Q8SQ79 · COX8A_GORGO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Cellular Componentrespiratory chain complex IV
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 8A, mitochondrial
  • Alternative names
    • Cytochrome c oxidase polypeptide VIII-liver
    • Cytochrome c oxidase subunit 8-2

Gene names

    • Name
      COX8A
    • Synonyms
      COX8, COX8L

Organism names

Accessions

  • Primary accession
    Q8SQ79

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain26-36Mitochondrial matrix
Transmembrane37-60Helical
Topological domain61-69Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-25Mitochondrion
ChainPRO_000000618526-69Cytochrome c oxidase subunit 8A, mitochondrial

Post-translational modification

In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.

Keywords

Expression

Gene expression databases

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif2-19SIFI-degron

Sequence similarities

Belongs to the cytochrome c oxidase VIII family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    69
  • Mass (Da)
    7,637
  • Last updated
    2002-06-01 v1
  • Checksum
    14736E52AE58E898
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPDEKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB072327
EMBL· GenBank· DDBJ
BAB86878.1
EMBL· GenBank· DDBJ
Genomic DNA
AY254810
EMBL· GenBank· DDBJ
AAP32244.1
EMBL· GenBank· DDBJ
Genomic DNA
AY254809
EMBL· GenBank· DDBJ
AAP32244.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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