Q8SQ28 · SAA3_BOVIN

  • Protein
    Serum amyloid A-3 protein
  • Gene
    SAA3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity).
May have a role in protection of the mammary gland during remodeling and infection (Probable). In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (PubMed:19283521).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthigh-density lipoprotein particle
Biological Processacute-phase response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Serum amyloid A-3 protein

Gene names

    • Name
      SAA3

Organism names

  • Taxonomic identifier
  • Strain
    • Crossbred X Angus
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q8SQ28
  • Secondary accessions
    • A0A023VWT2
    • Q32PB7
    • Q56J78
    • Q9MZT5

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant48in allele SAA3.2
Natural variant64in allele SAA3.2
Natural variant93in allele SAA3.2
Natural variant108in allele SAA3.2

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_501509935419-131Serum amyloid A-3 protein

Expression

Tissue specificity

Expressed in the liver (PubMed:19283521).
Expressed in mammary epithelial cells (PubMed:11048944, PubMed:16837143, PubMed:19283521).
Expressed at high levels in mammary ductal cells and vesicle engorged alveoli, but absent from stromal and connective tissue and leukocytes (PubMed:19283521).
Secreted into colostrum and mastitic milk (at protein level) (PubMed:16837143, PubMed:19283521).
Low expression levels, if any, in normal milk (at protein level) (PubMed:16837143, PubMed:19283521).

Induction

Up-regulated by Gram-negative bacterial lipopolysaccharide (LPS) and the Gram-positive bacterial lipoteichoic acid (LTA) in mammary epithelial cells and to a lesser extent by prolactin/PRL.

Developmental stage

Expressed at a moderate level in late pregnancy, at a low level through lactation, induced early in milk stasis, and expressed at high levels in most mammary epithelial cells during mid to late involution and inflammation/mastitis.

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias94-105Basic and acidic residues
Region94-131Disordered

Sequence similarities

Belongs to the SAA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    131
  • Mass (Da)
    14,724
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    DEC846A27B7B006B3282458592D758A4
MNLSTGIIFCFLILGVSSQRWGTFLKEAGQGAKDMWRAYQDMKEANYRGADKYFHARGNYDAARRGPGGAWAAKVISNARETIQGITDPLFKGMTRDQVREDSKADQFANEWGRSGKDPNHFRPAGLPDKY

Sequence caution

The sequence AAF77630.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias94-105Basic and acidic residues
Sequence conflict129in Ref. 5; AAX57025

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF160867
EMBL· GenBank· DDBJ
AAF77630.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AF335552
EMBL· GenBank· DDBJ
AAM11538.1
EMBL· GenBank· DDBJ
mRNA
AF540564
EMBL· GenBank· DDBJ
AAN17326.1
EMBL· GenBank· DDBJ
mRNA
DQ298246
EMBL· GenBank· DDBJ
ABC00875.1
EMBL· GenBank· DDBJ
Genomic DNA
AY943216
EMBL· GenBank· DDBJ
AAX57025.1
EMBL· GenBank· DDBJ
mRNA
KJ463389
EMBL· GenBank· DDBJ
AHY20046.1
EMBL· GenBank· DDBJ
mRNA
BC108181
EMBL· GenBank· DDBJ
AAI08182.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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