Q8STE5 · CED12_CAEEL
- ProteinCell death abnormality protein 12
- Geneced-12
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids731 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration (PubMed:11146658, PubMed:11595183, PubMed:11703939, PubMed:11703940, PubMed:14645848, PubMed:15247908, PubMed:15620647, PubMed:15744306, PubMed:21490059).
Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body (PubMed:26292279).
Plays no role in amphid axon outgrowth (PubMed:12297102).
Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body (PubMed:26292279).
Plays no role in amphid axon outgrowth (PubMed:12297102).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCell death abnormality protein 12
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ8STE5
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Deformity in the gonadal arm (PubMed:11703940).
Defective distal tip cell migration (PubMed:11703939, PubMed:11703940, PubMed:15247908, PubMed:26292279).
Defective cell corpse engulfment with an increased number of cell corpses (PubMed:11146658, PubMed:11703939, PubMed:11703940, PubMed:15620647).
Absent actin 'halos' around early apoptotic corpses, which is likely indicative of defective actin reorganization around the apoptotic cell (PubMed:15744306).
Double knockout in an unc-5 or unc-40 mutant background suppresses the distal tip cell migratory defect in the respective single mutants (PubMed:26292279).
Defective distal tip cell migration (PubMed:11703939, PubMed:11703940, PubMed:15247908, PubMed:26292279).
Defective cell corpse engulfment with an increased number of cell corpses (PubMed:11146658, PubMed:11703939, PubMed:11703940, PubMed:15620647).
Absent actin 'halos' around early apoptotic corpses, which is likely indicative of defective actin reorganization around the apoptotic cell (PubMed:15744306).
Double knockout in an unc-5 or unc-40 mutant background suppresses the distal tip cell migratory defect in the respective single mutants (PubMed:26292279).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000379436 | 1-731 | Cell death abnormality protein 12 | |||
Sequence: MAFHMPLKELQPVDTSLPEHVVKGAVVIDKEFTIWNHRAVIPSNALHTVFITINLLEQKLTDVVKMAARSMNLSEDDSYGLMADKPKRFITDDNLNSLGSGFILTLCASPDHYVKRITEILTEGNNISQMENAVKTLDEFSLDPALIEAFYRCSSLELLFSLIRDDRVCMSSTLLSTCLRALSSMLELAVGDFTWKSVPNDVVVSMASLVTGKAKREEANTLLAALQMLEQLVIGDDTTRDWILEEVPIETLIRHVEKSDERIALCALSLMNSMIRRCPDDEKRFELIKSLEVVPFRNAVHSSLLRGGGGVRNLNAIEQLVEVQRSLISAYETSPPTDAEVQKILDIESSEDVSEEIREMWKSQIGEHRCGRLAAISMVQFAEKSPQDLRMLISENTMRIEGGKWQLIPMWMRCCDIAAELFRVIPGRDELDRLIVVLFSTETPFPAVFACIVHLFHRTWREMQAKGGEMEKVACVVLEQLRHVLKRREIQDVEELSADLETFSYRAMQEIWREEQLGKENIQLHSEAVIQLKSKLRPKMEELVRINHLNYLKLGAVFRKPQKSKSLAKLAFWHWKLDASEKMLTITGCDGENYVEGVQRDDIRQVWIKDIADVTNNDEIDRKASSSRFTSSPSTQMLRGIRVQLKTTNDMKEGEVLMALTSDETQSVIWLEGLAELIGSKAVKSETDAMVERMLKMELRVRLLNVKLTNPEEKPEIPPIPDDIKSFISKF |
Proteomic databases
Expression
Interaction
Subunit
Interacts with psr-1. Forms a ternary complex with ced-2 and ced-5.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8STE5 | ced-5 G5EEN3 | 4 | EBI-6390460, EBI-6390483 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 339-485 | ELMO | ||||
Sequence: AEVQKILDIESSEDVSEEIREMWKSQIGEHRCGRLAAISMVQFAEKSPQDLRMLISENTMRIEGGKWQLIPMWMRCCDIAAELFRVIPGRDELDRLIVVLFSTETPFPAVFACIVHLFHRTWREMQAKGGEMEKVACVVLEQLRHVL | ||||||
Domain | 544-679 | PH | ||||
Sequence: VRINHLNYLKLGAVFRKPQKSKSLAKLAFWHWKLDASEKMLTITGCDGENYVEGVQRDDIRQVWIKDIADVTNNDEIDRKASSSRFTSSPSTQMLRGIRVQLKTTNDMKEGEVLMALTSDETQSVIWLEGLAELIG | ||||||
Motif | 715-718 | SH3-binding | ||||
Sequence: PEIP |
Domain
The PH domain binds phosphatidylinositol 3,5-biphosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol 3,4,5-trisphosphate in vitro (PubMed:21490059).
Required for punctate localization in the cytoplasm and cell corpse engulfment (PubMed:11703939).
Required for distal cell tip migration (PubMed:15247908).
Required for punctate localization in the cytoplasm and cell corpse engulfment (PubMed:11703939).
Required for distal cell tip migration (PubMed:15247908).
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length731
- Mass (Da)83,148
- Last updated2002-06-01 v1
- Checksum5243F167AE0C868B
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
V5Z1T2 | V5Z1T2_CAEEL | ced-12 | 738 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF416781 EMBL· GenBank· DDBJ | AAL38510.1 EMBL· GenBank· DDBJ | mRNA | ||
AF324505 EMBL· GenBank· DDBJ | AAL49495.1 EMBL· GenBank· DDBJ | mRNA | ||
AL032656 EMBL· GenBank· DDBJ | CAD12890.1 EMBL· GenBank· DDBJ | Genomic DNA |