Q8ST66 · ABCGI_DICDI

Function

function

Required for endocytosis and endosomal pH regulation.

Features

Showing features for binding site.

114762004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site105-112ATP 1 (UniProtKB | ChEBI)
Binding site848-855ATP 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processaggregation involved in sorocarp development
Biological Processcell differentiation
Biological Processendocytosis
Biological Processendosomal lumen acidification
Biological Processsorocarp morphogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ABC transporter G family member 18
  • Alternative names
    • ABC transporter ABCG.18
    • ABC transporter mdrA2

Gene names

    • Name
      abcG18
    • Synonyms
      mdra2
    • ORF names
      DDB_G0275687

Organism names

Accessions

  • Primary accession
    Q8ST66
  • Secondary accessions
    • Q553B8
    • Q8MXM5
    • Q965D3

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane455-475Helical
Transmembrane485-505Helical
Transmembrane523-543Helical
Transmembrane561-581Helical
Transmembrane590-610Helical
Transmembrane618-638Helical
Transmembrane698-718Helical
Transmembrane1211-1228Helical
Transmembrane1239-1259Helical
Transmembrane1290-1310Helical
Transmembrane1324-1344Helical
Transmembrane1349-1369Helical
Transmembrane1448-1468Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Cells that have a abcG2-abcG18 disruption have an endocytosis rate roughly 70% that of wild-type (or rtoA disrupted cells). Disruption on abcG2-abcG18-rtoA cells have an endocytosis rate roughly 20% that of wild-type. The exocytosis rates of abcG2-abcG18 and abcG2-abcG18-rtoA disrupted cells are roughly that of wild-type; abcG2-abcG18 endosomes have an unusually high pH, whereas abcG2-abcG18-rtoA endosomes have an almost normal pH.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003303661-1476ABC transporter G family member 18

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain69-312ABC transporter 1
Domain445-722ABC transmembrane type-2 1
Compositional bias743-768Polar residues
Region743-786Disordered
Compositional bias769-786Basic and acidic residues
Domain814-1053ABC transporter 2
Region1081-1141Disordered
Domain1201-1471ABC transmembrane type-2 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,476
  • Mass (Da)
    166,508
  • Last updated
    2002-06-01 v1
  • Checksum
    D729985CE02821A7
MENEEKREYLAKSRSNSRNFLNDSIESKNIFGVDKKSEPNLKQSIDGGLNFSTTSSYNPSNLPRTSVFVSARNLSSTVGHGKNEKKILTDLNFFLKPGSMVLLLGSPGCGKTSLMNTLALLTSNEKITGNLLFNGKTGDPNTHHRHVSYVVQDDFHMAPLTVRDTFKFSADCQSGDKSEKERIEIVDNVLDFLDLKHVQNTVVGDEFLRGISGGQKKRVTIGVELVKESNLLLMDEPTNGLDSSISLEMLTKIKNKVQQEKMSCLISLLQPGLEITKLFDYLMIMNQGQMSYFGPMNQAIGYFEGLGFKFPKHHNPAEFFQEIVDEPELYCGIDDGSSDGGSGDSGSSSGGSNYNYNFKNKASSTMMMMNNNNKIIPPLKGSDEFAMAYRKSIIYKHILEYIDSHIPDEEERSKFIDYSTTLKPYSTGFGRQLSLNVKRGFKLFLGNKASIRLRLLKNVIIGFILGTLYWKLDTTQADGSNRSGLLFFSLLTFVFGGFGSISVFFDQRQVFYSERAWKYYNTITYFLSMIVTDLPMSIVEVLIFSNFVYWMTGLNKTWDRFIYFFLTCLVCDVMSLSIIRSVCSFTKTKYAASAISPAVVSPFILMCGYMKHSNEIPGWWIWLYWISPIHYGFEGLLLNEHSGLDYHCSPDELMPPSFLPTFNTSYPVGFEGNQVCPITKGEQILDSIGFHTEFYYRWVDLAIISAFTLLFWLITLVCMKFLVFRVYRKDPVGIKKSKPNKTTTLIKMNRNSTDSTTTNNSMNYFNNKHNKKQNDDSDSGEEMESVDVDVKSSGKANLRKDIPIGCYMQWKDLVYEVDVKKDGKNQRLRLLNGINGYVKPGMLVALMGPSGAGKSTLLDVLANRKTGGHTKGQILINGQERTKYFTRTSAYVEQMDILTPVSTVREVILFSAKNRLPNSVPIQEKEEFVDNILETLNLLKIQHSLIGDVESGLSLSQRKRVNMGIELASDPQLLFLDEPTSGLDSSAALKVMNLIKKIASSGRSVICTIHQPSTTIFKKFDHLLLLKRGGETVYFGPTGTNSKIVLNYFAERGLICDPFKNPADFILDVTEDIIEIIQPPQTLPTSTSNENNNNNNNNNNNNNNNNNNNNNNNNNNNNGNTSDTLNNNNKKNLESSLSSSSISFDPVESFKESKENQKLLSIVENSIMPVGTPVAVYHGKYSSTIKTQFIELLKRSWKGGIRRVDTIRTRVGRSFVLGLVIGTLFLRLDKEQNDVFNRISFLFFSLMFGGMAGLSIIPTVSTERGVFYREQASGMYRVWIYYLTFVLSDLPFVIITSYAYVIPVYFLTGLSLSNHGWDFFYHSFISVMLYLNFGLTSIAFATSLPVEEMAFLLNGVLLSVTSLFAGFMIPPPSMPAAWKWAFYLDFISYPLKAFLITEFKDMEFVCTDNKGAIPIPIPSQNTTKFFCPITHGTQVLDRIDYKISFQYWDILIMASFTFALLVGGYLSLKFIRYQNK

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict18in Ref. 1; AAK69777
Compositional bias743-768Polar residues
Compositional bias769-786Basic and acidic residues
Sequence conflict1122in Ref. 1; AAK69777
Sequence conflict1350in Ref. 1; AAK69777

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF246689
EMBL· GenBank· DDBJ
AAK69777.1
EMBL· GenBank· DDBJ
Genomic DNA
AF482381
EMBL· GenBank· DDBJ
AAL91487.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000013
EMBL· GenBank· DDBJ
EAL69594.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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