Q8RWH9 · NUP58_ARATH

Function

function

Involved in nucleocytoplasmic trafficking. May have regulatory roles in the gibberellin pathway, in auxin signaling and in light perception.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear envelope
Cellular Componentnuclear pore
Molecular Functionnuclear localization sequence binding
Molecular Functionstructural constituent of nuclear pore
Biological ProcessmRNA transport
Biological Processprotein transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear pore complex protein NUP58
  • Alternative names
    • Nucleoporin 58
    • Protein TRANSCURVATA1

Gene names

    • Name
      NUP58
    • Synonyms
      TCU1
    • ORF names
      C7A10.230
    • Ordered locus names
      At4g37130

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8RWH9
  • Secondary accessions
    • O23173

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Pleiotropic phenotype, including early flowering, increased petiole length and leaf lamina folding toward the abaxial surface in an asymmetrical manner relative to the primary vein. Hypersensitivity to 2,4-dichlorophenoxyacetic acid and paclobutrazol.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004310881-513Nuclear pore complex protein NUP58

Proteomic databases

Expression

Tissue specificity

Ubiquitous. Higherst expression in cauline leaves, lowest in roots.

Developmental stage

Detected at all developmental stages.

Gene expression databases

Interaction

Subunit

Part of the nuclear pore complex (NPC). The NPC has an eight-fold symmetrical structure comprising a central transport channel and two rings, the cytoplasmic and nuclear rings, to which eight filaments are attached. The cytoplasmic filaments have loose ends, while the nuclear filaments are joined in a distal ring, forming a nuclear basket. NPCs are highly dynamic in configuration and composition, and can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160 subcomplex and the NUP93 subcomplex, containing approximately 30 different nucleoporin proteins. Interacts with GAI, NUP62, SKP1A and SKP1B.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

Type
IDPosition(s)Description
Region28-62Disordered
Region217-239Disordered
Region356-513Disordered
Compositional bias373-505Polar residues
Repeat446-4471
Region446-4986 X 2 AA repeats of F-G
Repeat458-4592
Repeat466-4673
Repeat473-4744
Repeat486-4875
Repeat497-4986

Domain

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.

Sequence similarities

Belongs to the NUP58 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    56,542
  • Last updated
    2002-06-01 v1
  • MD5 Checksum
    394616B66F1844481C1B3FC53F6F3224
MSFFPPQQQQTPQPLFQTQQTSLFQPQQTNSIFSQSQPQQTNSIFSQSQPQQTNSIFSQPQQQQQTSLFQPQQFQQQQQQLNQQQQQQVQQQLYLFTNDKAPANYSTKWADLHPDSQKLLLQIEEKILEHRSESQRLDQCSRLYDSSVSSEGFEFDASRIVQELGGINTAMDRQKAVLHELMIVAKDMLRNAEIAVRSFMMLQPRFPHWKQGGGVVSVGSQPSQGQGTNPAPASSGQQQAVTTTVQVSDFYRGIPKKPTAFLLQTVVRFEKYLNECRQWVEELEQLLALDSDKYSRHASLLESLPKVMSNVHDFFVHVAAKVESIHQYIESMRTSYLADQRRRGECHDPFLEADRRETAKQEAAAKRVHPTLHLPASTTSTQPSTQVAGLIASSATPGGSNPPQTSVPTSNPSSGAGFSFLNTPASGPSSSLFATPSSTAPTSSLFGPSPTPTQTPLFGSSPASTFGSTQSLFGQTTPSLTMPSQFGGATPGSGASFGSMTKSSRPKSRTTRR

Sequence caution

The sequence CAB16782.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB80379.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias373-505Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z99707
EMBL· GenBank· DDBJ
CAB16782.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161590
EMBL· GenBank· DDBJ
CAB80379.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE86757.1
EMBL· GenBank· DDBJ
Genomic DNA
AY093072
EMBL· GenBank· DDBJ
AAM13071.1
EMBL· GenBank· DDBJ
mRNA
BT008879
EMBL· GenBank· DDBJ
AAP68318.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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