Q8RXD3 · AIP2_ARATH

Function

function

E3 ubiquitin-protein ligase that acts as a negative regulator of abscisic acid (ABA) signaling. Mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ABI3.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionubiquitin-protein transferase activity
Biological Processabscisic acid-activated signaling pathway
Biological Processnegative regulation of abscisic acid-activated signaling pathway
Biological Processprotein ubiquitination
Biological Processresponse to abscisic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase AIP2
  • EC number
  • Alternative names
    • ABI3-interacting protein 2
    • RING-type E3 ubiquitin transferase AIP2

Gene names

    • Name
      AIP2
    • ORF names
      F22D1.80
    • Ordered locus names
      At5g20910

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Landsberg erecta
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8RXD3
  • Secondary accessions
    • Q9M4B6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Hypersensitivity to abscisic acid (ABA).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis230Loss of E3 ubiquitin ligase activity.
Mutagenesis231Loss of E3 ubiquitin ligase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003958441-310E3 ubiquitin-protein ligase AIP2

Post-translational modification

Auto-ubiquitinated.

Keywords

Proteomic databases

Expression

Tissue specificity

Highly expressed in leaves and at lower levels in flowers and seeds.

Gene expression databases

Interaction

Subunit

Interacts with ABI3 (via C-terminus).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8RXD3ABI3 Q015933EBI-2312425, EBI-1578892

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, coiled coil, compositional bias, region.

TypeIDPosition(s)Description
Zinc finger230-271RING-type; atypical
Coiled coil276-306
Compositional bias285-301Basic and acidic residues
Region285-310Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    34,807
  • Last updated
    2002-06-01 v1
  • Checksum
    47D3C96AF08D034E
MDASSSPSPSEESLKLELDDLQKQLNKKLRFEASVCSIHNLLRDHYSSSSPSLRKQFYIVVSRVATVLKTRYTATGFWVAGLSLFEEAERLVSDASEKKHLKSCVAQAKEQLSEVDNQPTESSQGYLFEGHLTVDREPPQPQWLVQQNLMSAFASIVGGESSNGPTENTIGETANLMQELINGLDMIIPDILDDGGPPRAPPASKEVVEKLPVIIFTEELLKKFGAEAECCICKENLVIGDKMQELPCKHTFHPPCLKPWLDEHNSCPICRHELPTDDQKYENWKEREKEAEEERKGAENAVRGGEYMYV

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict277in Ref. 1; CAB75509
Compositional bias285-301Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ251087
EMBL· GenBank· DDBJ
CAB75509.1
EMBL· GenBank· DDBJ
mRNA
DQ059130
EMBL· GenBank· DDBJ
AAY57616.1
EMBL· GenBank· DDBJ
mRNA
AF296834
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CP002688
EMBL· GenBank· DDBJ
AED92903.1
EMBL· GenBank· DDBJ
Genomic DNA
AY081329
EMBL· GenBank· DDBJ
AAL91218.1
EMBL· GenBank· DDBJ
mRNA
BT000238
EMBL· GenBank· DDBJ
AAN15557.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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