFRLLPPKADRHQKDTLYNGFLQVLKMITFVALFVTTLGSSILAKLSLLVMAAGLGQAGHNISICPDKIPESPKNSVLISPKNAAKWAWALLLAICIPELLCFARSLHRSLFRKVRGPSFLQFLLVFTVESVHAFGLGALVFAIMPRGMVITMLQLGNSLCLIPSLLLPLSRSRSRWLPLLLLLDGSAILAQSSAAIWRGSIPLERFGFVFLCTSLISIAWWQNFVHPHSFLPATRFFAHYAAKLRECRSKTFVVLSPWKCLIFTFCMFQFVPPQIPFRELLQKDPFGEKLVTINAYNLNQSQLNAFQERMENLERKAFHQQHPHIVHPLKLNRKIVENIANGEAALFRNGTRRPPKKEEVKKNKMDSKKKTKKLKKKKGGNNNATSTNSSEKTPTKGGVLPTKRERRTMAATGSNERVEADYSSNSDADEQEEEEENVAAYNIYDDRVELNQFTTANDALWLVFVQAGSVLLCQLCAKFACKVVMQRVGLALPVVLSIPFGILFLAYSCRQKATNPCHLSEWMSKELFWQCPTRPFHWQRFFREQPNLLWLCWWLSQCWITIHLWLPRQERLAKSEKLFVLGYIDAPFPEHSIALDRRRDDKIQIRSEDIDTEEEANEGGGEQEDGNSSTHTCESAASGLVVVEAPFPKHPNVGRPTAASICSNGSLSSGSHRSDDGGLIRELPSSADSVCKIYVCATMWHESALEMGCMLKSIFRLDKDQCARRNAQRYLKVVDPDYYVFEAHIYIDDAFELDENGNPHPNKFVHQLLEKMDEAASTKLQLRTPRICVTSYGGRISYVLPWRNRLSIHLKNKLLIRQRKRWSQVMYLYFLLGFRLMLRVHEQKRRELLAENTFILTLDGDVDFQPECVHLLVDLMRKNRRLGAACGRIHPRGSGLMVWYQKFEYAVGHWLQKATEHMIGCVLCSPGCFSLFRSSALIDDNVARKYATKSEKPFHYVQYDQGEDRWLCTLLLQRGYRVEYCAASDALTFAPEGFSEFFNQRRRWIPSTMANVIDLLRDYRNVVRVNDSVSIWYIAYQLVMLFSSVLGPGTIFLMIVGAISISFNIDTRLALLIVTTPVLCFCVCCLTCGTETQLLLAQVIGALFAMLMTAVIVGTSLQIQKDGLLSPHSIFLFTVLGSWSFSALLHPLEFGCLLPCGLYFLAIPCMYMLLPVYSLCNLNTVSWGTRENASVSSSSTGQFSGKREERGDILPHLQKTEDGELSVGCGNFCRVVCCVRNPSSPPCADETVEVRKLDENFRKIERKLQSLERRTNGQGNNAEEEGKEEEETGKSEQERKEGREEGKEEEGKMSKRKKEEMDLKGWMELEPFRRFEPIVLDTEEESFWREMIEKYLRPILPNSNEQARIQRGLNELRNTCCSAFFMVNIVFIIVVLVLQLQKDCLHIEWPLGPLVNQTRVQCGGGGGRDFEGEEWIMSRLQLEPMGFVFIVFFLIILFIQFLAMLFHRFGTFTHIIASTELCCAQRPLDKLSEEELVAQNAVEIVRELQAIRGIDSSLSRSEQFQQQPLQRQTRQHFPRTLSLGKRQQNAQIPPRCEKGGNERGEESPTSLPAPPVINWSEVHRNHQRVQPMEGGQQFDPRKDTLDAAFRQRFFALSSSSIAADHHQNNGGHLVDTTGTGHIGAAALPLTLNRRTLRALEQRRNILYQRGDRKRIPALNQQFHSIFPSSSESEGEEGEGGGRGRGREQERDKCLEGKKEKFRQRVEEGPARCHRLEELFGKSRKGGPQKRGKVNGENMKFLGTTNKRAK | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 385 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 435 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 469 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 474 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1274 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1660 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
May require proteolytic cleavage for activation.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: MQYHQHQHQFPGPGPSHTSVY | ||||||
Region | 432-522 | Disordered | ||||
Sequence: LFRNGTRRPPKKEEVKKNKMDSKKKTKKLKKKKGGNNNATSTNSSEKTPTKGGVLPTKRERRTMAATGSNERVEADYSSNSDADEQEEEEE | ||||||
Compositional bias | 436-451 | Basic and acidic residues | ||||
Sequence: GTRRPPKKEEVKKNKM | ||||||
Compositional bias | 466-482 | Polar residues | ||||
Sequence: GNNNATSTNSSEKTPTK | ||||||
Region | 693-718 | Disordered | ||||
Sequence: SEDIDTEEEANEGGGEQEDGNSSTHT | ||||||
Coiled coil | 1329-1383 | |||||
Sequence: CADETVEVRKLDENFRKIERKLQSLERRTNGQGNNAEEEGKEEEETGKSEQERKE | ||||||
Compositional bias | 1350-1365 | Basic and acidic residues | ||||
Sequence: LQSLERRTNGQGNNAE | ||||||
Region | 1350-1402 | Disordered | ||||
Sequence: LQSLERRTNGQGNNAEEEGKEEEETGKSEQERKEGREEGKEEEGKMSKRKKEE | ||||||
Compositional bias | 1374-1402 | Basic and acidic residues | ||||
Sequence: TGKSEQERKEGREEGKEEEGKMSKRKKEE | ||||||
Region | 1626-1658 | Disordered | ||||
Sequence: GKRQQNAQIPPRCEKGGNERGEESPTSLPAPPV | ||||||
Region | 1765-1851 | Disordered | ||||
Sequence: HSIFPSSSESEGEEGEGGGRGRGREQERDKCLEGKKEKFRQRVEEGPARCHRLEELFGKSRKGGPQKRGKVNGENMKFLGTTNKRAK | ||||||
Compositional bias | 1777-1826 | Basic and acidic residues | ||||
Sequence: EEGEGGGRGRGREQERDKCLEGKKEKFRQRVEEGPARCHRLEELFGKSRK |
Sequence similarities
Belongs to the chitin synthase family. Class IV subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,851
- Mass (Da)210,667
- Last updated2002-06-01 v1
- Checksum4B63A6DF9505E416
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 436-451 | Basic and acidic residues | ||||
Sequence: GTRRPPKKEEVKKNKM | ||||||
Compositional bias | 466-482 | Polar residues | ||||
Sequence: GNNNATSTNSSEKTPTK | ||||||
Compositional bias | 1350-1365 | Basic and acidic residues | ||||
Sequence: LQSLERRTNGQGNNAE | ||||||
Compositional bias | 1374-1402 | Basic and acidic residues | ||||
Sequence: TGKSEQERKEGREEGKEEEGKMSKRKKEE | ||||||
Compositional bias | 1777-1826 | Basic and acidic residues | ||||
Sequence: EEGEGGGRGRGREQERDKCLEGKKEKFRQRVEEGPARCHRLEELFGKSRK |