Q8RWY3 · ISW2_ARATH

Function

function

Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Constitutes the catalytic subunit of several complexes capable of forming ordered nucleosome arrays on chromatin (By similarity).
Involved in the formation of nucleosome distribution patterns (PubMed:24606212).
Involved in nuclear proliferation during megagametogenesis and cell expansion in the sporophyte (PubMed:16286646).
Required for the maintenance of the plant vegetative phase. In association with RLT1 or RLT2 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC (PubMed:22694359).
Necessary to acquire heat stress (HS) memory (PubMed:27680998).

Miscellaneous

Plants silencing CHR11 display reduced plant height and small cotyledonary embryos with limited cell expansion. Plants silencing CHR11 specifically at the onset of female gametogenesis (megagametogenesis) have defective female gametophytes arrested before the completion of the mitotic haploid nuclear divisions.

Features

Showing features for binding site.

110561002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site214-221ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionATP-dependent activity, acting on DNA
Molecular FunctionDNA binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Molecular Functionnucleosome array spacer activity
Molecular Functionnucleosome binding
Biological Processflower development
Biological Processmegagametogenesis
Biological Processpositive regulation of cellular response to heat
Biological Processregulation of timing of transition from vegetative to reproductive phase

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ISWI chromatin-remodeling complex ATPase CHR11
  • EC number
  • Alternative names
    • ISW2-like
    • Protein CHROMATIN REMODELING 11
    • Sucrose nonfermenting protein 2 homolog

Gene names

    • Name
      CHR11
    • ORF names
      F24P17.13
    • Ordered locus names
      At3g06400

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8RWY3
  • Secondary accessions
    • F4JAW0
    • F4JAW1
    • Q9SQU3

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced heat stress (HS) memory. Premature decline of expression of HSA32, HSP18.2, HSP21, HSP22 and HSP101 after HS in the double mutant plants chr11-1 and chr17-1 (PubMed:27680998).
No visible phenotype under normal growth conditions, but the double mutant plants chr11-1 and chr17-1 are very small and display early flowering and sterility (PubMed:22694359).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000743311-1056ISWI chromatin-remodeling complex ATPase CHR11

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in growing tissues such as inflorescence and flower meristems, young leaves and floral organs. Expressed in roots, rosette and cauline leaves, stems, flowers, inflorescences and siliques.

Developmental stage

In developing ovule, expressed in all cells of the young nucellus, including the functional megaspore. After the initiation of megagametogenesis, expressed in most cells of the ovule, including the integuments, the developing megagametophyte, and the funiculus. In mature ovules, strongly expressed in the cellularized megagametophyte. After double fertilization, expressed in the developing embryo and the free nuclear endosperm until seed maturity. Expressed in developing male gametophytes and mature pollen grains.

Gene expression databases

Interaction

Subunit

Interacts with RLT1 and RLT2 (PubMed:22694359).
Interacts (via C-terminus) with RLT1 (via the DDT domain), RLT2 (via the DDT domain), PTM (via the DDT domain) and DDR4 (via the DDT domain) (PubMed:23691993).
Binds to FGT1 (PubMed:27680998).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain, motif.

TypeIDPosition(s)Description
Region1-80Disordered
Compositional bias11-32Acidic residues
Coiled coil12-105
Compositional bias44-71Acidic residues
Region133-175Disordered
Domain201-366Helicase ATP-binding
Motif317-320DEAH box
Domain494-645Helicase C-terminal
Compositional bias738-754Basic and acidic residues
Region738-774Disordered
Region814-833Disordered
Domain840-892SANT 1
Domain941-1002SANT 2
Compositional bias1011-1029Basic and acidic residues
Region1011-1056Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8RWY3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,056
  • Mass (Da)
    122,558
  • Last updated
    2015-12-09 v4
  • Checksum
    28770AB52EBE9936
MARNSNSDEAFSSEEEEERVKDNEEEDEEELEAVARSSGSDDDEVAAADESPVSDGEAAPVEDDYEDEEDEEKAEISKREKARLKEMQKLKKQKIQEMLESQNASIDADMNNKGKGRLKYLLQQTELFAHFAKSDGSSSQKKAKGRGRHASKITEEEEDEEYLKEEEDGLTGSGNTRLLTQPSCIQGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFLGNPEERRHIREDLLVAGKFDICVTSFEMAIKEKTALRRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLEAVNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGDHLITNAGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYLYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLGINLATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTESAIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQMVRYGAEMVFSSKDSTITDEDIDRIIAKGEEATAELDAKMKKFTEDAIQFKMDDSADFYDFDDDNKDENKLDFKKIVSDNWNDPPKRERKRNYSESEYFKQTLRQGAPAKPKEPRIPRMPQLHDFQFFNIQRLTELYEKEVRYLMQTHQKNQLKDTIDVEEPEEGGDPLTTEEVEEKEGLLEEGFSTWSRRDFNTFLRACEKYGRNDIKSIASEMEGKTEEEVERYAKVFKERYKELNDYDRIIKNIERGEARISRKDEIMKAIGKKLDRYRNPWLELKIQYGQNKGKLYNEECDRFMICMIHKLGYGNWDELKAAFRTSSVFRFDWFVKSRTSQELARRCDTLIRLIEKENQEFDERERQARKEKKLAKSATPSKRPLGRQASESPSSTKKRKHLSMR

Q8RWY3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4JAV9F4JAV9_ARATHCHR111057

Sequence caution

The sequence AAF08585.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias11-32Acidic residues
Compositional bias44-71Acidic residues
Sequence conflict168in Ref. 3; AAM13851
Compositional bias738-754Basic and acidic residues
Alternative sequenceVSP_058012820in isoform 2
Compositional bias1011-1029Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC011623
EMBL· GenBank· DDBJ
AAF08585.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE74386.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE74388.1
EMBL· GenBank· DDBJ
Genomic DNA
AY091030
EMBL· GenBank· DDBJ
AAM13851.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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