Q8SVN8 · NTE1_ENCCU

Function

function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).

Catalytic activity

Activity regulation

Inhibited by organophosphorus esters.

Features

Showing features for binding site, active site.

1905100200300400500600700800900
TypeIDPosition(s)Description
Binding site198-319a nucleoside 3',5'-cyclic phosphate 1 (UniProtKB | ChEBI)
Binding site310-428a nucleoside 3',5'-cyclic phosphate 2 (UniProtKB | ChEBI)
Active site643Nucleophile
Active site761Proton acceptor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionlysophospholipase activity
Biological Processlipid catabolic process
Biological Processphosphatidylcholine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysophospholipase NTE1
  • EC number
  • Alternative names
    • Intracellular phospholipase B
    • Neuropathy target esterase homolog

Gene names

    • Name
      NTE1
    • Ordered locus names
      ECU05_0070

Organism names

Accessions

  • Primary accession
    Q8SVN8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane, topological domain.

TypeIDPosition(s)Description
Transmembrane1-21Helical
Topological domain22-905Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002953211-905Lysophospholipase NTE1

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain610-774PNPLA
Motif614-619GXGXXG
Motif641-645GXSXG
Motif761-763DGA/G

Sequence similarities

Belongs to the NTE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    905
  • Mass (Da)
    103,088
  • Last updated
    2002-06-01 v1
  • Checksum
    94B9D7775EA8E92C
MVSLSLLIAIIVVTGLLAGFRHYGSSRCRTVPFKIKSRSIEKTASTRLLGMSLEDAMKRYPLFNFYPGQSIREILSSWERVTYGNGETIAAPGFILQGLVEIWYREHLVCVKEKGSFLNGSMELLGYSTRGTKKARGSVEVLLIDASLVRDNIWYILFSMLRKSCIEIACRYFELESKLVEKETMKIKDDGQGHLDLFLSFLNEKLLLNLDDGKEILRRDIEARLIGRGETIKDSEESMDYIMYVVSGEILVLAGESAFVFGKGSVFGYFSLFFDLYSSIKIQAREDSSVLLCSSSVLLKFGLDEKKFDHSMLLDIDESLHIIDESAEWMRLLPGDMIAQKGDASKEIFYIGAGSVKSASRESSSGTVIGGKECIFGESWNESSIATRITDVVRIPSLLVDYFLERDKSFFKKYTKRLFESGNKANGKIVSIIPVGQYKDIESFSRKLKSAIGASSLLLSRRDVVEILARRAFDTTEEVRFMDYLTKMSRRYEIILIYVENEYSRLLRYLLNFSDVLLAVGTTFADIPEYNVYCRIEFVKIYEERRASDERSVKKSKKINHGPRYLESRKESFGQYDRVHHVLFPSKTMLFCSKDFQRLARSLLGKRIGLVLGGGGARGLAHIGVIQALEEEGIPIDCVGGTSMGAFIGALYAKECNNYHVFKQAKRFSRKMSNIWILLLDLTYPICSMFSGHAFNRSLHSIFGDGLIQDLWLEYFCITTNIVSYEEEVHRNGMVWRYVRASMGLCGYLPPICDNKKLLVDGGYLNNVPADVMMGMQVEKIITVDVGTVLENDHFDYGDTLSGFTILFNKFFGNKKFVTMEEIQYRLAYISTERKMKELEANGNIIMLRPDLGKYRTMDFKKFDEIVACGYQSTKNAIAKWKQEGTYDVLFFSLKKQTPKRRYSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL590445
EMBL· GenBank· DDBJ
CAD26524.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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