Q8SXL2 · CCHA2_DROME

Function

function

Ligand for the CCHamide-2 receptor CCHa2-R (PubMed:21110953, PubMed:23293632).
In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth (PubMed:26168160).
In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides (PubMed:26020940).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionneuropeptide hormone activity
Biological Processneuropeptide signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuropeptide CCHamide-2

Gene names

    • Name
      CCHa2
    • ORF names
      CG14375

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q8SXL2
  • Secondary accessions
    • Q9VFV7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced food intake in adults and larvae, reduced locomotor activity, delayed development with mutants taking 200 hours to develop from egg to pupa compared to 130 hours for wild-type flies, reduced levels of the insulin-like peptides Ilp2 and Ilp3, and reduced wing size (PubMed:26168160).
Reduced levels of insulin-like peptide Ilp5 and reduced body weight of mid-third instar larvae (PubMed:26020940).

PTM/Processing

Features

Showing features for signal, peptide, disulfide bond, modified residue, propeptide.

TypeIDPosition(s)Description
Signal1-24
PeptidePRO_000043502727-39Neuropeptide CCHamide-2
Disulfide bond28↔35
Modified residue39Histidine amide
PropeptidePRO_000043502843-136

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in endocrine cells of the larval midgut (at protein level) (PubMed:24098432, PubMed:24850274).
Also expressed in endocrine cells of the midgut of adult males and females (at protein level) (PubMed:24098432).
In the midgut, expression occurs mainly in the anterior region (at protein level) (PubMed:24098432).
In the larval central nervous system, expressed in about 40 neurons in the brain hemispheres and ventral nerve cord (at protein level) (PubMed:24098432).
Highly expressed in larval and adult gut with low levels in larval and adult brain (PubMed:24098432).
Very little expression in the larval fat body (PubMed:26168160).
However, another study shows high levels of expression in the larval fat body as well as the larval gut with low levels in the larval central nervous system (PubMed:26020940).

Induction

Repressed in larvae by starvation for 18 hours with levels recovering when larvae are refed with yeast or glucose.

Developmental stage

Very low expression in eggs. Expression increases during the first instar larval stage, decreases gradually during the second and third instar larval stages and in pupae and increases in adults.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region42-78Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    136
  • Mass (Da)
    14,410
  • Last updated
    2002-06-01 v1
  • Checksum
    C6EA5FC76303EF8F
MKSTISLLLVVICTVVLAAQQSQAKKGCQAYGHVCYGGHGKRSLSPGSGSGTGVGGGMGEAASGGQEPDYVRPNGLLPMMAPNEQVPLEGDFNDYPARQVLYKIMKSWFNRPRRPASRLGELDYPLANSAELNGVN

Mass Spectrometry

Molecular mass is 1,347.69 Da. Determined by MALDI.
Molecular mass is 1,348.53 Da. Determined by MALDI.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
AAF54942.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37307.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37308.1
EMBL· GenBank· DDBJ
Genomic DNA
AY089576
EMBL· GenBank· DDBJ
AAL90314.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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