Q8RDH4 · DPPD_CALS4
- ProteinDipeptide transport ATP-binding protein DppD
- GenedppD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids326 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Part of the ABC transporter Dpp involved in dipeptide transport. Responsible for energy coupling to the transport system.
Catalytic activity
- a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H+ + phosphatea dipeptide (out)CHEBI:90799
+ CHEBI:30616 + CHEBI:15377 = a dipeptide (in)CHEBI:90799+ CHEBI:456216 + CHEBI:15378 + CHEBI:43474
Activity regulation
The C-terminal iron-sulfur cluster may stabilize the structure of the C-terminal loops and may function in the regulation of the transport process.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 44-49 | ATP (UniProtKB | ChEBI) | ||||
Sequence: ASGKST | ||||||
Binding site | 61 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 97 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 285 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 291 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 298 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 316 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | metal ion binding | |
Biological Process | peptide transport | |
Biological Process | protein transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDipeptide transport ATP-binding protein DppD
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Thermoanaerobacterales > Thermoanaerobacteraceae > Caldanaerobacter
Accessions
- Primary accessionQ8RDH4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000452197 | 1-326 | Dipeptide transport ATP-binding protein DppD | |||
Sequence: MSIIIRVEDLRAVYLVREGTIKAADGISLDILENSVTAIVGESASGKSTIIEAMTKTLPPNGRILSGRVLYKGKDLLTMREEELRKIRWKEIALVPQAAQQSLNPTMKVIEHFKDTVEAHGVRWSHSELIEKASEKLRMVRLNPEAVLNSYPLQLSGGMKQRVLIALALLLDPVVLILDEPTSALDVLTQAHIIQLLKELKKMLKITLIFVTHDIAVAAELADKVAVIYGGNLVEYNSTFQIFKNPLHPYTRGLINSIMAVNADMSKVKPIPGDPPSLLNPPSGCRFHPRCEYAMEICKKEKPKWIRLDGEAHVACHLYEEGRPLK |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-255 | ABC transporter | ||||
Sequence: IRVEDLRAVYLVREGTIKAADGISLDILENSVTAIVGESASGKSTIIEAMTKTLPPNGRILSGRVLYKGKDLLTMREEELRKIRWKEIALVPQAAQQSLNPTMKVIEHFKDTVEAHGVRWSHSELIEKASEKLRMVRLNPEAVLNSYPLQLSGGMKQRVLIALALLLDPVVLILDEPTSALDVLTQAHIIQLLKELKKMLKITLIFVTHDIAVAAELADKVAVIYGGNLVEYNSTFQIFKNPLHPYTRGLI |
Domain
Contains an N-terminal conserved nucleotide-binding domain and a C-terminal domain bound with a [4Fe-4S] cluster. The C-terminal domain forms a stable loop region and interacts with the N-terminal domain.
Sequence similarities
Belongs to the ABC transporter superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)36,361
- Last updated2002-06-01 v1
- ChecksumC3BAE78BDC12F15A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE008691 EMBL· GenBank· DDBJ | AAM23365.1 EMBL· GenBank· DDBJ | Genomic DNA |