Q8RXV3 · P2C59_ARATH
- ProteinProbable protein phosphatase 2C 59
- GeneWIN2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids311 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protein phosphatase that modulates defense response to pathogenic bacteria, conferring resistance and promoting salicylic acid (SA) accumulation.
Catalytic activity
- O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium or manganese ions per subunit.
Activity regulation
Inhibited by sodium fluoride (NaF).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 69 | Mn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 69 | Mn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 70 | Mn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 231 | Mn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 270 | Mn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | protein serine/threonine phosphatase activity | |
Biological Process | defense response to bacterium | |
Biological Process | protein dephosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable protein phosphatase 2C 59
- EC number
- Short namesAtPP2C59
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8RXV3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000367981 | 1-311 | Probable protein phosphatase 2C 59 | ||
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with the Pseudomonas syringae pv. maculicola effector HopW1-1 (via C-terminus).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-26 | Disordered | |||
Domain | 33-279 | PPM-type phosphatase | |||
Sequence similarities
Belongs to the PP2C family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)33,248
- Last updated2002-06-01 v1
- Checksum5E3098E91F116BFD
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B4X7 | A0A1P8B4X7_ARATH | WIN2 | 305 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU214909 EMBL· GenBank· DDBJ | ABW84225.1 EMBL· GenBank· DDBJ | mRNA | ||
AL031004 EMBL· GenBank· DDBJ | CAA19748.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161579 EMBL· GenBank· DDBJ | CAB79893.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE85953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | ANM66655.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY080658 EMBL· GenBank· DDBJ | AAL86334.1 EMBL· GenBank· DDBJ | mRNA | ||
AY133761 EMBL· GenBank· DDBJ | AAM91695.1 EMBL· GenBank· DDBJ | mRNA |