Q8RXS6 · INO80_ARATH

Function

function

ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (By similarity).
Binds DNA (By similarity).
As part of the INO80 complex, remodels chromatin by shifting nucleosomes (By similarity).
The INO80 complex controls ethylene-induced H2A.Z eviction dynamics (PubMed:31418686).
Positive regulator of homologous recombination, but not an essential component of homologous recombination (PubMed:15525519).
Not involved in the illegitimate repair pathway (PubMed:15525519).

Catalytic activity

Features

Showing features for binding site.

115072004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site611-618ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentIno80 complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent chromatin remodeler activity
Molecular FunctionDNA binding
Molecular Functionhistone binding
Biological Processchromatin remodeling
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chromatin-remodeling ATPase INO80
  • EC number
  • Short names
    AtINO80
  • Alternative names
    • DNA helicase-related INO80 complex homolog 1

Gene names

    • Name
      INO80
    • ORF names
      F28O9.150
    • Ordered locus names
      At3g57300

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8RXS6
  • Secondary accessions
    • Q9M2L7

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Decreased homologous recombination frequency, but unchanged sensitivity to genotoxic agents and efficiency of T-DNA integration (PubMed:15525519).
Differential expression of several genes (PubMed:31418686).
Compromised ethylene-induced H2A.Z eviction dynamics (PubMed:31418686).
The double mutant ref6-1 ino80-1 is insensitive to ethylene (ET) and exhibits reduced levels of EIN2 associated with a shift of the chromatin landscape to a repressive state at its locus (e.g. H3K27me3 and H2A.Z) (PubMed:31418686).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 80 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003758651-1507Chromatin-remodeling ATPase INO80

Proteomic databases

PTM databases

Expression

Induction

Not induced by methyl methanesulfonate (MMS) treatment.

Gene expression databases

Interaction

Subunit

Component of the INO80 chromatin-remodeling complex (By similarity).
Associates with REF6/EIN6 (PubMed:31418686).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region30-82Disordered
Compositional bias40-64Polar residues
Domain350-475DBINO
Region428-452Disordered
Domain598-769Helicase ATP-binding
Domain1210-1360Helicase C-terminal
Region1415-1507Disordered
Compositional bias1420-1442Basic and acidic residues
Compositional bias1454-1480Basic and acidic residues
Compositional bias1481-1507Polar residues

Domain

The DBINO region is involved in binding to DNA.

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

Q8RXS6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,507
  • Mass (Da)
    172,172
  • Last updated
    2009-05-26 v2
  • Checksum
    B64F7CCF96452E6B
MDPSRRPPKDSPYANLFDLEPLMKFRIPKPEDEVDYYGSSSQDESRSTQGGVVANYSNGSKSRMNASSKKRKRWTEAEDAEDDDDLYNQHVTEEHYRSMLGEHVQKFKNRSKETQGNPPHLMGFPVLKSNVGSYRGRKPGNDYHGRFYDMDNSPNFAADVTPHRRGSYHDRDITPKIAYEPSYLDIGDGVIYKIPPSYDKLVASLNLPSFSDIHVEEFYLKGTLDLRSLAELMASDKRSGVRSRNGMGEPRPQYESLQARMKALSPSNSTPNFSLKVSEAAMNSAIPEGSAGSTARTILSEGGVLQVHYVKILEKGDTYEIVKRSLPKKLKAKNDPAVIEKTERDKIRKAWINIVRRDIAKHHRIFTTFHRKLSIDAKRFADGCQREVRMKVGRSYKIPRTAPIRTRKISRDMLLFWKRYDKQMAEERKKQEKEAAEAFKREQEQRESKRQQQRLNFLIKQTELYSHFMQNKTDSNPSEALPIGDENPIDEVLPETSAAEPSEVEDPEEAELKEKVLRAAQDAVSKQKQITDAFDTEYMKLRQTSEMEGPLNDISVSGSSNIDLHNPSTMPVTSTVQTPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLPYWGGLQERTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHAILKPFMLRRVKKDVVSELTTKTEVTVHCKLSSRQQAFYQAIKNKISLAELFDSNRGQFTDKKVLNLMNIVIQLRKVCNHPELFERNEGSSYLYFGVTSNSLLPHPFGELEDVHYSGGQNPIIYKIPKLLHQEVLQNSETFCSSVGRGISRESFLKHFNIYSPEYILKSIFPSDSGVDQVVSGSGAFGFSRLMDLSPSEVGYLALCSVAERLLFSILRWERQFLDELVNSLMESKDGDLSDNNIERVKTKAVTRMLLMPSKVETNFQKRRLSTGPTRPSFEALVISHQDRFLSSIKLLHSAYTYIPKARAPPVSIHCSDRNSAYRVTEELHQPWLKRLLIGFARTSEANGPRKPNSFPHPLIQEIDSELPVVQPALQLTHRIFGSCPPMQSFDPAKLLTDSGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHRSDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEEKILHRASQKNTVQQLVMTGGHVQGDDFLGAADVVSLLMDDAEAAQLEQKFRELPLQVKDRQKKKTKRIRIDAEGDATLEELEDVDRQDNGQEPLEEPEKPKSSNKKRRAASNPKARAPQKAKEEANGEDTPQRTKRVKRQTKSINESLEPVFSASVTESNKGFDPSSSAN

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F4J277F4J277_ARATHINO801540
A0A1I9LT22A0A1I9LT22_ARATHINO801252

Sequence caution

The sequence CAB68136.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-64Polar residues
Compositional bias1420-1442Basic and acidic residues
Compositional bias1454-1480Basic and acidic residues
Compositional bias1481-1507Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL137080
EMBL· GenBank· DDBJ
CAB68136.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE79637.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
ANM65731.1
EMBL· GenBank· DDBJ
Genomic DNA
AY080695
EMBL· GenBank· DDBJ
AAL86315.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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