Q8RWY3 · ISW2_ARATH
- ProteinISWI chromatin-remodeling complex ATPase CHR11
- GeneCHR11
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1056 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Constitutes the catalytic subunit of several complexes capable of forming ordered nucleosome arrays on chromatin (By similarity).
Involved in the formation of nucleosome distribution patterns (PubMed:24606212).
Involved in nuclear proliferation during megagametogenesis and cell expansion in the sporophyte (PubMed:16286646).
Required for the maintenance of the plant vegetative phase. In association with RLT1 or RLT2 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC (PubMed:22694359).
Necessary to acquire heat stress (HS) memory (PubMed:27680998).
Involved in the formation of nucleosome distribution patterns (PubMed:24606212).
Involved in nuclear proliferation during megagametogenesis and cell expansion in the sporophyte (PubMed:16286646).
Required for the maintenance of the plant vegetative phase. In association with RLT1 or RLT2 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC (PubMed:22694359).
Necessary to acquire heat stress (HS) memory (PubMed:27680998).
Miscellaneous
Plants silencing CHR11 display reduced plant height and small cotyledonary embryos with limited cell expansion. Plants silencing CHR11 specifically at the onset of female gametogenesis (megagametogenesis) have defective female gametophytes arrested before the completion of the mitotic haploid nuclear divisions.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent activity, acting on DNA | |
Molecular Function | DNA binding | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity | |
Molecular Function | nucleosome array spacer activity | |
Molecular Function | nucleosome binding | |
Biological Process | flower development | |
Biological Process | megagametogenesis | |
Biological Process | positive regulation of cellular response to heat | |
Biological Process | regulation of timing of transition from vegetative to reproductive phase |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameISWI chromatin-remodeling complex ATPase CHR11
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8RWY3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced heat stress (HS) memory. Premature decline of expression of HSA32, HSP18.2, HSP21, HSP22 and HSP101 after HS in the double mutant plants chr11-1 and chr17-1 (PubMed:27680998).
No visible phenotype under normal growth conditions, but the double mutant plants chr11-1 and chr17-1 are very small and display early flowering and sterility (PubMed:22694359).
No visible phenotype under normal growth conditions, but the double mutant plants chr11-1 and chr17-1 are very small and display early flowering and sterility (PubMed:22694359).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000074331 | 1-1056 | ISWI chromatin-remodeling complex ATPase CHR11 | |||
Sequence: MARNSNSDEAFSSEEEEERVKDNEEEDEEELEAVARSSGSDDDEVAAADESPVSDGEAAPVEDDYEDEEDEEKAEISKREKARLKEMQKLKKQKIQEMLESQNASIDADMNNKGKGRLKYLLQQTELFAHFAKSDGSSSQKKAKGRGRHASKITEEEEDEEYLKEEEDGLTGSGNTRLLTQPSCIQGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFLGNPEERRHIREDLLVAGKFDICVTSFEMAIKEKTALRRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLEAVNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGDHLITNAGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYLYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLGINLATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTESAIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQMVRYGAEMVFSSKDSTITDEDIDRIIAKGEEATAELDAKMKKFTEDAIQFKMDDSADFYDFDDDNKDENKLDFKKIVSDNWNDPPKRERKRNYSESEYFKQTLRQGAPAKPKEPRIPRMPQLHDFQFFNIQRLTELYEKEVRYLMQTHQKNQLKDTIDVEEPEEGGDPLTTEEVEEKEGLLEEGFSTWSRRDFNTFLRACEKYGRNDIKSIASEMEGKTEEEVERYAKVFKERYKELNDYDRIIKNIERGEARISRKDEIMKAIGKKLDRYRNPWLELKIQYGQNKGKLYNEECDRFMICMIHKLGYGNWDELKAAFRTSSVFRFDWFVKSRTSQELARRCDTLIRLIEKENQEFDERERQARKEKKLAKSATPSKRPLGRQASESPSSTKKRKHLSMR |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in growing tissues such as inflorescence and flower meristems, young leaves and floral organs. Expressed in roots, rosette and cauline leaves, stems, flowers, inflorescences and siliques.
