Q8R4U9 · SGK2_RAT

  • Protein
    Serine/threonine-protein kinase Sgk2
  • Gene
    Sgk2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na+ channels: SCNN1A/ENAC, K+ channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase.

Catalytic activity

Activity regulation

Two specific sites, one in the kinase domain (Thr-193) and the other in the C-terminal regulatory region (Ser-356), need to be phosphorylated for its full activation.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site41-49ATP (UniProtKB | ChEBI)
Binding site64ATP (UniProtKB | ChEBI)
Active site159Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleoplasm
Molecular FunctionATP binding
Molecular Functionpotassium channel regulator activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase Sgk2
  • EC number
  • Alternative names
    • Serum/glucocorticoid-regulated kinase 2

Gene names

    • Name
      Sgk2

Organism names

  • Taxonomic identifier
  • Strains
    • Brown Norway
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q8R4U9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000866481-367Serine/threonine-protein kinase Sgk2
Modified residue10Phosphoserine
Modified residue193Phosphothreonine; by PDPK1
Modified residue334Phosphoserine
Modified residue356Phosphoserine
Modified residue357Phosphotyrosine

Post-translational modification

Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the proximal tubule and thick ascending limb of the loop of Henle (TALH).

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, motif.

TypeIDPosition(s)Description
Region1-28Disordered
Domain35-292Protein kinase
Motif68-77Nuclear localization signal
Domain293-367AGC-kinase C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    41,361
  • Last updated
    2006-12-12 v2
  • Checksum
    49F2231445645B50
MASSPVGVPSPQPSRANGNINLGPSANPNARPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQSHIMAERNVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQRQRLGSKEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVSKSIGCTPDTMSSSSGASSAFLGFSYAQDDDDILDS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A9X9A0A8I6A9X9_RATSgk2338
R9PXX7R9PXX7_RATSgk2361

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03025367
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AF361756
EMBL· GenBank· DDBJ
AAL91351.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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