Q8SZM7 · Q8SZM7_DROME
- ProteinEpoxide hydrolase
- GeneJheh2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids463 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Catalyzes juvenile hormone hydrolysis.
Catalytic activity
- 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 236 | Nucleophile | ||||
Sequence: D | ||||||
Active site | 382 | Proton donor | ||||
Sequence: Y | ||||||
Active site | 439 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | cis-stilbene-oxide hydrolase activity | |
Molecular Function | epoxide hydrolase activity | |
Biological Process | catabolic process | |
Biological Process | epoxide metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameEpoxide hydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8SZM7
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Microsome membrane ; Single-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 57-170 | Epoxide hydrolase N-terminal | ||||
Sequence: LPFDISVKPEVIEDLIGQLSRPLKAQAPLEGVGFQYGFNANELAKVVKYWRDTYLPKWSEREEYLKKLDHYQTEIQSLKIHFIHAKPSQVKGQKPKKVLPLLLMHGWPGTVREF |
Sequence similarities
Belongs to the peptidase S33 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length463
- Mass (Da)52,036
- Last updated2002-06-01 v1
- ChecksumD453C0C8A69FA8BB