Q8SHX5 · Q8SHX5_TRIJA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q8SHX5

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-30Helical
Transmembrane42-62Helical
Transmembrane69-88Helical
Transmembrane94-115Helical
Transmembrane136-158Helical
Transmembrane178-197Helical
Transmembrane218-238Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-187NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    241
  • Mass (Da)
    26,630
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    AA85BF005A2247E0D2C3AAFC18387570
WLPKAHVEAPIAGSMVLAAILLKLGGYGMMRISPMLFQIQIMHYPFIILALWGMIMTSLICLRQPDLKSLIAYSSVSHMGLVVTATMIQTPSSLTGAMMLMVAHGITSSMLFCLANIMYERTNTRTLTMMQGMQTAVPIMTAFWLLANLTNMAIPPTINLLGEITITAATFNWSPQTLILTGLTTAITAIYSMYMFSSTQQGKMQKDMMTAPAQTREYLVLILHTIPMILLMINPQTITLT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF443229
EMBL· GenBank· DDBJ
AAM09589.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help