Q8RXF8 · MIRO1_ARATH
- ProteinMitochondrial Rho GTPase 1
- GeneMIRO1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids648 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mitochondrial GTPase required to maintain proper development, morphology and intracellular distribution of mitochondria, which in turn are essential for the progress of embryonic cell division, development of haploid male and female gametes, and pollen tube growth.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 211 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 213 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 215 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 222 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 332 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 334 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 336 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 338 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 343 | Ca2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Cellular Component | mitochondrion | |
Cellular Component | plastid | |
Molecular Function | calcium ion binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | embryo development ending in seed dormancy | |
Biological Process | mitochondrion organization | |
Biological Process | pollen tube growth |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitochondrial Rho GTPase 1
- EC number
- Short namesAtMIRO1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8RXF8
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-619 | Cytoplasmic | |||
Transmembrane | 620-640 | Helical | |||
Topological domain | 641-648 | Mitochondrial intermembrane | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Embryonic lethality between the apical 2-cell and the 4-terminal-cell embryo stage (PubMed:18344283, PubMed:20931334).
Impaired in pollen germination and pollen tube growth (PubMed:18344283).
Impaired in pollen germination and pollen tube growth (PubMed:18344283).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000431715 | 1-648 | Mitochondrial Rho GTPase 1 | ||
Modified residue | 14 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in roots, leaves, stems, flowers and siliques.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 15-182 | Miro 1 | |||
Domain | 198-233 | EF-hand 1 | |||
Domain | 319-354 | EF-hand 2 | |||
Domain | 427-595 | Miro 2 | |||
Sequence similarities
Belongs to the mitochondrial Rho GTPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length648
- Mass (Da)72,322
- Last updated2002-06-01 v1
- MD5 ChecksumE770B4CD444F5C79093D5C110B93CB52
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007478 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002688 EMBL· GenBank· DDBJ | AED93698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY081280 EMBL· GenBank· DDBJ | AAL91169.1 EMBL· GenBank· DDBJ | mRNA | ||
BT003352 EMBL· GenBank· DDBJ | AAO29970.1 EMBL· GenBank· DDBJ | mRNA |