Q8SXB0 · Q8SXB0_DROME

  • Protein
    ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B
  • Gene
    AdamTS-A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

116882004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site458Ca2+ 2 (UniProtKB | ChEBI)
Binding site458Ca2+ 1 (UniProtKB | ChEBI)
Binding site538Ca2+ 1 (UniProtKB | ChEBI)
Binding site590Zn2+ (UniProtKB | ChEBI); catalytic
Active site591
Binding site594Zn2+ (UniProtKB | ChEBI); catalytic
Binding site600Zn2+ (UniProtKB | ChEBI); catalytic
Binding site654Ca2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Cellular Componentmembrane
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processepithelial cell migration, open tracheal system
Biological Processextracellular matrix organization
Biological Processgerm cell migration
Biological Processlarval salivary gland morphogenesis
Biological Processmesodermal cell migration
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B
      (EC:3.4.24.-
      )
    • GH16393p

Gene names

    • Name
      AdamTS-A
    • Synonyms
      ADAMTS-A
      , CT19033
      , Dmel\CG14869
      , l(3)89Aa
      , rnwy
    • ORF names
      CG14869
      , CG6107
      , Dmel_CG14869

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q8SXB0
  • Secondary accessions
    • Q9VF61

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane160-181Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond527↔574
Disulfide bond549↔557
Disulfide bond569↔654
Disulfide bond606↔638
Disulfide bond681↔703
Disulfide bond692↔714
Disulfide bond698↔734
Disulfide bond727↔739
Disulfide bond763↔800
Disulfide bond767↔805
Disulfide bond778↔790

Keywords

Proteomic databases

Expression

Gene expression databases

    • FBgn0286071Expressed in nurse follicle cell (Drosophila) in ovary and 93 other cell types or tissues

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias188-202Polar residues
Region188-231Disordered
Domain455-659Peptidase M12B
Region1449-1496Disordered
Compositional bias1461-1490Polar residues
Domain1492-1688GON

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,688
  • Mass (Da)
    189,868
  • Last updated
    2002-06-01 v1
  • Checksum
    48FB8DD4DE0CA4D2
MSMPDAGSLKSPAGGQEVECHRLLSDLPAFAYPSTTLRSTTSGHSTGTNSTTVCESPGARDRTSFACSSSCVSSACSATASDDDEDERALERCLRGTTDDLGESGLRYSLKGPPPELYSAKKDFISKGPLLGRQLEVKKRCEWWCHKYIQKMSTHWRQNACLYACCIAFLLGMLIMFHLGLRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQTHSSNEMLKHFCQFINQSGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCSSSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQCNCEGVEKRRDFCFNSHKGRIACPTRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYYEYRTKQTNSCPPESRGHEYYNDQNSGRTHFRKLRLNITDLRIMDNDFKFADSRGLAQKLGSAGDCYNRIGQCPQGDFSINMKDTDFSIRPGTVWRMHGQYSVMKRISEFDTTTQMRRGFCGGYCGGCYIAPDSGLYLDVL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0B4KHK4A0A0B4KHK4_DROMEAdamTS-A1585
Q7KSH7Q7KSH7_DROMEAdamTS-A1537

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias188-202Polar residues
Compositional bias1461-1490Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY094716
EMBL· GenBank· DDBJ
AAM11069.1
EMBL· GenBank· DDBJ
mRNA
AE014297
EMBL· GenBank· DDBJ
AAS65157.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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