Q8RF47 · AROB_FUSNN
- ProteinBifunctional 3-dehydroquinate synthase/phosphatase
- GenearoB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids664 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 61-66 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 95-99 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 119-120 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 132 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 141 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 159-162 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 174 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 238 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 255 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional 3-dehydroquinate synthase/phosphatase
Including 2 domains:
- Recommended name3-dehydroquinate synthase
- EC number
- Recommended nameUnknown phosphatase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Fusobacteriota > Fusobacteriia > Fusobacteriales > Fusobacteriaceae > Fusobacterium
Accessions
- Primary accessionQ8RF47
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000140814 | 1-664 | Bifunctional 3-dehydroquinate synthase/phosphatase | ||
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-352 | 3-dehydroquinate synthase | |||
Region | 353-664 | GPPA/PPX | |||
Sequence similarities
In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
In the C-terminal section; belongs to the GppA/Ppx family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length664
- Mass (Da)76,592
- Last updated2002-06-01 v1
- ChecksumBAA617D1664402AF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE009951 EMBL· GenBank· DDBJ | AAL95067.1 EMBL· GenBank· DDBJ | Genomic DNA |