Q8RA23 · PYRH_CALS4

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Catalytic activity

Activity regulation

Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-15ATP (UniProtKB | ChEBI)
Binding site54UMP (UniProtKB | ChEBI)
Binding site55ATP (UniProtKB | ChEBI)
Binding site59ATP (UniProtKB | ChEBI)
Binding site72UMP (UniProtKB | ChEBI)
Binding site133-140UMP (UniProtKB | ChEBI)
Binding site166ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • Ordered locus names
      TTE1407

Organism names

Accessions

  • Primary accession
    Q8RA23

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001439011-237Uridylate kinase

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    25,789
  • Last updated
    2002-06-01 v1
  • Checksum
    93F6E495E73EEB6A
MSSVVYKRVVLKISGEALAGDKEFGIDFNVVNRIADEIKEVRDLGVQIGLVVGGGNIWRGRDAVGMDRTTADHMGMLATVINALALQDALEQRGVPTRVQTAIEMRAIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTAASLRAAEIDAEVILLAKKVDGVYDKDPLKHKDAVKFKELSYLDVLNKGLGVMDSTATSLCMDNKIPIIVFDLTTYGNIKKVVMGNDIGTIVKEG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE008691
EMBL· GenBank· DDBJ
AAM24629.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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