Q8S9K3 · VAR3_ARATH
- ProteinZinc finger protein VAR3, chloroplastic
- GeneVAR3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids758 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Probable component of some protein complex required for chloroplast and palisade cell development (PubMed:15340011).
Involved in C-to-U editing of chloroplastic RNA. Controls a large number of chloroplastic editing sites. Binds the editing recognition trans-factors PCMP-H51/CRR28 and PCMP-H12/OTP82 (PubMed:25768119).
Involved in C-to-U editing of chloroplastic RNA. Controls a large number of chloroplastic editing sites. Binds the editing recognition trans-factors PCMP-H51/CRR28 and PCMP-H12/OTP82 (PubMed:25768119).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | chloroplast stroma | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA binding | |
Biological Process | chloroplast mRNA modification | |
Biological Process | chloroplast organization | |
Biological Process | mRNA processing |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein VAR3, chloroplastic
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8S9K3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes at punctuate loci in chloroplasts.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Defects result in variegated plants that have leaves consisting of normal green and also white or yellow sectors in which chloroplast development is retarded or disrupted (PubMed:15340011, PubMed:25768119).
Mutant plants exhibit severe editing defects in chloroplastic transcripts (PubMed:25768119).
Mutant plants exhibit severe editing defects in chloroplastic transcripts (PubMed:25768119).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 117 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, transit peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000022653 | ?-758 | Zinc finger protein VAR3, chloroplastic | |||
Sequence: MNNSTRLISLFSPHPPPLFLLRGLYISRIANLRRFHRRAFPPSSVASTNLCSFRPLVSLPPLIPTFPIGRFYNHQVRVSAADFVPSYHNQQLPEWTELLQSLSKAGYFSDSGSISGLESEFFPGFPDELLRPALACLALARERPELLEMLSRRDVEVLVENGKPFLFKTGPDSLKRMSLYLRSGLQGIGKLMDMEKASTVDLMRLILSYVVDVASSEESKQHNKEIMESSVRSLLSQIAKMSLRPPESNVHDTMQNQYSDRDGQGVRSFQNNVEMKRGDWICSRCSGMNFARNVKCFQCDEARPKRQLTGSEWECPQCDFYNYGRNVACLRCDCKRPRDSSLNSANSDYSSDPELERRLVENEKKAQRWLSKVAQGGSDANSVDTDEDFPEIMPLRKGVNRYVVSTRKPPLERRLANTENRVATDGNSKRSDDNALGSKTTRSLNEILGSSSSLTSRSDDKNVSSRRFESSQGINTDFVPFVPLPSDMFAKKPKEETQIGLIDNIQVDGFSGGNQNVYQEDKSDANHSGKETDRLEKEDHKSEEPARWFKRVTELHNVSDLESAIPQEISPEKMPMRKGENRFVVSRKKDRSLTSPAYKRPEDSDFVPFVPFPPDYFAKEKQPKESIDTLPAPATENVSQVVQQEPREPSINKSDTVAVKIRNGKSLEGSLVKESDLLDMSEEAKAERWFKRVAEIKNISELSEIPDEDFPSIMPMRKGVNRFVVSKRKTPLERRLTSQRHQRNPHITNSDPTGKGDK | ||||||
Transit peptide | 1-? | Chloroplast |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts in vitro with the chloroplast-located protein CCD4/NCED4 (PubMed:15340011).
Homodimer. Interacts with ORRM1. Interacts with PCMP-H51/CRR28 and PCMP-H12/OTP82 (PubMed:25768119).
Interacts with ORRM6 (PubMed:28213559).
Homodimer. Interacts with ORRM1. Interacts with PCMP-H51/CRR28 and PCMP-H12/OTP82 (PubMed:25768119).
