Q8RWU6 · NHX6_ARATH

Function

function

Involved in trafficking to the vacuole (PubMed:21278129).
Required for cell proliferation and cell expansion, but not for cell differentiation (PubMed:21278129).
Acts in low affinity electroneutral exchange of protons for cations such as Na+ or K+ across membranes (By similarity).
May also exchange Li+ and Cs+ with a lower affinity (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular ComponentGolgi cisterna membrane
Molecular Functionsodium:proton antiporter activity
Biological Processpotassium ion transport
Biological Processregulation of pH

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/hydrogen exchanger 6
  • Alternative names
    • Na(+)/H(+) exchanger 6 (NHE-6)

Gene names

    • Name
      NHX6
    • ORF names
      F20B17.4
    • Ordered locus names
      At1g79610

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Landsberg erecta
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8RWU6
  • Secondary accessions
    • Q8S395
    • Q9MA14

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Endosome membrane
; Multi-pass membrane protein
Golgi apparatus, Golgi stack membrane
; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-24Cytoplasmic
Transmembrane25-45Helical
Topological domain46-49Lumenal
Transmembrane50-70Helical
Topological domain71-87Cytoplasmic
Intramembrane88-108Helical
Topological domain109-126Cytoplasmic
Transmembrane127-147Helical
Topological domain148Lumenal
Transmembrane149-169Helical
Topological domain170-179Cytoplasmic
Transmembrane180-200Helical
Topological domain201-215Lumenal
Transmembrane216-236Helical
Topological domain237-271Cytoplasmic
Transmembrane272-292Helical
Topological domain293-306Lumenal
Transmembrane307-327Helical
Topological domain328-340Cytoplasmic
Transmembrane341-361Helical
Topological domain362-382Lumenal
Transmembrane383-402Helical
Topological domain403-412Cytoplasmic
Transmembrane413-433Helical
Topological domain434-535Lumenal

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype; due to redundancy with NHX5. Nhx5 and nhx6 double mutant has a slower development, is drastically smaller and is salt sensitive.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 12 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000523771-535Sodium/hydrogen exchanger 6
Glycosylation299N-linked (GlcNAc...) asparagine
Modified residue470Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in roots, leaves, stems, flowers and siliques. Detected at very low levels in roots and shoots.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region508-535Disordered
Compositional bias511-527Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8RWU6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    535
  • Mass (Da)
    59,314
  • Last updated
    2011-05-03 v3
  • Checksum
    101E72E26D409080
MSSELQISPAIHDPQGQEKQQQAAGVGILLQIMMLVLSFVLGHVLRRHKFYYLPEASASLLIGLIVGGLANISNTETSIRTWFNFHDEFFFLFLLPPIIFQSGFSLQPKPFFSNFGAIVTFSVLGTFVASMVTGLLVYLGGVMFLMYRLPFVECLMFGSLISATDPVTVLSIFQELGSDVNLYALVFGESVLNDAMAISLYRTMSLVRSHSSGQNFFMVIVRFLETFVGSMSAGVGVGFTSALLFKYAGLDVDNLQNLECCLFVLFPYFSYMLAEGLSLSGIVSILFTGIVMKHYTYSNLSANSQRFVSAFFHLISSLAETFVFIYMGFDIAMEKHSWSHLGFIFFSILFIVIARAANVFGCGYLVNLARPAHRKIPMTHQKALWYSGLRGAMAFALALQSVHDLPEGHGQTIFTATTAIVVLTVLLIGGSTGTMLEALEVVGDSHDTSLGDGFEVVNSRYMTSYDDEDTPPGSGFRTKLREFHKSAASFTELDRNYLTPFFTSNNGDYDDEGNMEQHHEERIPFTRRGNLNNRG

Q8RWU6-2

  • Name
    2
  • Note
    May be due to an intron retention.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 520-535: EERIPFTRRGNLNNRG → GNNIIL

Sequence caution

The sequence AAF68127.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict243in Ref. 2; AAF68127
Compositional bias511-527Basic and acidic residues
Alternative sequenceVSP_016703520-535in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF490590
EMBL· GenBank· DDBJ
AAM08407.1
EMBL· GenBank· DDBJ
mRNA
AC010793
EMBL· GenBank· DDBJ
AAF68127.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE36272.1
EMBL· GenBank· DDBJ
Genomic DNA
AY091100
EMBL· GenBank· DDBJ
AAM14051.1
EMBL· GenBank· DDBJ
mRNA
AY133748
EMBL· GenBank· DDBJ
AAM91682.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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