Q8STE5 · CED12_CAEEL

  • Protein
    Cell death abnormality protein 12
  • Gene
    ced-12
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration (PubMed:11146658, PubMed:11595183, PubMed:11703939, PubMed:11703940, PubMed:14645848, PubMed:15247908, PubMed:15620647, PubMed:15744306, PubMed:21490059).
Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body (PubMed:26292279).
Plays no role in amphid axon outgrowth (PubMed:12297102).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentguanyl-nucleotide exchange factor complex
Cellular Componentplasma membrane
Molecular Functionenzyme binding
Molecular Functionphosphatidylinositol-3,4,5-trisphosphate binding
Molecular Functionphosphatidylinositol-3,5-bisphosphate binding
Molecular Functionphosphatidylinositol-4-phosphate binding
Molecular Functionproline-rich region binding
Molecular Functionprotein-containing complex binding
Molecular FunctionSH3 domain binding
Molecular Functionsmall GTPase binding
Biological Processactin cytoskeleton organization
Biological Processactin filament organization
Biological Processapoptotic process involved in development
Biological Processcell migration
Biological Processcell motility
Biological Processcytoskeletal rearrangement involved in phagocytosis, engulfment
Biological Processengulfment of apoptotic cell
Biological Processestablishment of mitotic spindle orientation
Biological Processgonad morphogenesis
Biological Processleft/right axis specification
Biological Processphagocytosis, engulfment
Biological Processpositive regulation of distal tip cell migration
Biological Processpositive regulation of engulfment of apoptotic cell
Biological Processregulation of cell migration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cell death abnormality protein 12

Gene names

    • Name
      ced-12
    • ORF names
      Y106G6E.5

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q8STE5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Deformity in the gonadal arm (PubMed:11703940).
Defective distal tip cell migration (PubMed:11703939, PubMed:11703940, PubMed:15247908, PubMed:26292279).
Defective cell corpse engulfment with an increased number of cell corpses (PubMed:11146658, PubMed:11703939, PubMed:11703940, PubMed:15620647).
Absent actin 'halos' around early apoptotic corpses, which is likely indicative of defective actin reorganization around the apoptotic cell (PubMed:15744306).
Double knockout in an unc-5 or unc-40 mutant background suppresses the distal tip cell migratory defect in the respective single mutants (PubMed:26292279).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003794361-731Cell death abnormality protein 12

Proteomic databases

Expression

Developmental stage

Expressed in developing embryos.

Gene expression databases

Interaction

Subunit

Interacts with psr-1. Forms a ternary complex with ced-2 and ced-5.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8STE5ced-5 G5EEN34EBI-6390460, EBI-6390483

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain339-485ELMO
Domain544-679PH
Motif715-718SH3-binding

Domain

The PH domain binds phosphatidylinositol 3,5-biphosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol 3,4,5-trisphosphate in vitro (PubMed:21490059).
Required for punctate localization in the cytoplasm and cell corpse engulfment (PubMed:11703939).
Required for distal cell tip migration (PubMed:15247908).

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    731
  • Mass (Da)
    83,148
  • Last updated
    2002-06-01 v1
  • Checksum
    5243F167AE0C868B
MAFHMPLKELQPVDTSLPEHVVKGAVVIDKEFTIWNHRAVIPSNALHTVFITINLLEQKLTDVVKMAARSMNLSEDDSYGLMADKPKRFITDDNLNSLGSGFILTLCASPDHYVKRITEILTEGNNISQMENAVKTLDEFSLDPALIEAFYRCSSLELLFSLIRDDRVCMSSTLLSTCLRALSSMLELAVGDFTWKSVPNDVVVSMASLVTGKAKREEANTLLAALQMLEQLVIGDDTTRDWILEEVPIETLIRHVEKSDERIALCALSLMNSMIRRCPDDEKRFELIKSLEVVPFRNAVHSSLLRGGGGVRNLNAIEQLVEVQRSLISAYETSPPTDAEVQKILDIESSEDVSEEIREMWKSQIGEHRCGRLAAISMVQFAEKSPQDLRMLISENTMRIEGGKWQLIPMWMRCCDIAAELFRVIPGRDELDRLIVVLFSTETPFPAVFACIVHLFHRTWREMQAKGGEMEKVACVVLEQLRHVLKRREIQDVEELSADLETFSYRAMQEIWREEQLGKENIQLHSEAVIQLKSKLRPKMEELVRINHLNYLKLGAVFRKPQKSKSLAKLAFWHWKLDASEKMLTITGCDGENYVEGVQRDDIRQVWIKDIADVTNNDEIDRKASSSRFTSSPSTQMLRGIRVQLKTTNDMKEGEVLMALTSDETQSVIWLEGLAELIGSKAVKSETDAMVERMLKMELRVRLLNVKLTNPEEKPEIPPIPDDIKSFISKF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
V5Z1T2V5Z1T2_CAEELced-12738

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF416781
EMBL· GenBank· DDBJ
AAL38510.1
EMBL· GenBank· DDBJ
mRNA
AF324505
EMBL· GenBank· DDBJ
AAL49495.1
EMBL· GenBank· DDBJ
mRNA
AL032656
EMBL· GenBank· DDBJ
CAD12890.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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