Interacts with ORRM6 (PubMed:28213559).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8S9K3 | CCD4 O49675 | 2 | EBI-632401, EBI-632411 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 122-502 | 3 X approximate repeat | ||||
Sequence: FPGFPDELLRPALACLALARERPELLEMLSRRDVEVLVENGKPFLFKTGPDSLKRMSLYLRSGLQGIGKLMDMEKASTVDLMRLILSYVVDVASSEESKQHNKEIMESSVRSLLSQIAKMSLRPPESNVHDTMQNQYSDRDGQGVRSFQNNVEMKRGDWICSRCSGMNFARNVKCFQCDEARPKRQLTGSEWECPQCDFYNYGRNVACLRCDCKRPRDSSLNSANSDYSSDPELERRLVENEKKAQRWLSKVAQGGSDANSVDTDEDFPEIMPLRKGVNRYVVSTRKPPLERRLANTENRVATDGNSKRSDDNALGSKTTRSLNEILGSSSSLTSRSDDKNVSSRRFESSQGINTDFVPFVPLPSDMFAKKPKEETQIGLI | ||||||
Zinc finger | 276-305 | RanBP2-type 1 | ||||
Sequence: KRGDWICSRCSGMNFARNVKCFQCDEARPK | ||||||
Zinc finger | 308-338 | RanBP2-type 2 | ||||
Sequence: LTGSEWECPQCDFYNYGRNVACLRCDCKRPR | ||||||
Repeat | 368-415 | 1 | ||||
Sequence: RWLSKVAQGGSDANSVDTDEDFPEIMPLRKGVNRYVVSTRKPPLERRL | ||||||
Region | 410-470 | Disordered | ||||
Sequence: PLERRLANTENRVATDGNSKRSDDNALGSKTTRSLNEILGSSSSLTSRSDDKNVSSRRFES | ||||||
Compositional bias | 420-459 | Polar residues | ||||
Sequence: NRVATDGNSKRSDDNALGSKTTRSLNEILGSSSSLTSRSD | ||||||
Region | 512-545 | Disordered | ||||
Sequence: GGNQNVYQEDKSDANHSGKETDRLEKEDHKSEEP | ||||||
Compositional bias | 523-545 | Basic and acidic residues | ||||
Sequence: SDANHSGKETDRLEKEDHKSEEP | ||||||
Repeat | 547-596 | 2 | ||||
Sequence: RWFKRVTELHNVSDLESAIPQEISPEKMPMRKGENRFVVSRKKDRSLTSP | ||||||
Region | 572-606 | Disordered | ||||
Sequence: EKMPMRKGENRFVVSRKKDRSLTSPAYKRPEDSDF | ||||||
Compositional bias | 573-598 | Basic and acidic residues | ||||
Sequence: KMPMRKGENRFVVSRKKDRSLTSPAY | ||||||
Region | 629-654 | Disordered | ||||
Sequence: TLPAPATENVSQVVQQEPREPSINKS | ||||||
Compositional bias | 632-654 | Polar residues | ||||
Sequence: APATENVSQVVQQEPREPSINKS | ||||||
Repeat | 688-736 | 3 | ||||
Sequence: RWFKRVAEIKNISELSEIPDEDFPSIMPMRKGVNRFVVSKRKTPLERRL | ||||||
Region | 727-758 | Disordered | ||||
Sequence: KRKTPLERRLTSQRHQRNPHITNSDPTGKGDK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length758
- Mass (Da)85,945
- Last updated2004-12-21 v2
- Checksum5659AABF750BF8DE
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 29 | in Ref. 1; AAL09834 | ||||
Sequence: I → V | ||||||
Sequence conflict | 52-53 | in Ref. 1; AAL09834 | ||||
Sequence: SF → FS | ||||||
Sequence conflict | 68 | in Ref. 1; AAL09834 | ||||
Sequence: I → L | ||||||
Sequence conflict | 73 | in Ref. 1; AAL09834 | ||||
Sequence: N → T | ||||||
Sequence conflict | 82 | in Ref. 1; AAL09834 | ||||
Sequence: D → E | ||||||
Sequence conflict | 89 | in Ref. 1; AAL09834 | ||||
Sequence: N → H | ||||||
Sequence conflict | 158 | in Ref. 1; AAL09834 | ||||
Sequence: L → M | ||||||
Sequence conflict | 168 | in Ref. 1; AAL09834 | ||||
Sequence: K → R | ||||||
Sequence conflict | 178 | in Ref. 1; AAL09834 | ||||
Sequence: S → G | ||||||
Sequence conflict | 185 | in Ref. 1; AAL09834 | ||||
Sequence: L → V | ||||||
Sequence conflict | 188 | in Ref. 1; AAL09834 | ||||
Sequence: I → L | ||||||
Sequence conflict | 191 | in Ref. 1; AAL09834 | ||||
Sequence: L → M | ||||||
Sequence conflict | 206 | in Ref. 1; AAL09834 | ||||
