Q8SH21 · Q8SH21_9SAUR
- ProteinCytochrome b
- Genecytb
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids369 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 89 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 174 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 188 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 193 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Colubridae > Natricinae > Psammodynastes
Accessions
- Primary accessionQ8SH21
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 22-49 | Helical | ||||
Sequence: WWNFGSMLLTCLGLQITTGFFLAIHYTA | ||||||
Transmembrane | 70-91 | Helical | ||||
Sequence: IMQNLHATGASMFFICIYTHIA | ||||||
Transmembrane | 103-125 | Helical | ||||
Sequence: GVWLSGTTLLIILMATAFFGYVL | ||||||
Transmembrane | 132-158 | Helical | ||||
Sequence: FWAATVITNLLTAIPYLGTSLTTWLWG | ||||||
Transmembrane | 170-192 | Helical | ||||
Sequence: FFALHFILPFTIISVSSIHILLL | ||||||
Transmembrane | 222-242 | Helical | ||||
Sequence: LMLTSLLTTLFIVMSFFPNLF | ||||||
Transmembrane | 316-332 | Helical | ||||
Sequence: IFWTLIVTFMTITWAAT | ||||||
Transmembrane | 338-363 | Helical | ||||
Sequence: PFITISQTTSIMYFLFFIINPVFGWI |
Keywords
- Cellular component
Interaction
Subunit
The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-201 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MSNQHKLLTFNLLPVGTNISTWWNFGSMLLTCLGLQITTGFFLAIHYTANVNLAFSSIIHITRDVPSGWIMQNLHATGASMFFICIYTHIARGLYYGSYLNKGVWLSGTTLLIILMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGTSLTTWLWGGFSINDPTLTRFFALHFILPFTIISVSSIHILLLHNEGSSNPL | ||||||
Domain | 202-369 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GTNSDIDKIPFHPYHSLKDTLMLTSLLTTLFIVMSFFPNLFNDPENFSKANPMVTPQHIKPEWYFLFAYGILRSVPNKLGGTLALIMSIAILTTAPFTHTSIFRPMTFRPITQPIFWTLIVTFMTITWAATKPVEPPFITISQTTSIMYFLFFIINPVFGWIENKITN |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length369
- Mass (Da)41,671
- Last updated2002-06-01 v1
- Checksum5385FE886C111E24