Q8SXL2 · CCHA2_DROME
- ProteinNeuropeptide CCHamide-2
- GeneCCHa2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids136 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ligand for the CCHamide-2 receptor CCHa2-R (PubMed:21110953, PubMed:23293632).
In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth (PubMed:26168160).
In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides (PubMed:26020940).
In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth (PubMed:26168160).
In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides (PubMed:26020940).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | neuropeptide hormone activity | |
Biological Process | neuropeptide signaling pathway |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNeuropeptide CCHamide-2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8SXL2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced food intake in adults and larvae, reduced locomotor activity, delayed development with mutants taking 200 hours to develop from egg to pupa compared to 130 hours for wild-type flies, reduced levels of the insulin-like peptides Ilp2 and Ilp3, and reduced wing size (PubMed:26168160).
Reduced levels of insulin-like peptide Ilp5 and reduced body weight of mid-third instar larvae (PubMed:26020940).
Reduced levels of insulin-like peptide Ilp5 and reduced body weight of mid-third instar larvae (PubMed:26020940).
PTM/Processing
Features
Showing features for signal, peptide, disulfide bond, modified residue, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MKSTISLLLVVICTVVLAAQQSQA | ||||||
Peptide | PRO_0000435027 | 27-39 | Neuropeptide CCHamide-2 | |||
Sequence: GCQAYGHVCYGGH | ||||||
Disulfide bond | 28↔35 | |||||
Sequence: CQAYGHVC | ||||||
Modified residue | 39 | Histidine amide | ||||
Sequence: H | ||||||
Propeptide | PRO_0000435028 | 43-136 | ||||
Sequence: SLSPGSGSGTGVGGGMGEAASGGQEPDYVRPNGLLPMMAPNEQVPLEGDFNDYPARQVLYKIMKSWFNRPRRPASRLGELDYPLANSAELNGVN |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Expressed in endocrine cells of the larval midgut (at protein level) (PubMed:24098432, PubMed:24850274).
Also expressed in endocrine cells of the midgut of adult males and females (at protein level) (PubMed:24098432).
In the midgut, expression occurs mainly in the anterior region (at protein level) (PubMed:24098432).
In the larval central nervous system, expressed in about 40 neurons in the brain hemispheres and ventral nerve cord (at protein level) (PubMed:24098432).
Highly expressed in larval and adult gut with low levels in larval and adult brain (PubMed:24098432).
Very little expression in the larval fat body (PubMed:26168160).
However, another study shows high levels of expression in the larval fat body as well as the larval gut with low levels in the larval central nervous system (PubMed:26020940).
Also expressed in endocrine cells of the midgut of adult males and females (at protein level) (PubMed:24098432).
In the midgut, expression occurs mainly in the anterior region (at protein level) (PubMed:24098432).
In the larval central nervous system, expressed in about 40 neurons in the brain hemispheres and ventral nerve cord (at protein level) (PubMed:24098432).
Highly expressed in larval and adult gut with low levels in larval and adult brain (PubMed:24098432).
Very little expression in the larval fat body (PubMed:26168160).
However, another study shows high levels of expression in the larval fat body as well as the larval gut with low levels in the larval central nervous system (PubMed:26020940).
Induction
Repressed in larvae by starvation for 18 hours with levels recovering when larvae are refed with yeast or glucose.
Developmental stage
Very low expression in eggs. Expression increases during the first instar larval stage, decreases gradually during the second and third instar larval stages and in pupae and increases in adults.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length136
- Mass (Da)14,410
- Last updated2002-06-01 v1
- ChecksumC6EA5FC76303EF8F
Mass Spectrometry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF54942.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ADV37307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ADV37308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY089576 EMBL· GenBank· DDBJ | AAL90314.1 EMBL· GenBank· DDBJ | mRNA |