Sequence: I → L | ||||||
Sequence conflict | 214 | in Ref. 1; AAL09834 | ||||
Sequence: A → T | ||||||
Sequence conflict | 219-224 | in Ref. 1; AAL09834 | ||||
Sequence: SKQHNK → IKHHNQ | ||||||
Sequence conflict | 239 | in Ref. 1; AAL09834 | ||||
Sequence: A → T | ||||||
Sequence conflict | 252 | in Ref. 1; AAL09834 | ||||
Sequence: D → G | ||||||
Sequence conflict | 265 | in Ref. 1; AAL09834 | ||||
Sequence: G → A | ||||||
Sequence conflict | 340 | in Ref. 1; AAL09834 | ||||
Sequence: S → A | ||||||
Sequence conflict | 348 | in Ref. 1; AAL09834 | ||||
Sequence: D → G | ||||||
Sequence conflict | 351 | in Ref. 1; AAL09834 | ||||
Sequence: S → N | ||||||
Sequence conflict | 357 | in Ref. 1; AAL09834 | ||||
Sequence: R → S | ||||||
Sequence conflict | 370 | in Ref. 1; AAL09834 | ||||
Sequence: L → F | ||||||
Sequence conflict | 409 | in Ref. 1; AAL09834 | ||||
Sequence: P → T | ||||||
Compositional bias | 420-459 | Polar residues | ||||
Sequence: NRVATDGNSKRSDDNALGSKTTRSLNEILGSSSSLTSRSD | ||||||
Sequence conflict | 421 | in Ref. 1; AAL09834 | ||||
Sequence: R → S | ||||||
Sequence conflict | 427 | in Ref. 1; AAL09834 | ||||
Sequence: N → S | ||||||
Sequence conflict | 502 | in Ref. 1; AAL09834 | ||||
Sequence: I → T | ||||||
Sequence conflict | 505-510 | in Ref. 1; AAL09834 | ||||
Sequence: IQVDGF → NQIDGV | ||||||
Compositional bias | 523-545 | Basic and acidic residues | ||||
Sequence: SDANHSGKETDRLEKEDHKSEEP | ||||||
Sequence conflict | 546 | in Ref. 1; AAL09834 | ||||
Sequence: A → G | ||||||
Sequence conflict | 565 | in Ref. 1; AAL09834 | ||||
Sequence: I → M | ||||||
Compositional bias | 573-598 | Basic and acidic residues | ||||
Sequence: KMPMRKGENRFVVSRKKDRSLTSPAY | ||||||
Sequence conflict | 579 | in Ref. 1; AAL09834 | ||||
Sequence: G → E | ||||||
Sequence conflict | 621-626 | in Ref. 1; AAL09834 | ||||
Sequence: KQPKES → RQLKEP | ||||||
Sequence conflict | 630 | in Ref. 1; AAL09834 | ||||
Sequence: L → I | ||||||
Compositional bias | 632-654 | Polar residues | ||||
Sequence: APATENVSQVVQQEPREPSINKS | ||||||
Sequence conflict | 637 | in Ref. 1; AAL09834 | ||||
Sequence: N → K | ||||||
Sequence conflict | 646 | in Ref. 1; AAL09834 | ||||
Sequence: P → A | ||||||
Sequence conflict | 649-651 | in Ref. 1; AAL09834 | ||||
Sequence: PSI → SSS | ||||||
Sequence conflict | 655-656 | in Ref. 1; AAL09834 | ||||
Sequence: DT → ER | ||||||
Sequence conflict | 659-660 | in Ref. 1; AAL09834 | ||||
Sequence: VK → GM | ||||||
Sequence conflict | 666 | in Ref. 4; AAL77653/AAN72244 | ||||
Sequence: S → R | ||||||
Sequence conflict | 675 | in Ref. 1; AAL09834 | ||||
Sequence: S → P | ||||||
Sequence conflict | 749 | in Ref. 1; AAL09834 | ||||
Sequence: N → D |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY050223 EMBL· GenBank· DDBJ | AAL09834.1 EMBL· GenBank· DDBJ | mRNA | ||
AB006706 EMBL· GenBank· DDBJ | BAB09578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED92469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY075645 EMBL· GenBank· DDBJ | AAL77653.1 EMBL· GenBank· DDBJ | mRNA | ||
BT002233 EMBL· GenBank· DDBJ | AAN72244.1 EMBL· GenBank· DDBJ | mRNA |