Q8S8E3 · PYL6_ARATH

Function

function

Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) in an ABA-independent manner but more efficiently when activated by ABA (PubMed:21658606, PubMed:23844015).
Can be activated by both --ABA and +-ABA (PubMed:23844015).
May link ABA and jasmonate signaling pathways by modifying MYC2 transcriptional activity, and regulation of JAZ6 and JAZ8 gene expression by MYC2 (PubMed:27357749).

Features

Showing features for binding site, site.

121520406080100120140160180200
TypeIDPosition(s)Description
Binding site90abscisate (UniProtKB | ChEBI)
Site119Involved in interactions with PP2Cs
Binding site120-125abscisate (UniProtKB | ChEBI)
Binding site147-153abscisate (UniProtKB | ChEBI)
Binding site174abscisate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionabscisic acid binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein phosphatase inhibitor activity
Molecular Functionsignaling receptor activity
Biological Processabscisic acid-activated signaling pathway
Biological Processjasmonic acid mediated signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Abscisic acid receptor PYL6
  • Alternative names
    • ABI1-binding protein 5
    • PYR1-like protein 6
    • Regulatory components of ABA receptor 9

Gene names

    • Name
      PYL6
    • Synonyms
      ABIP5, RCAR9
    • ORF names
      T3G21, T7M7.15
    • Ordered locus names
      At2g40330

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8S8E3
  • Secondary accessions
    • Q9S718

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cytoplasm
Nucleus
Cell membrane
Nucleus
Note: Localizes at the plasma membrane in the presence of a CAR protein (e.g. CAR1 and CAR4).

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions, but mutant seedlings exhibit increased sensitivity to abscisic acid-induced inhibition of cotyledon expansion. The inhibition effect is more severe with the combination of abscisic acid and jasmonate.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00003917411-215Abscisic acid receptor PYL6
Disulfide bond61↔190Reversible

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Monomer (PubMed:21658606).
Homodimer. Binds ABA on one subunit only (By similarity).
Interacts with HAB1, ABI1 and ABI2, and possibly with other PP2Cs (PubMed:19624469, PubMed:19874541, PubMed:19898420).
Binds to CARs protein in an ABA-independent manner, both at the plasma membrane and in the nucleus. Interacts directly with CAR1 and CAR4 (PubMed:25465408).
Interacts with MYC2 in the nucleus. Interaction with MYC2 is increased in the presence of abscisic acid (PubMed:27357749).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8S8E3ABI1 P495979EBI-2363192, EBI-782526
BINARY Q8S8E3ABI2 O047194EBI-2363192, EBI-537680
BINARY Q8S8E3ABI2 O04719-12EBI-2363192, EBI-15803514
BINARY Q8S8E3ADA2A Q9SFD53EBI-2363192, EBI-979206
BINARY Q8S8E3AIP1 Q9LNW33EBI-2363192, EBI-1573499
BINARY Q8S8E3At1g33050 Q8VYZ13EBI-2363192, EBI-25529097
BINARY Q8S8E3At1g72340 A0A1P8AVS23EBI-2363192, EBI-25528474
BINARY Q8S8E3At2g29380 Q9ZW213EBI-2363192, EBI-4441103
BINARY Q8S8E3At2g46550 Q9ZPY43EBI-2363192, EBI-25529212
BINARY Q8S8E3At4g29120 Q9SZE13EBI-2363192, EBI-25528671
BINARY Q8S8E3AXX17_At5g13230 A0A178UGU33EBI-2363192, EBI-25529113
BINARY Q8S8E3ESR1 Q9SAD43EBI-2363192, EBI-1536756
BINARY Q8S8E3G6PD3 Q8L7433EBI-2363192, EBI-2355237
BINARY Q8S8E3HAB1 Q9CAJ09EBI-2363192, EBI-2309302
BINARY Q8S8E3HAB2 Q9LNP95EBI-2363192, EBI-15803614
BINARY Q8S8E3MYB77 Q9SN123EBI-2363192, EBI-2324225
BINARY Q8S8E3NAC096 Q9LS243EBI-2363192, EBI-1238916
BINARY Q8S8E3PP2AA1 Q388453EBI-2363192, EBI-1645478
BINARY Q8S8E3PP2CA P495983EBI-2363192, EBI-1764934
BINARY Q8S8E3 Q9FLC13EBI-2363192, EBI-25529069
BINARY Q8S8E3TCP10 O822773EBI-2363192, EBI-3133327
BINARY Q8S8E3TCP13 Q9S7W53EBI-2363192, EBI-4424877
BINARY Q8S8E3TCP15 Q9C9L23EBI-2363192, EBI-4426144
BINARY Q8S8E3TCP19 Q9LT893EBI-2363192, EBI-4426178
BINARY Q8S8E3TCP3 Q9MAH83EBI-2363192, EBI-25522447
BINARY Q8S8E3TCP9 O646473EBI-2363192, EBI-9838721
BINARY Q8S8E3TIFY8 Q84MB23EBI-2363192, EBI-4426557
BINARY Q8S8E3TOE2 Q9LVG23EBI-2363192, EBI-4424568

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region54-209START-like
Motif116-120Gate loop
Motif146-148Latch loop

Domain

Upon interaction with ABA, the 'latch' and 'gate' loops change in conformation leading to a tight dimerization and the creation a surface that enables the receptor to dock into and inhibit the PP2C active site.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    23,843
  • Last updated
    2002-06-01 v1
  • Checksum
    8B9D3F7BD9E2860D
MPTSIQFQRSSTAAEAANATVRNYPHHHQKQVQKVSLTRGMADVPEHVELSHTHVVGPSQCFSVVVQDVEAPVSTVWSILSRFEHPQAYKHFVKSCHVVIGDGREVGSVREVRVVSGLPAAFSLERLEIMDDDRHVISFSVVGGDHRLMNYKSVTTVHESEEDSDGKKRTRVVESYVVDVPAGNDKEETCSFADTIVRCNLQSLAKLAENTSKFS

Sequence caution

The sequence AAD25950.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF085279
EMBL· GenBank· DDBJ
AAD25950.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AC007020
EMBL· GenBank· DDBJ
AAD25668.2
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC09815.1
EMBL· GenBank· DDBJ
Genomic DNA
BT004281
EMBL· GenBank· DDBJ
AAO42281.1
EMBL· GenBank· DDBJ
mRNA
BT005608
EMBL· GenBank· DDBJ
AAO64028.1
EMBL· GenBank· DDBJ
mRNA
AY088453
EMBL· GenBank· DDBJ
AAM65989.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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