Q8SQP0 · KPYK_ENCCU
- ProteinPyruvate kinase
- GenePYK1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids428 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- ATP + pyruvate = ADP + H+ + phosphoenolpyruvate
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 34 | substrate | ||||
Sequence: R | ||||||
Binding site | 36 | K+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 36-39 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NFSH | ||||||
Binding site | 38 | K+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 68 | K+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 69 | K+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 75 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 152 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Site | 212 | Transition state stabilizer | ||||
Sequence: K | ||||||
Binding site | 214 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 237 | substrate | ||||
Sequence: G | ||||||
Binding site | 238 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 238 | substrate | ||||
Sequence: D | ||||||
Binding site | 270 | substrate | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | potassium ion binding | |
Molecular Function | pyruvate kinase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate kinase
- EC number
- Short namesPK
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Microsporidia > Unikaryonidae > Encephalitozoon
Accessions
- Primary accessionQ8SQP0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000379473 | 1-428 | Pyruvate kinase | |||
Sequence: MRMVLTKIVCTIGPRTSSREKIKELIDAGMSIARLNFSHGSREAHLEVIRNIRDSRSGAGRHVSIALDTRGPEVRLRTPEMKDIKVEGGEVLRFSLLSSEKDIWIPGVDLKSLGVDNRVFIDDGAIELRVVNVEEDGFECEVLNSGMIKSNKSMNFPGTDIGDRALGDEDKNDIAFGLENGIDMVFASFVSCRADVEEIRRLVGSKVPVVSKIESCLGMRNLKEIALCSDGVMIARGDLGVEIGLENMFSAQKRILYEVKREGRPVICATQMMESMTLKNAPNRSEISDVGNAVLDGCDCVMLSAESAVGMFPVETVKFMRSICADAERYDMESRKGAGACGVSSYVDGVVICSGTESQIEKIYLSKPETPIIVISESLWILRRFSIYRGIIPVYGKGSEDAEATLRRLGLRGRFLAVGREDVRMVSV |
Expression
Developmental stage
Expressed in late sporogonial stages.
Interaction
Structure
Sequence
- Sequence statusComplete
- Length428
- Mass (Da)47,063
- Last updated2013-05-29 v2
- Checksum7594602E9E920AC5
Keywords
- Technical term