Q8RWK8 · COIL_ARATH

Function

function

Probable component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs (Probable). Required for CBs formation (PubMed:16624863).
Binds snRNAs and non-specific artificial RNA via the N-terminal part of the NOD domain and via the NLS2 region (212-282) of the IDD domain (PubMed:23320094).
The two sites are able to function independently and provide effective RNA-binding in a non-cooperative manner (PubMed:23320094).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCajal body
Molecular FunctionU1 snRNA binding
Molecular FunctionU2 snRNA binding
Biological ProcessRNA processing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Coilin
  • Alternative names
    • Atcoilin

Gene names

    • Name
      COIL
    • ORF names
      F3F19.5
    • Ordered locus names
      At1g13030

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8RWK8
  • Secondary accessions
    • Q9SAD8

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype, but loss of Cajal bodies.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis15In NOD-RK1; Decreased RNA-binding; when associated with A-16; A-20; A-23 and A-24. In NOD-RK1-2; Loss of RNA-binding; when associated with A-16; A-20; A-23; A-24; A-36; A-37; A-39 and A-40.
Mutagenesis16In NOD-RK1; Decreased RNA-binding; when associated with A-15; A-20; A-23 and A-24. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-20; A-23; A-24; A-36; A-37; A-39 and A-40.
Mutagenesis20In NOD-RK1; Decreased RNA-binding; when associated with A-15; A-16; A-23 and A-24. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-23; A-24; A-36; A-37; A-39 and A-40.
Mutagenesis23In NOD-RK1; Decreased RNA-binding; when associated with A-15; A-16; A-20 and A-24. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-20; A-24; A-36; A-37; A-39 and A-40.
Mutagenesis24In NOD-RK1; Decreased RNA-binding; when associated with A-15; A-16; A-20 and A-23. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-20; A-23; A-36; A-37; A-39 and A-40.
Mutagenesis36In NOD-RK2; No effect on RNA-binding; when associated with A-37; A39 and A-40. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-20; A-23; A-24; A-37; A-39 and A-40.
Mutagenesis37In NOD-RK2; No effect on RNA-binding; when associated with A-36; A-39 and A-40. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-20; A-23; A-24; A-36; A-39 and A-40.
Mutagenesis39In NOD-RK2; No effect on RNA-binding; when associated with A-36; A-37 and A-40. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-20; A-23; A-24; A-36; A-37 and A-40.
Mutagenesis40In NOD-RK2; No effect on RNA-binding; when associated with A-36; A-37 and A-39. In NOD-RK1-2; Loss of RNA-binding; when associated with A-15; A-16; A-20; A-23; A-24; A-36; A-37 and A-39.
Mutagenesis106In ncb-3; Smaller Cajal bodies.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004344101-608Coilin
Modified residue187Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homooligomer. Interaction with RNA results in multimerization due to structural alteration in the NOD domain.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, motif, compositional bias, domain.

TypeIDPosition(s)Description
Region134-272Disordered
Motif163-170Nuclear localization signal 1
Compositional bias175-199Basic and acidic residues
Compositional bias214-231Polar residues
Compositional bias232-249Basic and acidic residues
Motif253-260Nuclear localization signal 2
Domain410-510Tudor; atypical
Region513-585Disordered
Compositional bias564-585Polar residues

Domain

Contains a N-terminal ordered domain (NOD) (1-117), central internal disordered domain (IDD) (118-349) and a C-terminal domain (CTD) (350-608) with an atypical Tudor domain containing probably two large unstructured loops.

Sequence similarities

Belongs to the coilin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    608
  • Mass (Da)
    68,667
  • Last updated
    2002-06-01 v1
  • Checksum
    8734C1CA957CB27E
MEEEKVRVRLVFEDRRILSKYQKKQGLTRSWVVLNRKCHRTISEFSDHIFHTFSLCEACPHGLSLSMEGFVLPPFESSCVLKDKDIVCVKKKKESLLEIVGEDSDENVYNAIEVEERPQIRPGEMLLANEEFQKETGGYESESEEDELEEEAEEFVPEKKASKKRKTSSKNQSTKRKKCKLDTTEESPDERENTAVVSNVVKKKKKKKSLDVQSANNDEQNNDSTKPMTKSKRSSQQEESKEHNDLCQLSAETKKTPSRSARRKKAKRQWLREKTKLEKEELLQTQLVVAPSQKPVITIDHQATKEKHCETLENQQAEEVSDGFGDEVVPVEVRPGHIRFKPLAGTDEASLDSEPLVENVLWNGNMTKKKGQKWGTEKSGFSKRYAQDFNEDATTQPAEAETLANCPIDYEQLVAYTGSVKKGDVIAYRLIELTSSWTPEVSSFRVGKISYYDPDSKMVTLMPVQEFPIEKKTEEDDDFCMQPDTSLYKEDGSLEIEFSALLDVRSVKTSSSDSAEVAKSALPEPDQSAKKPKLSANKELQTPAKENGEVSPWEELSEALSAKKAALSQANNGWNKKGSSSGGSWSYKALRGSAMGPVMNYLRSQKEI

Sequence caution

The sequence AAD31056.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias175-199Basic and acidic residues
Compositional bias214-231Polar residues
Compositional bias232-249Basic and acidic residues
Compositional bias564-585Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC007357
EMBL· GenBank· DDBJ
AAD31056.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE28961.1
EMBL· GenBank· DDBJ
Genomic DNA
AY093028
EMBL· GenBank· DDBJ
AAM13027.1
EMBL· GenBank· DDBJ
mRNA
AY128933
EMBL· GenBank· DDBJ
AAM91333.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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