Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q8SQB9 · Q8SQB9_BOVIN

  • Protein
    Integrin beta
  • Gene
    ITGB5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentfocal adhesion
Cellular Componentintegrin alphav-beta5 complex
Cellular Componentintegrin complex
Molecular Functionintegrin binding
Molecular Functionmetal ion binding
Biological Processcell migration
Biological Processcell-cell adhesion
Biological Processcell-matrix adhesion
Biological Processendodermal cell differentiation
Biological Processepithelial cell-cell adhesion
Biological Processintegrin-mediated signaling pathway
Biological Processstress fiber assembly
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Integrin beta

Gene names

    • Name
      ITGB5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q8SQB9
  • Secondary accessions
    • F1MK32

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane721-743Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_504280927425-800Integrin beta
Disulfide bond36↔46
Disulfide bond39↔75
Disulfide bond49↔64
Disulfide bond202↔211
Disulfide bond259↔300
Disulfide bond401↔413
Disulfide bond433↔683
Disulfide bond461↔465
Disulfide bond484↔522
Disulfide bond489↔498
Disulfide bond500↔513
Disulfide bond528↔533
Disulfide bond530↔563
Disulfide bond535↔548
Disulfide bond550↔555
Disulfide bond569↔574
Disulfide bond571↔602
Disulfide bond576↔585
Disulfide bond608↔613
Disulfide bond610↔658
Disulfide bond615↔625
Disulfide bond628↔631
Disulfide bond635↔644
Disulfide bond641↔715
Disulfide bond662↔691

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-76PSI
Domain35-463Integrin beta subunit VWA
Domain137-372VWFA
Domain635-720Integrin beta subunit tail
Domain744-791Integrin beta subunit cytoplasmic

Sequence similarities

Belongs to the integrin beta chain family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    800
  • Mass (Da)
    88,029
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    5B5F9C9402798C6F63D467CF2C4023F1
MPRAPALLFSCLLGLCALVPRLPGLNICTSGSATSCEECLLIHPKCAWCFKEDFGSLRSVTSRCDLKANLIRNGCGVEFESPASSTQVLRSLPLSSKGSSPAGSDVIQLTPQEVTVTLRPGDKTAFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKNISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNILQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSVEARSCPSKHVQHTFTLRPVGFRDSLEVGVTYNCRCGCSAGLEPDSARCSSNGTYVCGLCECNPGYLGTRCECQEGESQSGYQNLCREAEGKPLCSGRGQCSCNQCSCFESEFGKIYGSFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCQARDGHICSDRGHCVCGQCQCTEPGAFGETCEKCPTCPDACSTKRDCVECLLLHSGSSADNQTCQNLCKDEVITRVDTIVKDDQEAVLCFYKTAKDCVMMFTYSELPSGKSNLTVLREPECGTAPSAMTILLAVVGSILLTGFALLVIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTVD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1MEY0A0A3Q1MEY0_BOVINITGB5755

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF468059
EMBL· GenBank· DDBJ
AAL78038.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help