Developmental stage
In developing ovule, expressed in all cells of the young nucellus, including the functional megaspore. After the initiation of megagametogenesis, expressed in most cells of the ovule, including the integuments, the developing megagametophyte, and the funiculus. In mature ovules, strongly expressed in the cellularized megagametophyte. After double fertilization, expressed in the developing embryo and the free nuclear endosperm until seed maturity. Expressed in developing male gametophytes and mature pollen grains.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-80 | Disordered | ||||
Sequence: MARNSNSDEAFSSEEEEERVKDNEEEDEEELEAVARSSGSDDDEVAAADESPVSDGEAAPVEDDYEDEEDEEKAEISKRE | ||||||
Compositional bias | 11-32 | Acidic residues | ||||
Sequence: FSSEEEEERVKDNEEEDEEELE | ||||||
Coiled coil | 12-105 | |||||
Sequence: SSEEEEERVKDNEEEDEEELEAVARSSGSDDDEVAAADESPVSDGEAAPVEDDYEDEEDEEKAEISKREKARLKEMQKLKKQKIQEMLESQNAS | ||||||
Compositional bias | 44-71 | Acidic residues | ||||
Sequence: EVAAADESPVSDGEAAPVEDDYEDEEDE | ||||||
Region | 133-175 | Disordered | ||||
Sequence: KSDGSSSQKKAKGRGRHASKITEEEEDEEYLKEEEDGLTGSGN | ||||||
Domain | 201-366 | Helicase ATP-binding | ||||
Sequence: IRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFLGNPEERRHIREDLLVAGKFDICVTSFEMAIKEKTALRRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPE | ||||||
Motif | 317-320 | DEAH box | ||||
Sequence: DEAH | ||||||
Domain | 494-645 | Helicase C-terminal | ||||
Sequence: LLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYLYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLGINLATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTESAIEEKVIERAYKKLALDALVIQQGRLA | ||||||
Compositional bias | 738-754 | Basic and acidic residues | ||||
Sequence: WNDPPKRERKRNYSESE | ||||||
Region | 738-774 | Disordered | ||||
Sequence: WNDPPKRERKRNYSESEYFKQTLRQGAPAKPKEPRIP | ||||||
Region | 814-833 | Disordered | ||||
Sequence: IDVEEPEEGGDPLTTEEVEE | ||||||
Domain | 840-892 | SANT 1 | ||||
Sequence: EGFSTWSRRDFNTFLRACEKYGRNDIKSIASEMEGKTEEEVERYAKVFKERYK | ||||||
Domain | 941-1002 | SANT 2 | ||||
Sequence: QNKGKLYNEECDRFMICMIHKLGYGNWDELKAAFRTSSVFRFDWFVKSRTSQELARRCDTLI | ||||||
Compositional bias | 1011-1029 | Basic and acidic residues | ||||
Sequence: EFDERERQARKEKKLAKSA | ||||||
Region | 1011-1056 | Disordered | ||||
Sequence: EFDERERQARKEKKLAKSATPSKRPLGRQASESPSSTKKRKHLSMR |
Sequence similarities
Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8RWY3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,056
- Mass (Da)122,558
- Last updated2015-12-09 v4
- Checksum28770AB52EBE9936
Q8RWY3-2
- Name2
- Differences from canonical
- 820-820: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4JAV9 | F4JAV9_ARATH | CHR11 | 1057 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-32 | Acidic residues | ||||
Sequence: FSSEEEEERVKDNEEEDEEELE | ||||||
Compositional bias | 44-71 | Acidic residues | ||||
Sequence: EVAAADESPVSDGEAAPVEDDYEDEEDE | ||||||
Sequence conflict | 168 | in Ref. 3; AAM13851 | ||||
Sequence: D → E | ||||||
Compositional bias | 738-754 | Basic and acidic residues | ||||
Sequence: WNDPPKRERKRNYSESE | ||||||
Alternative sequence | VSP_058012 | 820 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 1011-1029 | Basic and acidic residues | ||||
Sequence: EFDERERQARKEKKLAKSA |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC011623 EMBL· GenBank· DDBJ | AAF08585.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002686 EMBL· GenBank· DDBJ | AEE74386.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE74388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY091030 EMBL· GenBank· DDBJ | AAM13851.1 EMBL· GenBank· DDBJ | mRNA |