Q8SXB0 · Q8SXB0_DROME
- ProteinADAM metallopeptidase with thrombospondin type 1 motif A, isoform B
- GeneAdamTS-A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1688 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 458 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 458 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 538 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 590 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 591 | |||||
Sequence: E | ||||||
Binding site | 594 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 600 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 654 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Cellular Component | membrane | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | epithelial cell migration, open tracheal system | |
Biological Process | extracellular matrix organization | |
Biological Process | germ cell migration | |
Biological Process | larval salivary gland morphogenesis | |
Biological Process | mesodermal cell migration | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8SXB0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 160-181 | Helical | ||||
Sequence: ACLYACCIAFLLGMLIMFHLGL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 527↔574 | |||||
Sequence: CQFINQSGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCSSSSC | ||||||
Disulfide bond | 549↔557 | |||||
Sequence: CGSVPGKIC | ||||||
Disulfide bond | 569↔654 | |||||
Sequence: CSSSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSC | ||||||
Disulfide bond | 606↔638 | |||||
Sequence: CMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKC | ||||||
Disulfide bond | 681↔703 | |||||
Sequence: CQLSFGNDFGYCPTDEECKRLWC | ||||||
Disulfide bond | 692↔714 | |||||
Sequence: CPTDEECKRLWCNRTSGNSNEQC | ||||||
Disulfide bond | 698↔734 | |||||
Sequence: CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWC | ||||||
Disulfide bond | 727↔739 | |||||
Sequence: CGSSGHWCQRGKC | ||||||
Disulfide bond | 763↔800 | |||||
Sequence: CSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSC | ||||||
Disulfide bond | 767↔805 | |||||
Sequence: CGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQC | ||||||
Disulfide bond | 778↔790 | |||||
Sequence: CNQPVPENGGKYC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 188-202 | Polar residues | ||||
Sequence: QEELPQSTHPLANSP | ||||||
Region | 188-231 | Disordered | ||||
Sequence: QEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDL | ||||||
Domain | 455-659 | Peptidase M12B | ||||
Sequence: YTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQTHSSNEMLKHFCQFINQSGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCSSSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSV | ||||||
Region | 1449-1496 | Disordered | ||||
Sequence: SCTPPPHCRRRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRSC | ||||||
Compositional bias | 1461-1490 | Polar residues | ||||
Sequence: AIGSSISSRPRGTGVSSSRSLNSIGGSRNR | ||||||
Domain | 1492-1688 | GON | ||||
Sequence: TPRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYYEYRTKQTNSCPPESRGHEYYNDQNSGRTHFRKLRLNITDLRIMDNDFKFADSRGLAQKLGSAGDCYNRIGQCPQGDFSINMKDTDFSIRPGTVWRMHGQYSVMKRISEFDTTTQMRRGFCGGYCGGCYIAPDSGLYLDVL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,688
- Mass (Da)189,868
- Last updated2002-06-01 v1
- Checksum48FB8DD4DE0CA4D2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4KHK4 | A0A0B4KHK4_DROME | AdamTS-A | 1585 | ||
Q7KSH7 | Q7KSH7_DROME | AdamTS-A | 1537 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 188-202 | Polar residues | ||||
Sequence: QEELPQSTHPLANSP | ||||||
Compositional bias | 1461-1490 | Polar residues | ||||
Sequence: AIGSSISSRPRGTGVSSSRSLNSIGGSRNR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY094716 EMBL· GenBank· DDBJ | AAM11069.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | AAS65157.1 EMBL· GenBank· DDBJ | Genomic DNA |